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Volumn 18, Issue 4, 2011, Pages 545-

LRRK2 as a therapeutic target in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; ALPHA SYNUCLEIN; GUANOSINE TRIPHOSPHATASE; INDIRUBIN 3' MONOAMINEE; LEUCINE RICH REPEAT KINASE 1; LEUCINE RICH REPEAT KINASE 2; MYELIN BASIC PROTEIN; PARKIN; PINK1 PROTEIN; PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 79952714278     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2010.03305.x     Document Type: Editorial
Times cited : (8)

References (18)
  • 1
    • 79951666248 scopus 로고    scopus 로고
    • New LRRK2 variants identified in Parkinson's disease
    • Tan EK, Schapira AH. New LRRK2 variants identified in Parkinson's disease. Eur J Neurol 2011; 18: 369-370.
    • (2011) Eur J Neurol , vol.18 , pp. 369-370
    • Tan, E.K.1    Schapira, A.H.2
  • 2
    • 33748619215 scopus 로고    scopus 로고
    • The importance of LRRK2 mutations in Parkinson disease
    • Schapira AH. The importance of LRRK2 mutations in Parkinson disease. Arch Neurol 2006; 63: 1225-1228.
    • (2006) Arch Neurol , vol.63 , pp. 1225-1228
    • Schapira, A.H.1
  • 3
    • 78649610022 scopus 로고    scopus 로고
    • Genetic analysis of LRRK2 functional domains in Brazilian patients with Parkinson's disease
    • Abdalla-Carvalho CB, Santos-Rebouças CB, Guimarães BC, et al. Genetic analysis of LRRK2 functional domains in Brazilian patients with Parkinson's disease. Eur J Neurol 2010; 17: 1479-1481.
    • (2010) Eur J Neurol , vol.17 , pp. 1479-1481
    • Abdalla-Carvalho, C.B.1    Santos-Rebouças, C.B.2    Guimarães, B.C.3
  • 4
    • 34447289622 scopus 로고    scopus 로고
    • Pathogenic mutations in Parkinson disease
    • Tan EK, Skipper LM. Pathogenic mutations in Parkinson disease. Hum Mutat 2007; 28: 641-653.
    • (2007) Hum Mutat , vol.28 , pp. 641-653
    • Tan, E.K.1    Skipper, L.M.2
  • 5
    • 33846358949 scopus 로고    scopus 로고
    • The lrrk2 gly2385arg variant is associated with parkinson's disease: genetic and functional evidence
    • Tan EK, Zhao Y, Skipper L, et al. The lrrk2 gly2385arg variant is associated with parkinson's disease: genetic and functional evidence. Hum Genet 2007; 120: 857-863.
    • (2007) Hum Genet , vol.120 , pp. 857-863
    • Tan, E.K.1    Zhao, Y.2    Skipper, L.3
  • 6
    • 28044460070 scopus 로고    scopus 로고
    • Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    • West AB, Moore DJ, Biskup S, et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 2005; 102: 16842-16847.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16842-16847
    • West, A.B.1    Moore, D.J.2    Biskup, S.3
  • 8
    • 48249145829 scopus 로고    scopus 로고
    • Molecular biology changes associated with LRRK2 mutations in Parkinson's disease
    • Lu YW, Tan EK. Molecular biology changes associated with LRRK2 mutations in Parkinson's disease. J Neurosci Res 2008; 86: 1895-1901.
    • (2008) J Neurosci Res , vol.86 , pp. 1895-1901
    • Lu, Y.W.1    Tan, E.K.2
  • 9
    • 77956441086 scopus 로고    scopus 로고
    • Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
    • Lee BD, Shin JH, VanKampen J, et al. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med 2010; 16: 998-1000.
    • (2010) Nat Med , vol.16 , pp. 998-1000
    • Lee, B.D.1    Shin, J.H.2    VanKampen, J.3
  • 10
    • 67649813448 scopus 로고    scopus 로고
    • Mutant lrrk2 (r1441g) bac transgenic mice recapitulate cardinal features of parkinson's disease
    • Li Y, Liu W, Oo TF, et al. Mutant lrrk2 (r1441g) bac transgenic mice recapitulate cardinal features of parkinson's disease. Nat Neurosci 2009; 12: 826-828.
    • (2009) Nat Neurosci , vol.12 , pp. 826-828
    • Li, Y.1    Liu, W.2    Oo, T.F.3
  • 11
    • 70349103837 scopus 로고    scopus 로고
    • Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila
    • Ng CH, Mok SZ, Koh C, et al. Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J Neurosci 2009; 29: 11257-11262.
    • (2009) J Neurosci , vol.29 , pp. 11257-11262
    • Ng, C.H.1    Mok, S.Z.2    Koh, C.3
  • 12
    • 77954862456 scopus 로고    scopus 로고
    • Molecular and clinical prodrome of Parkinson disease: implications for treatment
    • Schapira AH, Tolosa E. Molecular and clinical prodrome of Parkinson disease: implications for treatment. Nat Rev Neurol. 2010; 6: 309-317.
    • (2010) Nat Rev Neurol. , vol.6 , pp. 309-317
    • Schapira, A.H.1    Tolosa, E.2
  • 13
    • 37049004489 scopus 로고    scopus 로고
    • Mitochondria in the aetiology and pathogenesis of Parkinson's disease
    • Schapira AH. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol. 2008; 7: 97-109.
    • (2008) Lancet Neurol. , vol.7 , pp. 97-109
    • Schapira, A.H.1
  • 14
    • 78649463381 scopus 로고    scopus 로고
    • Mitofusin-1 and Mitofusin-2 are ubiquitinated in a PINK1/parkin dependent manner upon induction of mitophagy
    • Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin-1 and Mitofusin-2 are ubiquitinated in a PINK1/parkin dependent manner upon induction of mitophagy. Hum Mol Genet 2010; 19: 4861-4870.
    • (2010) Hum Mol Genet , vol.19 , pp. 4861-4870
    • Gegg, M.E.1    Cooper, J.M.2    Chau, K.Y.3    Rojo, M.4    Schapira, A.H.5    Taanman, J.W.6
  • 15
    • 67649399288 scopus 로고    scopus 로고
    • Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
    • Dagda RK, Cherra SJ III, Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem. 2009; 284: 13843-13855.
    • (2009) J Biol Chem. , vol.284 , pp. 13843-13855
    • Dagda, R.K.1    Cherra III, S.J.2    Kulich, S.M.3    Tandon, A.4    Park, D.5    Chu, C.T.6
  • 16
    • 76949092128 scopus 로고    scopus 로고
    • The PINK1/Parkin pathway: a mitochondrial quality control system?
    • Whitworth AJ, Pallanck LJ. The PINK1/Parkin pathway: a mitochondrial quality control system? J Bioenerg Biomembr 2009; 41: 499-503.
    • (2009) J Bioenerg Biomembr , vol.41 , pp. 499-503
    • Whitworth, A.J.1    Pallanck, L.J.2
  • 17
    • 40349101849 scopus 로고    scopus 로고
    • Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
    • Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc Natl Acad Sci U S A 2008; 105: 1499-1504.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1499-1504
    • Deng, J.1    Lewis, P.A.2    Greggio, E.3    Sluch, E.4    Beilina, A.5    Cookson, M.R.6
  • 18
    • 77952409692 scopus 로고    scopus 로고
    • Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect
    • Sheng D, Qu D, Kwok KH, et al. Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect. PLoS Genet. 2010; 6: e1000914.
    • (2010) PLoS Genet. , vol.6
    • Sheng, D.1    Qu, D.2    Kwok, K.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.