Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: Evidence for the inhibition of angiotensin converting enzyme

Journal of Ethnopharmacology

Volumn 134, Issue 2, 2011, Pages 363-372

  Gasparotto Jr , Arquimedes ^a,b   Gasparotto, Francielly Mourão ^a   Lourenço, Emerson Luiz Botelho ^a,b   Crestani, Sandra ^b   Stefanello, Maria Elida Alves ^b   Salvador, Marcos José ^c   Da Silva Santos, José Eduardo ^d   Marques, Maria Consuelo Andrade ^b   Kassuya, Cândida Aparecida Leite ^b,e  

^a UNIVERSIDADE PARANAENSE   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^e UNIVERSIDADE FEDERAL DA GRANDE DOURADOS   (Brazil)

Author keywords

ACE inhibitors; Flavonol; Hypertension; Tropaeolaceae; Tropaeolum majus

Indexed keywords

ALCOHOL; ANGIOTENSIN I; ANGIOTENSIN II; ANTIHYPERTENSIVE AGENT; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; ISOQUERCITRIN; KAEMPFEROL; PLANT EXTRACT; TROPAEOLUM MAJUS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FLUOROMETRY; HEART RATE; HYPERTENSION; IN VIVO STUDY; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PLANT LEAF; RAT; SINGLE DRUG DOSE; SPONTANEOUSLY HYPERTENSIVE RAT; TROPAEOLACEAE; TROPAEOLUM MAJUS; WISTAR KYOTO RAT; WISTAR RAT;

ANGIOTENSIN I; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION; MALE; PEPTIDYL-DIPEPTIDASE A; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; QUERCETIN; RATS; RATS, INBRED SHR; RATS, WISTAR; TROPAEOLUM;

RATTUS; TROPAEOLACEAE; TROPAEOLUM MAJUS;

EID: 79952705244     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.12.026     Document Type: Article

References (51)

1. Addison, S., Stas, S., Hayden, M.R., Sowers, J.R., 2008. Insulin resistance and blood pressure. Current Hypertension Reports 10, 319-325.
2. Barbosa-Filho, J.M., Martins, V.K.M., Rabelo, L.A., Moura, M.D., Silva, M.S., Cunha, E.V.L., Souza, M.F.V., Almeida, R.N., Medeiros, I.A., 2006. Natural products inhibitors of the angiotensin converting enzyme (ACE): a review between 1980-2000. Revista Brasileira de Farmacognosia 16, 421-446.
3. Chang, Q., Zuo, Z., Chow, M.S., Ho, W.K., 2005. Difference in absorption of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats. European Journal of Pharmaceutics and Biopharmaceutics 59, 549-555. (Pubitemid 40347294)
4. Chen, C.H., Lin, J.Y., Lin, C.N., Hsu, S.Y., 1992. Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum. Journal of Natural Products 55, 691-695.
5. De Medeiros, J.M., Macedo, M., Contancia, J.P., Nguyen, C., Cunningham, G., Miles, D.H., 2000. Antithrombin activity of medicinal plants of the Azores. Journal of Ethnopharmacology 72, 157-165.
6. Emura, K., Yokomizo, A., Toyoshi, T., Moriwaki, M., 2007. Effect of enzymatically modified isoquercitrin in spontaneously hypertensive rats. Journal of Nutritional Science and Vitaminology 53, 68-74. (Pubitemid 46623921)
7. Enkhmaa, B., Shiwaku, K., Katsube, T., Kitajima, K., Anuurad, E., Yamasaki, M., Yamane, Y., 2005. Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. Journal of Nutrition 135, 729-734. (Pubitemid 40464095)
8. Ferreira, R.B.G., Vieira, M.C., Zárete, N.A.H., 2004. Análise de crescimento de Tropaeolum majus 'jewel' em função de espaçamentos entre plantas. Revista Brasileira de Plantas Medicinais 7, 57-66.
9. Ferro, D., 2006. Fitoterapia: conceitos clínicos. Atheneu, São Paulo.
10. Gallagher, M., Perkovic, V., Chalmers, J., 2006. Diuretics: a modern day treatment option? Nephrology 11, 419-427.
11. Gaskell, S.J., 1997. Electrospray: principles and practice. Journal of Mass Spectrometry 32, 677-688. (Pubitemid 27301433)
12. Gasparotto Junior, A., Boffo, M.A., Lourenco, E.L., Stefanello, M.E., Kassuya, C.A., Marques, M.C., 2009. Natriuretic and diuretic effects of Tropaeolum majus (Tropaeolaceae) in rats. Journal of Ethnopharmacology 122, 517-522.
13. Gasparotto Junior, A., Gasparotto, F.M., Boffo, M.A., Lourenco, E.L., Stefanello, M.E., Silva-Santos, J.E., Marques, M.C., Kassuya, C.A., in press. Diuretic and potassium-sparing effect of isoquercitrin - an active flavonoid of Tropaeolum majus L. Journal of Ethnopharmacology. doi:10.1016/j.jep.2010.12.009.
14. Griffiths, D.W., Deighton, N., Birch, A.N., Patrian, B., Baur, R., Stadler, E., 2001. Identification of glucosinolates on the leaf surface of plants from the Cruciferae and other closely related species. Phytochemistry 57, 693-700. (Pubitemid 32568733)
15. Han, G.Q., Pan, J.X., Li, C.L., Tu, F., 1991. The screening of Chinese traditional drugs by biological assay and the isolation of some active components. International Journal of Chinese Medicine 16, 1-17.
16. Israili, Z.H., Hall, W.D., 1992. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology. Annals of Internal Medicine 117, 234-242.
17. Jadhav, R.B., Bhatnagar, S.P., Surana, S.J., 2010. Diuretic activity of squamate mistletoe, Viscum angulatum. Pharmaceutical Biology 48, 417-421.
18. Khosla, N., Kalaitzidis, R., Bakris, G.L., 2009. The kidney, hypertension, and remaining challenges. Medical Clinics of North America 93, 697-715.
19. Kim, B.H., Lee, I.J., Lee, H.Y., Hwang, B.Y., Han, S.B., Kim, Y., 2007. Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages. Nitric Oxide 17, 134-142. (Pubitemid 47513847)
20. Kjaer, A., Madsen, J.O., Maeda, Y., 1978. Seed volatiles within the family Tropaeolaceae. Phytochemistry 17, 1285-1287.
21. Kwon, E.K., Lee, D.Y., Lee, H., Kim, D.O., Baek, N.I., Kim, Y.E., Kim, H.Y., 2010. Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme. Journal of Agricultural and Food Chemistry 58, 882-886.
22. Lacaille, D., Franck, U., Wagner, H., 2001. Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. Phytomedicine 8, 47-52. (Pubitemid 32242092)
23. Li, J., Wang, Z.W., Zhang, L., Liu, X., Chen, X.H., Bi, K.S., 2008. HPLC analysis and pharmacokinetic study of quercitrin and isoquercitrin in rat plasma after administration of Hypericum japonicum thunb. extract. Biomedical Chromatography 22, 374-378. (Pubitemid 351577700)
24. Li, J.S., Sharifi, A.M., Schiffrin, E.L., 1997. Effect of AT1 angiotensin-receptor blockade on structure and function of small arteries in SHR. Journal of Cardiovascular Pharmacology 30, 75-83. (Pubitemid 27527377)
25. Lorenzi, H., Matos, F.J.A., 2002. Plantas medicinais no Brasil: nativas e exóticas. Instituto Plantarum, São Paulo.
26. Lykkesfeldt, J., Moller, B.L., 1993. Synthesis of benzylglucosinolate in Tropaeolum majus L. (isothiocyanates as potent enzyme inhibitors). Plant Physiology 102, 609-613.
27. Mietkiewska, E., Giblin, E.M., Wang, S., Barton, D.L., Dirpaul, J., Brost, J.M., Katavic, V., Taylor, D.C., 2004. Seed-specific heterologous expression of a nasturtium FAE gene in Arabidopsis results in a dramatic increase in the proportion of erucic acid. Plant Physiology 136, 2665-2675. (Pubitemid 41071306)
28. Motoyama, K., Koyama, H., Moriwaki, M., Emura, K., Okuyama, S., Sato, E., Inoue, M., Shioi, A., Nishizawa, Y., 2009. Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice. Nutrition 25, 421-427.
29. Nyman, U., Joshi, P., Madsen, L.B., Pedersen, T.B., Pinstrup, M., Rajasekharan, S., George, V., Pushpangadan, P., 1998. Ethnomedical information and in vitro screening for angiotensin-converting enzyme inhibition of plants utilized as traditional medicines in Gujarat, Rajasthan and Kerala (India). Journal of Ethnopharmacology 60, 247-263. (Pubitemid 28203813)
30. Opie, L.H., 1996. ACE inhibitors in pregnancy - how to avoid the sting in the tail. South African Medical Journal 86, 326-327. (Pubitemid 26161362)
31. Park, P.J., Je, J.Y., Kim, S.K., 2003. Angiotensin I converting enzyme (ACE) inhibitory activity of hetero-chitooligosaccharides prepared from partially different deacetylated chitosans. Journal of Agricultural and Food Chemistry 51, 4930-4934.
32. Pechanova, O., Rezzani, R., Babal, P., Bernatova, I., Andriantsitohaina, R., 2006. Beneficial effects of Provinols: cardiovascular system and kidney. Physiological Research 55 (Suppl. 1), S17-S30.
33. Pfeffer, M.A., Frohlich, E.D., 2006. Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation. AJP-Heart and Circulatory Physiology 291, 2021-2025.
34. Pierdomenico, S.D., Bucci, A., Lapenna, D., Cuccurullo, F., Mezzetti, A., 2002. Heart rate in hypertensive patients treated with ACE inhibitors and long-acting dihydropyridine calcium antagonists. Journal of Cardiovascular Pharmacology 40, 288-295. (Pubitemid 34793166)
35. Roesler, R., Catharino, R.R., Malta, L.G.N., Pastore, E.M.G., 2008. Antioxidant activity of Caryocar brasiliense (pequi) and characterisation of components by electrospray ionization mass spectrometry. Food Chemistry 110, 711-717.
36. Sakamoto, T., Chen, C., Lokhandwala, F., 1994. Contribution by bradykinin to the natriuretic response to the angiotensin converting enzyme inhibitor ramiprilat in spontaneously hypertensive rats. Naunyn-Schumiedeberg's Archives of Pharmacology 350, 84-89. (Pubitemid 24214253)
37. Santos, R.A., Krieger, E.M., Greene, L.J., 1985. An improved fluorometric assay of rat serum and plasma converting enzyme. Hypertension 7, 244-252. (Pubitemid 15093650)
38. Sarikonda, V.K., Watson, R.E., Opara, O.C., DiPette, D.J., 2009. Experimental animal models of hypertension. Journal of the American Society of Hypertension 3, 158-165.
39. Schramm, D.D., German, J.B., 1998. Potential effects of flavonoids on the etiology of vascular disease. The Journal of Nutritional Biochemistry 9, 560-566. (Pubitemid 28454635)
40. Silva, C.G., Raulino, R.J., Cerqueira, D.M., Mannarino, S.C., Pereira, M.D., Panek, A.D., Silva, J.F., Menezes, F.S., Eleutherio, E.C., 2009. In vitro and in vivo determination of antioxidant activity and mode of action of isoquercitrin and Hyptis fasciculata. Phytomedicine 16, 761-767.
41. Somanadhan, B., Varughese, G., Palpu, P., Sreedharan, R., Gudiksen, L., Smitt, U.W., Nyman, U., 1999. An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants. Journal of Ethnopharmacology 65, 103-112. (Pubitemid 29267956)
42. Strittmatter, S.M., Snyder, S.H., 1986. Characterization of angiotensin converting enzyme by [3H] captopril binding. Molecular Pharmacology 29, 142-148. (Pubitemid 16165847)
43. Vitor, R.F., Mota-Filipe, H., Teixeira, G., Borges, C., Rodrigues, A.I., Teixeira, A., Paulo, A., 2004. Flavonoids of an extract of Pterospartum tridentatum showing endothelial protection against oxidative injury. Journal of Ethnopharmacology 93, 363-370. (Pubitemid 38962430)
44. Wagner, H., Elbl, G., 1992. ACE-inhibitory procyanidins from Lespedeza capitata. Planta Medica 58, 297.
45. Wielanek, M., Urbanek, H., 2006. Enhanced glucotropaeolin production in hairy root cultures of Tropaeolum majus L. by combining elicitation and precursor feeding. Plant Cell, Tissue and Organ Culture 86, 177-186. (Pubitemid 44214443)
46. Williams, B., Poulter, N.R., Brown, M.J., Davis, M., McInnes, G.T., Potter, J.F., Sever, P.S., Thom, S.M., 2004. British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. BMJ 328, 634-640. (Pubitemid 38340037)
47. Wright, C.I., Van-Buren, L., Kroner, C.I., Koning, M.M., 2007. Herbal medicines as diuretics: a review of the scientific evidence. Journal of Ethnopharmacology 114, 1-31. (Pubitemid 47454556)
48. Wu, J., Muir, A.D., 2008. Isoflavone content and its potential contribution to the antihypertensive activity in soybean Angiotensin I convertingenzymeinhibitory peptides. Journal of Agricultural and Food Chemistry 56, 9899-9904.
49. Ye, M., Han, J., Chen, H., Zheng, J., Guo, D., 2007. Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry. Journal of The American Society for Mass Spectrometry 18, 82-91. (Pubitemid 46038166)
50. Yung, L.M., Leung, F.P., Wong, W.T., Tian, X.Y., Yung, L.H., Chen, Z.Y., Yao, X.Q., Huang, Y., 2008. Tea polyphenols benefit vascular function. Inflammopharmacology 16, 230-234.
51. Zhang, Y., Lee, E.T., Devereux, R.B., Yeh, J., Best, L.G., Fabsitz, R.R., Howard, B.V., 2006. Prehypertension, diabetes, and cardiovascular disease risk in a population-based sample: the Strong Heart Study. Hypertension 47, 410-414. (Pubitemid 43740283)