Roles of granule size in over-granulation during high shear wet granulation

Journal of Pharmaceutical Sciences

Volumn 99, Issue 8, 2010, Pages 3322-3325

  Shi, Limin ^a   Feng, Yushi ^b   Sun, Changquan Calvin ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Granule size; High shear wet granulation; Microcrystalline cellulose; Over granulation

Indexed keywords

MICROCRYSTALLINE CELLULOSE; CELLULOSE; EXCIPIENT; POWDER; TABLET;

ARTICLE; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; HIGH SHEAR WET GRANULATION; PARTICLE SIZE; TABLET FORMULATION; TABLET POROSITY; TENSILE STRENGTH; CHEMISTRY; MEDICINAL CHEMISTRY; POWDER; TABLET;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; EXCIPIENTS; PARTICLE SIZE; POWDERS; TABLETS; TENSILE STRENGTH;

EID: 77955112280     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22118     Document Type: Article

References (17)

1. Litster JD, Ennis BJ. 2004. The Science and Engineering of Granulation Processes. 1st edition. Dordrecht, the Netherlands: Kluwer Academic Publishers.
2. Knight P. 2004. Challenges in granulation technology. Powder Technol 140:156-162.
3. Scott AC, Hounslow MJ, Instone T. 2000. Direct evidence of heterogeneity during high-shear granulation. Powder Technol 113:205-213.
4. Sun CC, Hou H, Gao P, Ma C, Medina C, Alvarez P. 2009. Development of a high drug load tablet formulation based on assessment of powder manufacturability - Moving towards quality by design. J Pharm Sci 98:239-247.
5. Faure A, Grimsey IM, Rowe RC, York P, Cliff MJ. 1999. Process control in a high shear mixer-granulator using wet mass consistency: The effect of formulation variables. J Pharm Sci 88:191-195. (Pubitemid 29084730)
6. Holm P, Schaefer T, Kristensen HG. 1985. Granulation in highspeed mixers. Part V. Power consumption and temperature changes during granulation. Powder Technol 43:212-223.
7. Kopcha M, Roland E, Bubb GE, Vadino WA. 1992. Monitoring the granulation process in a high shear mixer/granulator: An evaluation of three approaches to instrumentation. Drug Dev Ind Pharm 18:1945-1968.
8. Leuenberger H. 1982. Granulation, new techniques. Pharm Acta Helv 57:72-82.
9. Achanta AS, Adusumilli PS, James KW. 1997. Endpoint determination and its relevance to physicochemical characteristics of solid dosage forms. Drug Dev Ind Pharm 23:539-546.
10. Watano S, Numa E, Miyanami K, Osako Y. 2000. On-line monitoring of granule growth in high shear granulation by an image processing system. Chem Pharm Bull 48:1154-1159. (Pubitemid 30660273)
11. Whitaker M, Baker GR, Westrup J, Goulding PA, Rudd DR, Belchamber RM, Collins MP. 2000. Application of acoustic emission to the monitoring and end point determination of a high shear granulation process. Int J Pharm 205:79-92.
12. Sun CC. 2009. Materials Science Tetrahedron - A useful tool for pharmaceutical research and development. J Pharm Sci 98:1671-1687.
13. Sun CC. 2008. On the mechanism of reduced tabletability of granules prepared by roller compaction. Int J Pharm 347:171-172.
14. Sun CC, Himmelspach MW. 2006. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J Pharm Sci 95:200-206.
15. Badawy SIF, Gray DB, Hussain MA. 2006. A study on the effect of wet granulation on microcrystalline cellulose particle structure and performance. Pharm Res 23:634-640.
16. Johansson B, Wikberg M, Ek R, Alderborn G. 1995. Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties. Int J Pharm 117:57-73.
17. Wu SJ, Sun CC. 2007. Insensitivity of compaction properties of brittle granules to size enlargement by roller compaction. J Pharm Sci 96:1445-1450.