Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 736, Issue 1-2, 1999, Pages 115-121

  Sparidans, Rolf W ^a,b   Veldkamp, Agnes ^b   Hoetelmans, Richard M W ^b   Beijnen, Jos H ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

Adefovir; Chloroacetaldehyde; Derivatization, LC

Indexed keywords

ADEFOVIR;

ACCURACY; ANALYTIC METHOD; ARTICLE; CALIBRATION; CONTROLLED STUDY; DERIVATIZATION; DRUG DETERMINATION; HUMAN; ION PAIR CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ASSAY;

ACETALDEHYDE; ADENINE; ANTIVIRAL AGENTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FLUORESCENT DYES; HUMANS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; PHOSPHONIC ACIDS; PRECIPITATION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; TRICHLOROACETIC ACID;

EID: 0032724503     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00447-8     Document Type: Article

References (9)

1. Nicoll A., Locarnini S. J. Gastroenterol. Hepatol. 12:1997;843.
2. Schmit J.-C., Weber B. Intervirology. 40:1997;304.
3. Shaw J.-P., Loui M.S., Krishnamurty V.V., Armilli M.N., Jones R.J., Bidgood A.M., Lee W.A., Cundy K.C. Drug Metab. Dispos. 25:1997;362.
4. Cundy K.C., Barditch-Crovo P., Walker R.E., Collier A.C., Ebeling D., Toole J., Jaffe H.S. Antimicrob. Agents Chemother. 39:1995;2401.
5. Miller M.D., Lamy P.D., Fuller M.D., Mulato A.S., Margot N.A., Cihlar T., Cherrington J.M. Mol. Pharmacol. 54:1998;291.
6. Cundy K.C. Clin. Pharmacokin. 36:1999;127.
7. Naesens L., Balzarini J., De Clerq E. Clin. Chem. 38:1992;480.
8. Russell J.W., Marrero D., Whiterock V.J., Klunk L.J., Starret J.E. J. Chromatogr. 572:1991;321.
9. Shah V.P., Midha K.K., Dighe S., McGliveray I.J., Skelly J.P., Jacobi A., Layloff T., Viswanathan C.T., Cook C.E., McDowall R.D., Pittman K.A., Spector S. J. Pharm. Sci. 81:1992;309.