Quantitative analysis of antiretroviral drugs in lysates of peripheral blood mononuclear cells using MALDI-triple quadrupole mass spectrometry

Analytical Chemistry

Volumn 80, Issue 13, 2008, Pages 4969-4975

  Van Kampen, Jeroen J A ^a,b   Burgers, Peter C ^a   Gruters, Rob A ^a   Osterhaus, Albert D M E ^a   De Groot, Ronald ^c   Luider, Theo M ^a   Volmer, Dietrich A ^d  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABERRATIONS; BLOOD; CHEMOTHERAPY; CLADDING (COATING); DESORPTION; DRUG DELIVERY; DRUG DOSAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IRON; MASS SPECTROMETERS; MASS SPECTROMETRY; MATRIX ALGEBRA; NEUROLOGY; OPTICAL PROPERTIES; PHOTORESISTS; PLASTIC COATINGS; PLATES (STRUCTURAL COMPONENTS); POLYMERS; PULSED LASER DEPOSITION; SPECTROMETERS; SPECTROMETRY; STEEL ANALYSIS; TARGETS;

AMERICAN CHEMICAL SOCIETY (ACS); ANTIRETROVIRAL DRUGS; CLINICAL APPLICATIONS; DIHYDROXYBENZOIC ACID (DHBA); FLUOROPOLYMER COATING; HIV PROTEASES; INFECTED PATIENTS; LOWER LIMITS OF QUANTITATION (LLOQ); LYSATES; MATRIX-ASSISTED LASER-DESORPTION/IONIZATION (MALDI); MEAN PRECISION; MEAN RELATIVE ERRORS; MEAN RELATIVE ERRORS (MRE); MEASUREMENT TIME; PERIPHERAL BLOOD MONO NUCLEAR CELLS (PBMC); PERIPHERAL BLOOD MONONUCLEAR CELL (PBMC); QUANTITATIVE ANALYSIS; SAQUINAVIR; TRIFLUORO METHYL; TRIPLE QUADRUPOLE MASS SPECTROMETER; TRIPLE QUADRUPOLE MASS SPECTROMETRY;

STAINLESS STEEL;

7 HYDROXY 4 (TRIFLUOROMETHYL)COUMARIN; ANTIRETROVIRUS AGENT; CARBAMAZEPINE; COUMARIN DERIVATIVE; FLUORINE DERIVATIVE; GENTISIC ACID; INDINAVIR; LOPINAVIR; NEVIRAPINE; POLYMER; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

ACCURACY; ANALYTICAL ERROR; ARTICLE; CELL LYSATE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HYDROPHOBICITY; MASS SPECTROMETER; MATERIAL COATING; MATRIX ASSISTED LASER DESORPTION IONIZATION TRIPLE QUADRUPOLE MASS SPECTROMETRY; MEASUREMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS;

ANTIVIRAL AGENTS; COUMARINS; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; LEUKOCYTES, MONONUCLEAR; REVERSE TRANSCRIPTASE INHIBITORS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 46849085355     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac800218a     Document Type: Article

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