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Volumn , Issue 9, 2011, Pages 1627-1631

I2-induced stereospecific synthesis of 4-piperidones through double mannich reaction and tandem cyclization

Author keywords

Cyclization; Diastereoselectivity; Iodine; Nitrogen heterocycles

Indexed keywords


EID: 79952517806     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.201001607     Document Type: Article
Times cited : (7)

References (60)
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    • During the first step of Mannich addition, the less-substituted α-carbon of the asymmetric ketones would add to the imines, which was supported by the isolation of the corresponding β-aminoketones as major byproducts, although reverse regioselectivity was found in many Mannich reactions. The main reason is probably due to steric effects.
    • During the first step of Mannich addition, the less-substituted α-carbon of the asymmetric ketones would add to the imines, which was supported by the isolation of the corresponding β-aminoketones as major byproducts, although reverse regioselectivity was found in many Mannich reactions. The main reason is probably due to steric effects.
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    • More discussions concerning the transition state and the selectivity
    • More discussions concerning the transition state and the selectivity


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.