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Volumn 22, Issue 1-2, 2011, Pages 67-88

Non-testing approaches under REACH - help or hindrance? perspectives from a practitioner within industry

Author keywords

(Q)SAR; Chemical Category; QMRF; QPRF; REACH

Indexed keywords

LAWS AND LEGISLATION;

EID: 79952602472     PISSN: 1062936X     EISSN: 1029046X     Source Type: Journal    
DOI: 10.1080/1062936X.2010.528448     Document Type: Article
Times cited : (17)

References (25)
  • 1
    • 51849127476 scopus 로고    scopus 로고
    • Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94
    • European Union
    • European Union, Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC, Official Journal, L 396 (2006), pp. 1-850.
    • (2006) Official Journal, L , vol.396 , pp. 1-850
  • 2
    • 0003188912 scopus 로고
    • Council Directive 79/831/EEC of 18 September 1979 amending for the sixth time Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances
    • European Union
    • European Union, Council Directive 79/831/EEC of 18 September 1979 amending for the sixth time Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances, Official Journal L 259 (1979), pp. 10-28.
    • (1979) Official Journal L , vol.259 , pp. 10-28
  • 7
    • 33646485030 scopus 로고    scopus 로고
    • EUR 21866 EN, European Commission-Joint Research Centre, Ispra, Italy, Available at, (Accessed 7 July 2010)
    • Worth, A. Bassan, A. Gallegos, T.I. Netzeva, G. Patlewicz, M. Pavan, I. Tsakovska, and M. Vracko, The Characterisation of (Quantitative) Structure-Activity Relationships: Preliminary Guidance, EUR 21866 EN, European Commission-Joint Research Centre, Ispra, Italy, 2005. Available at: http://www.ecb.jrc.ec.europa.eu/DOCUMENTS/QSAR/QSAR_characterisation_EUR_ 21866_EN.pdf (Accessed 7 July 2010).
    • (2005) The Characterisation of (Quantitative) Structure-Activity Relationships: Preliminary Guidance
  • 10
    • 0026606514 scopus 로고
    • Predicting skin permeability
    • R.O. Potts and R.H. Guy, Predicting skin permeability, Pharm. Res. 9 (1992), pp. 663-669.
    • (1992) Pharm. Res , vol.9 , pp. 663-669
    • Potts, R.O.1    Guy, R.H.2
  • 12
    • 0025071340 scopus 로고
    • Rules for distinguishing toxicants that cause type I and type II narcosis syndromes
    • G.D Veith and S.J Broderius, Rules for distinguishing toxicants that cause type I and type II narcosis syndromes, Environ Health Perspect. 87 (1990), pp. 207-211.
    • (1990) Environ Health Perspect , vol.87 , pp. 207-211
    • Veith, G.D.1    Broderius, S.J.2
  • 14
    • 47349112107 scopus 로고    scopus 로고
    • Toxmatch - a new software tool to aid in the development and evaluation of chemically similar groups
    • G. Patlewicz, N. Jeliazkova, A. Gallegos Saliner, and A.P. Worth, Toxmatch - a new software tool to aid in the development and evaluation of chemically similar groups, SAR QSAR Environ. Res. 19 (2008), pp. 397-412.
    • (2008) SAR QSAR Environ. Res , vol.19 , pp. 397-412
    • Patlewicz, G.1    Jeliazkova, N.2    Gallegos, S.A.3    Worth, A.P.4
  • 15
    • 84987862887 scopus 로고    scopus 로고
    • Worth and G. Patlewicz, European Commission report EUR 22481 EN. European Commission-Joint Research Centre, Ispra, Italy, Available at, (Accessed 7 July 2010)
    • Worth and G. Patlewicz, A compendium of case studies that helped to shape the REACH Guidance on Chemical Categories and Read Across, European Commission report EUR 22481 EN. European Commission-Joint Research Centre, Ispra, Italy, 2007. Available at: http://www.ecb.jrc.ec.europa.eu/DOCUMENTS/QSAR/EUR_22481_EN.pdf (Accessed 7 July 2010).
    • (2007) A Compendium of Case Studies That Helped to Shape the REACH Guidance On Chemical Categories and Read Across
  • 16
    • 38849171093 scopus 로고    scopus 로고
    • A review of (Q)SAR models for skin and eye irritation and corrosion
    • A. Gallegos Saliner, G. Patlewicz, and A.P. Worth, A review of (Q)SAR models for skin and eye irritation and corrosion, QSAR & Comb Sci. 27 (2008), pp. 49-59.
    • (2008) QSAR & Comb Sci , vol.27 , pp. 49-59
    • Gallegos, S.A.1    Patlewicz, G.2    Worth, A.P.3
  • 17
    • 38849134167 scopus 로고    scopus 로고
    • A mini review of available (Q)SARs and Expert systems for skin sensitisation
    • G. Patlewicz, A.O. Aptula, D.W. Roberts, and E. Uriarte, A mini review of available (Q)SARs and Expert systems for skin sensitisation, QSAR & Comb Sci. 27 (2008), pp. 60-76.
    • (2008) QSAR & Comb Sci , vol.27 , pp. 60-76
    • Patlewicz, G.1    Aptula, A.O.2    Roberts, D.W.3    Uriarte, E.4
  • 18
    • 38849184107 scopus 로고    scopus 로고
    • Predicting toxicological and ecotoxicological endpoints
    • C.J. Leeuwen and T. Vermeire, eds., Springer
    • A.P. Worth, T.I. Netzeva, and G. Patlewicz, Predicting toxicological and ecotoxicological endpoints, in Risk Assessment of Chemicals, C.J. Leeuwen and T. Vermeire, eds., Springer, 2007, pp. 427-465.
    • (2007) Risk Assessment of Chemicals , pp. 427-465
    • Worth, A.P.1    Netzeva, T.I.2    Patlewicz, G.3
  • 20
    • 0026785215 scopus 로고
    • Classifying environmental pollutants. 1. Structure-activity relationships for prediction of aquatic toxicity
    • H.J.M. Verhaar, C.J. van Leeuwen, and J.L.M. Hermens, Classifying environmental pollutants. 1. Structure-activity relationships for prediction of aquatic toxicity, Chemosphere 25 (1992), pp. 471-491.
    • (1992) Chemosphere , vol.25 , pp. 471-491
    • Verhaar, H.J.M.1    van Leeuwen, C.J.2    Hermens, J.L.M.3
  • 21
    • 53949119408 scopus 로고
    • Quantitative structure-activity relationships
    • P. Calow, ed., Blackwell Scientific Publications, London
    • P. Donkin, Quantitative structure-activity relationships, in Handbook of Ecotoxicology vol. 2, P. Calow, ed., Blackwell Scientific Publications, London, 1994.
    • (1994) Handbook of Ecotoxicology , vol.2
    • Donkin, P.1
  • 22
    • 0019517032 scopus 로고
    • Quantitative structure-activity relationships in fish toxicity studies 1. Relationship for 50 industrial pollutants
    • H. Konemann, Quantitative structure-activity relationships in fish toxicity studies 1. Relationship for 50 industrial pollutants, Toxicology 19 (1981), pp. 209-221.
    • (1981) Toxicology , vol.19 , pp. 209-221
    • Konemann, H.1
  • 23
    • 22044433824 scopus 로고    scopus 로고
    • Assessment of the eye irritating properties of chemicals by applying alternatives to the Draize rabbit eye test: The use of QSARs and in vitro tests for the classification of eye irritation
    • I. Gerner, M. Liebsch, and H. Spielmann, Assessment of the eye irritating properties of chemicals by applying alternatives to the Draize rabbit eye test: The use of QSARs and in vitro tests for the classification of eye irritation, ATLA 33 (2005), pp. 215-237.
    • (2005) ATLA , vol.33 , pp. 215-237
    • Gerner, I.1    Liebsch, M.2    Spielmann, H.3
  • 24
    • 18344375332 scopus 로고    scopus 로고
    • The Skin Irritation Corrosion Rules Estimation Tool (SICRET)
    • J.D. Walker, I. Gerner, E. Hulzebos, and K. Schlegel, The Skin Irritation Corrosion Rules Estimation Tool (SICRET), QSAR Comb. Sci. 24 (2005), pp. 378-384.
    • (2005) QSAR Comb. Sci , vol.24 , pp. 378-384
    • Walker, J.D.1    Gerner, I.2    Hulzebos, E.3    Schlegel, K.4
  • 25
    • 33748640373 scopus 로고    scopus 로고
    • Mechanistic applicability domains for nonanimal-based prediction of toxicological end points: General principles and application to reactive toxicity
    • A.O. Aptula and D.W. Roberts, Mechanistic applicability domains for nonanimal-based prediction of toxicological end points: General principles and application to reactive toxicity, Chem. Res. Toxicol. 19 (2006), pp. 1097-1105.
    • (2006) Chem. Res. Toxicol , vol.19 , pp. 1097-1105
    • Aptula, A.O.1    Roberts, D.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.