Polyketide decarboxylative chain termination preceded by O-sulfonation in curacin A biosynthesis

Journal of the American Chemical Society

Volumn 131, Issue 44, 2009, Pages 16033-16035

  Gu, Liangcai ^a,d   Wang, Bo ^a   Kulkarni, Amol ^b   Gehret, Jennifer J ^a   Lloyd, Kayla R ^b   Gerwick, Lena ^c   Gerwick, William H ^c   Wipf, Peter ^b   Håkansson, Kristina ^a   Smith, Janet L ^a   Sherman, David H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC DOMAINS; CHAIN ELONGATION; CHAIN TERMINATIONS; HYDROXYL GROUPS; MARINE CYANOBACTERIUM; NATURAL PRODUCTS; POLYKETIDE SYNTHASES; POLYKETIDES; TERMINAL OLEFINS; THIOESTERASES;

BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; FLUORINE CONTAINING POLYMERS; LEAD COMPOUNDS; OLEFINS; SULFONATION;

SETTLING TANKS;

ACYL CARRIER PROTEIN; CURACIN A; POLYKETIDE; SULFOTRANSFERASE; THIOL ESTER HYDROLASE;

AMINO ACID SEQUENCE; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; SULFONATION;

ANTINEOPLASTIC AGENTS; BACTERIAL PROTEINS; CYANOBACTERIA; CYCLOPROPANES; DECARBOXYLATION; MACROLIDES; METABOLIC NETWORKS AND PATHWAYS; POLYKETIDE SYNTHASES; SULFONES; SULFOTRANSFERASES; THIAZOLES; TUBULIN MODULATORS;

EID: 70450195870     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9071578     Document Type: Article

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