Changes in PGRMC1, a potential progesterone receptor, in human myometrium during pregnancy and labour at term and preterm

Molecular Human Reproduction

Volumn 17, Issue 4, 2011, Pages 233-242

  Wu, Wen ^a,b   Shi, Shao Qing ^b   Huang, Han Ju ^a   Balducci, J ^b   Garfield, Robert E ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Myometrium; PGRMC1; Pregnancy; Progesterone

Indexed keywords

CHORIONIC GONADOTROPIN; COMPLEMENTARY DNA; ESTRADIOL; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1; RNA; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CESAREAN SECTION; FEMALE; HORMONE ACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYSTERECTOMY; LABOR; MYOMETRIUM; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERUS CONTRACTILITY; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE; FEMALE; HUMANS; LABOR, OBSTETRIC; MEMBRANE PROTEINS; MYOMETRIUM; OBSTETRIC LABOR, PREMATURE; PREGNANCY; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79952607152     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gaq096     Document Type: Article

References (48)

1. Anderson L, Martin W, Higgins C, Nelson SM, Norman JE. The effect of progesterone on myometrial contractility, potassium channels, and tocolytic efficacy. Reprod Sci 2009;16:1052-1061.
2. Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci USA 2004; 101:12130-12135.
3. Boroditsky RS, Reyes FI, Winter JS, Faiman C. Maternal serum estrogen and progesterone concentrations preceding normal labor. Obstet Gynecol 1978;51:686-691.
4. Buddhikot M, Falkenstein E, Wehling M, Meizel S. Recognition of a human sperm surface protein involved in the progesterone-initiated acrosome reaction by antisera against an endomembrane progesterone binding protein from porcine liver. Mol Cell Endocrinol 1999;158:187-193.
5. Cahill MA. Progesterone receptor membrane component 1: an integrative review. J Steroid Biochem Mol Biol 2007;105:16-36.
6. Carlson JC, Gruber MY, Thompson JE. A study of the interaction between progesterone and membrane lipids. Endocrinology 1983;113:190-194.
7. Condon JC, Hardy DB, Kovaric K, Mendelson CR. Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Mol Endocrinol 2006; 20:764-775.
8. Conneely OM, Lydon JP. Progesterone receptors in reproduction: functional impact of the A and B isoforms. Steroids 2000;65:571-577.
9. Crudden G, Loesel R, Craven RJ. Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors. Tumour Biol 2005;26:142-146.
10. Falkenstein E, Schmieding K, Lange A, Meyer C, Gerdes D, Welsch U, Wehling M. Localization of a putative progesterone membrane binding protein in porcine hepatocytes. Cell Mol Biol (Noisy-le-grand) 1998; 44:571-578.
11. Falkenstein E, Heck M, Gerdes D, Grube D, Christ M, Weigel M, Buddhikot M, Meizel S, Wehling M. Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+-fluxes in sperm. Endocrinology 1999;140:5999-6002.
12. Gellersen B, Fernandes MS, Brosens JJ. Non-genomic progesterone actions in female reproduction. Hum Reprod Update 2009;15:119-138.
13. Gerdes D, Wehling M, Leube B, Falkenstein E. Cloning and tissue expression of two putative steroid membrane receptors. Biol Chem 1998;379:907-911.
14. Haluska GJ, Wells TR, Hirst JJ, Brenner RM, Sadowsky DW, Novy MJ. Progesterone receptor localization and isoforms in myometrium, decidua, and fetal membranes from rhesus macaques: evidence for functional progesterone withdrawal at parturition. J Soc Gynecol Investig 2002;9:125-136.
15. Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, Osteen K, Taylor RN, Lessey BA, Giudice LC. Global gene profiling in human endometrium during the window of implantation. Endocrinology 2002; 143:2119-2138.
16. Karteris E, Zervou S, Pang Y, Dong J, Hillhouse EW, Randeva HS, Thomas P. Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. Mol Endocrinol 2006; 20:1519-1534.
17. Kostrzewska A, Laudanski T, Batra S. Effect of ovarian steroids and diethylstilbestrol on the contractile responses of the human myometrium and intramyometrial arteries. Eur J Pharmacol 1993; 233:127-134.
18. Krebs CJ, Jarvis ED, Chan J, Lydon JP, Ogawa S, Pfaff DW. A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. Proc Natl Acad Sci USA 2000;97:12816-12821.
19. Krietsch T, Fernandes MS, Kero J, Lösel R, Heyens M, Lam EW, Huhtaniemi I, Brosens JJ, Gellersen B. Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone. Mol Endocrinol 2006; 20:3146-3164.
20. Labombarda F, Gonzalez SL, Deniselle MC, Vinson GP, Schumacher M, De Nicola AF, Guennoun R. Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord. J Neurochem 2003;87:902-913.
21. Lawn JE, Cousens S, Zupan J. 4 Million neonatal deaths: when? where? why? Lancet 2005;365:891-900.
22. Losel R, Dorn-Beineke A, Falkenstein E, Wehling M, Feuring M. Porcine spermatozoa contain more than one membrane progesterone receptor. Int J Biochem Cell Biol 2004;36:1532-1541.
23. MacDonald PC, Dombroski RA, Casey ML. Recurrent secretion of progesterone in large amounts: an endocrine/metabolic disorder unique to young women? Endocr Rev 1991;12:372-401.
24. Merlino AA, Welsh TN, Tan H, Yi LJ, Cannon V, Mercer BM, Mesiano S. Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A. J Clin Endocrinol Metab 2007;92:1927-1933.
25. Mesiano S. Roles of estrogen and progesterone in human parturition. Front Horm Res 2001;27:86-104.
26. Mesiano S, Welsh TN. Steroid hormone control of myometrial contractility and parturition. Semin Cell Dev Biol 2007;18:321-331.
27. Meyer C, Schmid R, Scriba PC, Wehling M. Purification and partial sequencing of high-affinity progesterone-binding site(s) from porcine liver membranes. Eur J Biochem 1996;239:726-731.
28. Min L, Strushkevich NV, Harnastai IN, Iwamoto H, Gilep AA, Takemori H, Usanov SA, Nonaka Y, Hori H, Vinson GP et al. Molecular identification of adrenal inner zone antigen as a heme-binding protein. FEBS J 2005; 272:5832-5843.
29. Mitchell BF, Taggart MJ. Are animal models relevant to key aspects of human parturition? Am J Physiol Regul Integr Comp Physiol 2009; 297:R525-R545.
30. Nolte I, Jeckel D, Wieland FT, Sohn K. Localization and topology of ratp28:a member of a novel family of putative steroid-binding proteins. Biochim Biophys Acta 2000;1543:123-130.
31. Peluso JJ, Pappalardo A, Losel R, Wehling M. Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action. Endocrinology 2006;147:3133-3140.
32. Peluso JJ, Romak J, Liu X. Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 mutations. Endocrinology 2008a;149:534-543.
33. Peluso JJ, Liu X, Saunders MM, Claffey KP, Phoenix K. Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1. J Clin Endocrinol Metab 2008b; 93:1592-1599.
34. Peluso JJ, Liu X, Gawkowska A, Johnston-MacAnanny E. Progesterone activates a progesterone receptor membrane component 1-dependent mechanism that promotes human granulosa/luteal cell survival but not progesterone secretion. J Clin Endocrinol Metab 2009; 94:2644-1649.
35. Pieber D, Allport VC, Hills F, Johnson M, Bennett PR. Interactions between progesterone receptor isoforms in myometrial cells in human labour. Mol Hum Reprod 2001;7:875-879.
36. Raza FS, Takemori H, Tojo H, Okamoto M, Vinson GP. Identification of the rat adrenal zona fasciculata/reticularis specific protein, inner zone antigen (IZAg), as the putative membrane progesterone receptor. Eur J Biochem 2001;268:2141-2147.
37. Rohe HJ, Ahmed IS, Twist KE, Craven RJ. PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding. Pharmacol Ther 2009;121:14-19.
38. Ruddock NK, Shi SQ, Jain S, Moore G, Hankins GD, Romero R, Garfield RE. Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions. Am J Obstet Gynecol 2008;199:391 e17.
39. Runko E, Wideman C, Kaprielian Z. Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS. Mol Cell Neurosci 1999; 14:428-443.
40. Samalecos A, Gellersen B. Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms. Endocrinology 2008;149:5872-5887.
41. Soloff MS, Jeng YJ, Ilies M, Soloff SL, Izban MG, Wood TG, Panova NI, Velagaleti GV, Anderson GD. Immortalization and characterization of human myometrial cells from term-pregnant patients using a telomerase expression vector. Mol Hum Reprod 2004;10:685-695.
42. Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, Le Shay N, Nezhat CN, Kempson R, Lessey BA et al. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology 2006;147:1097-1121.
43. Thomas P. Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions. Front Neuroendocrinol 2008;29:292-312.
44. Tulchinsky D, Hobel CJ, Yeager E, Marshall JR. Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol 1972; 112:1095-1100.
45. Walsh SW, Stanczyk FZ, Novy MJ. Daily hormonal changes in the maternal, fetal, and amniotic fluid compartments before parturition in a primate species. J Clin Endocrinol Metab 1984;58:629-639.
46. Wentz MJ, Jamaluddin M, Garfield RE, Al-Hendy A. Regulation of catechol-O-methyltransferase expression in human myometrial cells. Obstet Gynecol 2006;108:1439-1447.
47. Zhu Y, Rice CD, Pang Y, Pace M, Thomas P. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Proc Natl Acad Sci USA 2003a;100:2231-2236.
48. Zhu Y, Bond J, Thomas P. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Proc Natl Acad Sci USA 2003b;100:2237-2242.