Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells

Genetics and Molecular Biology

Volumn 28, Issue 3, 2005, Pages 458-463

  da Rosa Guterres, Zaira ^a   Mantovani, Mário Sérgio ^a   da Eira, Augusto Ferreira ^b   Ribeiro, Lúcia Regina ^b   Jordão, Berenice Quinzani ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Agaricus blazei; Comet assay; Micronuclei; Mushroom extracts; V79 cells

Indexed keywords

AGARICUS BLAZEI EXTRACT; ALCOHOL; CHLOROFORM; MESYLIC ACID METHYL ESTER;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL STRAIN V 79; COMET ASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EXPOSURE; DRUG ISOLATION; FUNGAL STRAIN; GENOTOXICITY; IN VITRO STUDY; MICRONUCLEUS; MUSHROOM; MUTAGENICITY; NONHUMAN;

AGARICUS BLAZEI; ANIMALIA; BASIDIOMYCOTA; CRICETULUS GRISEUS;

EID: 30544454303     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/s1415-47572005000300022     Document Type: Article

References (29)

1. Bassaganya-Riera J, Hontecillas R and Beitz DC (2002) Colonic anti-inflammatory mechanisms of conjugated linoleic acid. Clin Nutr 21:451-459.
2. Brochman E, Stack HF and Waters MD (1992) Antimutagenicity profiles of some natural substances. Mutat Res 267:157-172.
3. Chang R (1996) Functional properties of edible mushrooms. Nutrition Rev 54:11-15.
4. De Flora S (1998) Mechanisms of inhibitors of mutagenesis and carcinogenesis, Mutat Res 402:151-158.
5. De Marini M (1998) Dietary interventions of human carcinogenesis. Mutat Res 400:457-465.
6. Delmanto RD, Lima PLA, Sugui MM, da Eira AF, Salvadori DMF, Speit G and Ribeiro LIZ (2001) Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Mutat Res 496:15-21.
7. Fenech M (2000) The in vitro micronucleus technique. Mutat Res 455:81-95.
8. Ferguson LR (1994) Antimutagens as cancer chemopreventive agents in the diet. Mutat Res 307:395-410.
9. Fujimiya Y, Susuki Y, Katakura R and Ebina T (1999) Tumor-specific cytoxicity and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete Agaricus blazei Murrill. Anticancer Res 19:113-118.
10. Guterres ZR, Mantovani MS, Eira AF, Ribeiro LR and Jordão BQ (2004) Variation of the antimutagenicity, effects of water extracts of Agaricus blazei Murrill in vitro. Toxicol in Vitro 18:301-309. Available online 13 November 2003 (doi: 10.1016/j.tiv.2003.09.003).
11. Hayatsu H, Arimoto S and Negishi T (1988) Dietary inhibitors of mutagenesis and carcinogenesis. Mutat Res 202:429-446.
12. Itoh H, Amano H and Noda H (1994) Inhibitory action of a (1-6) β-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murrill ("himematsutake") on meth a fibrosarcoma-bearing mice and its antitumor mechanism. Jap J of Pharmacol 6:265-271.
13. Kojima H, Konishi H and Kuroda Y (1992) Combined mutagenicity of methyl methanesulfonate and ethyl methanesulfonate in Chinese hamster V79 cells. Mutat Res 266:171-180.
14. Kuroda Y, Jain AK, Tezuka H and Kada T (1992) Antimutagenicity in cultured mammalian cells. Mutat Res 267:201-209.
15. Lohman PHM, Gentile JM, Gentile G and Ferguson LR (2001) Antimutagenesis/ anticarcinogenesis screening, methods and biomarkers. Mutat Res 496:1-4.
16. 1) and repair deficient (xrs 5) cells by chromosome aberration and sister chromatid exchange assays. Mutat Res 528:75-79.
17. Manoharan K and Banerjee MR (1985) β-carotene reduces sister chromatid exchange induced by chemical carcinogens in mouse mammary cells in organ culture. Cell Biol Int Rep 9:783-789.
18. Menoli RCRN, Montovani MS, Ribeiro LR, Speit G and Jordão BQ (2001) Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells. Mutat Res 496:5-13.
19. Mizuno T (1995) Bioactive biomolecules of mushrooms - Food, function and medicinal effect of mushroom fungi. Food Rev Int 11:7-21.
20. Ooi VEC and Liu F (1999) A review of pharmacological activities of mushroom polysaccharides. Int J of Med Mushrooms 1:195-206.
21. Osaki Y, Kato T, Yamamoto K and Okubo J (1994) Antimutagenic and bactericidal substances in the fruit body of a basidiomycete Agaricus blazei. Yakugaku - Zasshi 114:342-350.
22. Paniza M, Park Y and Cook M (2001) The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40:283-298.
23. Salvadori DMF, Ribeiro LR and Natarajan AT (1993)The anticlastogenicity of β-carotene evaluated in human hepatoma cells. Mutat Res 303:151-156.
24. Sasaki Y, Sakaguchi M, Yamagish T, Yamada H and Shirasu Y (1994) Bio-anticlastogenic effects of unsaturated fatty acids included in fish oil- docosahexaenoic acid, docosapentaenoic acid, and eicosapentacnoic acid- in cultured Chinese hamster cells. Mutat Res 320:9-22.
25. Speit G and Hartmann A (1999) The comet assay (Single Cell Gel Test) - A sensitive genotoxicity test for the detection of DNA damage and repair. In: Henderson DS (ed) Methods in Molecular Biology. Humana Press, Berlin, pp 203-212.
26. Wahle KWJ and Hey SD (2002) Cell signal mechanisms, conjugated linoleic acids (CLAs) and anti-tumorigenesis. Prostaglandins, Leukotrienes and Fatty Acids 67:183-186.
27. Wasser SP and Weis AL (1999) Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: Modern perspective. Critical Rev in Inmunol 19:65-96.
28. Waters MD, Brady AL, Stack HF and Brockman HE (1990) Antimutagenicity profiles for some model compounds. Mutat Res 238:57-85.
29. Yamasaki M, Ykeda A, Oji M, Tanaka Y, Hirao A, Kasai M, Iwata Y, Tachibana H and Yamada K (2003) Modulation of body fat and serum leptin levels by dietary conjugate linoleic acid in Sprague Dawley rats fed various fat-level diets. Nutrition 1:30-35.