Predicting clonal self-renewal and extinction of hematopoietic stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 11, 2011, Pages 4370-4375

  Sieburg, Hans B ^a   Rezner, Betsy D ^a   Muller Sieburg, Christa E ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Cellular automata; Dynamical systems; Programmed aging; Systems biology

Indexed keywords

ANIMAL CELL; ARTICLE; CELL AGING; CELL ASSAY; CELL CLONE; CELL HETEROGENEITY; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CELL SYNCHRONIZATION; CELL TYPE; CLONAL VARIATION; COMPUTER SIMULATION; DAUGHTER CELL; HEMATOPOIETIC STEM CELL; MACHINE LEARNING; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; STEM CELL TRANSPLANTATION;

ANIMALS; CELL AGING; CELL PROLIFERATION; CLONE CELLS; COMPUTER SIMULATION; HEMATOPOIETIC STEM CELLS; KINETICS; MICE; MODELS, IMMUNOLOGICAL; TIME FACTORS;

EID: 79952727282     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011414108     Document Type: Article

References (48)

1. Keller G, Snodgrass R (1990) Life span of multipotential hematopoietic stem cells in vivo. J Exp Med 171:1407-1418. (Pubitemid 20167539)
2. Jordan CT, Lemischka IR (1990) Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev 4:220-232.
3. Smith LG, Weissman IL, Heimfeld S (1991) Clonal analysis of hematopoietic stem-cell differentiation in vivo. Proc Natl Acad Sci USA 88:2788-2792. (Pubitemid 21916504)
4. Osawa M, Hanada K, Hamada H, Nakauchi H (1996) Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273:242-245. (Pubitemid 26285891)
5. Müller-Sieburg CE, Cho RH, Thoman M, Adkins B, Sieburg HB (2002) Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. Blood 100: 1302-1309. (Pubitemid 34864285)
6. Matsuzaki Y, Kinjo K, Mulligan RC, Okano H (2004) Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 20:87-93. (Pubitemid 38134296)
7. McKenzie JL, Gan OI, Doedens M, Wang JC, Dick JE (2006) Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nat Immunol 7:1225-1233. (Pubitemid 44594319)
8. Zhong RK, Astle CM, Harrison DE (1996) Distinct developmental patterns of short-term and long-term functioning lymphoid and myeloid precursors defined by competitive limiting dilution analysis in vivo. J Immunol 157:138-145. (Pubitemid 26190540)
9. Morrison SJ, Weissman IL (1994) The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1: 661-673. (Pubitemid 124000730)
10. Sieburg HB, et al. (2006) The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood 107:2311-2316. (Pubitemid 43345549)
11. Lemischka IR, Raulet DH, Mulligan RC (1986) Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 45:917-927. (Pubitemid 16083695)
12. Faubert A, et al. (2008) Complementary and independent function for Hoxb4 and Bmi1 in HSC activity. Cold Spring Harbor Symp Quant Biol 73:555-564.
13. Abramovich C, Humphries RK (2005) Hox regulation of normal and leukemic hematopoietic stem cells. Curr Opin Hematol 12:210-216. (Pubitemid 40676828)
14. Song Z, et al. (2010) Alterations of the systemic environment are the primary cause of impaired B- and T-lymphopoiesis in telomere dysfunctional mice. Blood 115: 1481-1489.
15. Fleming HE, et al. (2008) Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2:274-283. (Pubitemid 351298592)
16. Zhang J, et al. (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425:836-841. (Pubitemid 37351467)
17. Wilson A, et al. (2008) Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135:1118-1129.
18. Storb R, Prentice RL, Thomas ED (1977) Marrow transplantation for treatment of aplastic anemia. An analysis of factors associated with graft rejection. N Engl J Med 296:61-66. (Pubitemid 8017136)
19. Koller MR, Manchel I, Brott DA, Palsson Bø (1996) Donor-to-donor variability in the expansion potential of human bone marrow cells is reduced by accessory cells but not by soluble growth factors. Exp Hematol 24:1484-1493. (Pubitemid 26418554)
20. Hills M, Lücke K, Chavez EA, Eaves CJ, Lansdorp PM (2009) Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA). Blood 113:5765-5775.
21. Baerlocher GM, et al. (2009) Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: The role of chronic graft-versus-host disease and female donor sex. Blood 114:219-222.
22. Awaya N, et al. (2002) Telomere shortening in hematopoietic stem cell transplantation: A potential mechanism for late graft failure? Biol Blood Marrow Transplant 8:597-600.
23. Dominietto A, et al. (2002) Transplant-related mortality and long-term graft function are significantly influenced by cell dose in patients undergoing allogeneic marrow transplantation. Blood 100:3930-3934. (Pubitemid 35396857)
24. Zubair A, et al. (2003) Early neutrophil engraftment following autologous BMT provides a functional predictor of long-term hematopoietic reconstitution. Transfusion 43:614-621. (Pubitemid 36506358)
25. Keil F, et al. (2003) Rapid establishment of long-term culture-initiating cells of donor origin after nonmyeloablative allogeneic hematopoietic stem-cell transplantation, and significant prognostic impact of donor T-cell chimerism on stable engraftment and progression-free survival. Transplantation 76:230-236. (Pubitemid 36877142)
26. Cartier N, et al. (2009) Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 326:818-823.
27. Muller-Sieburg CE, Cho RH, Karlsson L, Huang JF, Sieburg HB (2004) Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood 103:4111-4118. (Pubitemid 38685351)
28. Cho RH, Sieburg HB, Muller-Sieburg CE (2008) A new mechanism for the aging of hematopoietic stem cells: Aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 111:5553-5561.
29. Kondo M, Weissman IL, Akashi K (1997) Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91:661-672. (Pubitemid 27513657)
30. Ploemacher RE, van der Sluijs JP, Voerman JS, Brons NH (1989) An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 74:2755-2763. (Pubitemid 20007803)
31. Cho RH, Müller-Sieburg CE (2000) High frequency of long-term culture-initiating cells retain in vivo repopulation and self-renewal capacity. Exp Hematol 28:1080-1086.
32. Gisiger T (2001) Scale invariance in biology: Coincidence or footprint of a universal mechanism? Biol Rev Camb Philos Soc 76:161-209.
33. Viswanathan S, Zandstra PW (2003) Towards predictive models of stem cell fate. Cytotechnology 41:75-92. (Pubitemid 37045948)
34. Tran L, Duckstein L (2002) Comparison of fuzzy numbers using a fuzzy distance measure. Fuzzy Sets Syst 130:331-341. (Pubitemid 34862877)
35. Kaelbling L, Littman M, Moore A (1996) Reinforcement learning: A survey. J Artif Intell Res 4:237-285. (Pubitemid 126646155)
36. Kirkland MA (2004) A phase space model of hemopoiesis and the concept of stem cell renewal. Exp Hematol 32:511-519.
37. Abkowitz JL, Golinelli D, Harrison DE, Guttorp P (2000) In vivo kinetics of murine hemopoietic stem cells. Blood 96:3399-3405.
38. Roeder I, Loeffler M (2002) A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity. Exp Hematol 30:853-861. (Pubitemid 34851245)
39. Sieburg H, Clay O (1991) The cellular device machine development system for modeling biology on the computer. Complex Syst 5:575-601.
40. Blagosklonny MV (2007) Paradoxes of aging. Cell Cycle 6:2997-3003.
41. Rinkevich B, Lauzon RJ, Brown BW, Weissman IL (1992) Evidence for a programmed life span in a colonial protochordate. Proc Natl Acad Sci USA 89:3546-3550.
42. Ogawa M (1993) Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844-2853.
43. Gavrilov LA, Gavrilova NS (2003) The quest for a general theory of aging and longevity. Sci SAGE KE 2003:RE5.
44. Juckett DA, Rosenberg B (1993) Comparison of the Gompertz and Weibull functions as descriptors for human mortality distributions and their intersections. Mech Ageing Dev 69:1-31.
45. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676. (Pubitemid 44233629)
46. Rosendaal M, Hodgson GS, Bradley TR (1976) Haemopoietic stem cells are organised for use on the basis of their generation-age. Nature 264:68-69.
47. Iscove NN, Nawa K (1997) Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion. Curr Biol 7:805-808. (Pubitemid 27441837)
48. Harrison DE, Stone M, Astle CM (1990) Effects of transplantation on the primitive immunohematopoietic stem cell. J Exp Med 172:431-437. (Pubitemid 20248384)