High-shear- and-thrombin-inducible platelet adhesion and aggregation in patients undergoing percutaneous coronary intervention: Effects of unfractionated heparin versus bivalirudin

Thrombosis and Haemostasis

Volumn 105, Issue 3, 2011, Pages 496-500

  Eslam, Roza Badr ^a   Reiter, Nina ^a   Kaider, Alexandra ^a   Lang, Irene M ^a   Panzer, Simon ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bivalirudin; Heparin; High shear; Platelet function; Thrombin

Indexed keywords

HEPARIN; HIRULOG; THROMBIN;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; SHEAR STRESS; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

AGED; ANGIOPLASTY, BALLOON, CORONARY; ANTICOAGULANTS; FEMALE; HEMORRHAGE; HEPARIN; HIRUDINS; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PLATELET ADHESIVENESS; PLATELET AGGREGATION; RECOMBINANT PROTEINS; SHEAR STRENGTH; THROMBIN; THROMBOSIS;

EID: 79952511801     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-06-0384     Document Type: Article

References (33)

1. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest 1999; 103: 879-887. (Pubitemid 29152634)
2. Leger AJ, Covic L , Kuliopulos A. Protease-Activated Receptors in Cardiovascular Diseases. Circulation 2006; 114: 1070-1077. (Pubitemid 44358884)
3. Dormann D, Clemetson KJ, Kehrel BE. The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity. Blood 2000; 96: 2469-2478.
4. Soslau G, Class R, Morgan DA, et al. Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib. J Biol Chem 2001; 276: 21173-21183.
5. Adam F, Guillin MC, Jandrot-Perrus M. Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin. Eur J Biochem 2003; 270: 2959-2970. (Pubitemid 36876265)
6. Jurk K, Jahn UR, Van Aken H, et al. Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1). Thromb Haemost 2004; 91: 334-344. (Pubitemid 38240180)
7. Yano Y, Ohmori T, Hoshide S, et al. Determinants of thrombin generation, fibrinolytic activity, and endothelial dysfunction in patients on dual antiplatelet therapy: involvement of factors other than platelet aggregability in Virchow's triad. Eur Heart J 2008; 29: 1729-1738. (Pubitemid 352019807)
8. Becker RC, Moliterno DJ, Jennings LK, et al; TRA-PCI Investigators. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study. Lancet 2009; 373: 919-928.
9. Dardik R, Varon D, Eskaraev R, et al. Recombinant fragment of von Willebrand factor AR545C inhibits platelet binding to thrombin and platelet adhesion to thrombin-treated endothelial cells. Br J Haematol 2000; 109: 512-518. (Pubitemid 30415174)
10. Warkentin TE, Greinacher A, Koster A. Bivalirudin. Thromb Haemost. 2008; 99: 830-839.
11. De Luca G, Cassetti E, Verdoia M, et al. Bivalirudin as compared to unfractionated heparin among patients undergoing coronary angioplasty: A meta-analyis of randomised trials. Thromb Haemost. 2009; 102: 428-436.
12. Xiao Z, Theroux P. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor. Circulation 1998; 97: 251-256. (Pubitemid 28067310)
13. Schneider DJ, Keating F, Sobel BE. Greater inhibitory effects of bivalirudin compared with unfractionated heparin plus eptifibitide on thrombin-induced platelet activation. Coron Artery Dis 2006; 17: 471-476. (Pubitemid 44309788)
14. Keating FK, Dauerman HL, Whitaker DA, et al. Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin. Thromb Res 2006; 118: 361-369. (Pubitemid 44067197)
15. Harding SA, Din JN, Sarma J, et al. Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin. Heart 2006; 92: 1635-1638. (Pubitemid 44629174)
16. Sobel M, Fish WR, Toma N, et al. Heparin modulates integrin function in human platelets J Vasc Surg 2001; 33: 587-594.
17. Anand SX, Kim MC, Kamran M, et al. Comparison of platelet function and morphology in patients undergoing percutaneous coronary intervention receiving bivalirudin versus unfractionated heparin versus clopidogrel pretreatment and bivalirudin. Am J Cardiol 2007; 100: 417-424. (Pubitemid 47094690)
18. Reiter R, Derhaschnig U, Spiel A, et al. Regulation of protease-activated receptor 1 (PAR1) on platelets and responsiveness to thrombin receptor activating peptide (TRAP) during systemic inflammation in humans. Thromb Haemost 2003; 90: 898-903. (Pubitemid 37427860)
19. Lincoff AM, Bittl JA, Harrington RA, et al. Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. J Am Med Assoc 2003; 289: 853-863. (Pubitemid 37430344)
20. Stone GW, White HD, Ohman EM, et al. Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. Lancet 2007; 369: 907-919. (Pubitemid 46400858)
21. Stone GW, Witzenbichler B, Guagliumi G, et al. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med 2008; 358: 2218-2230. (Pubitemid 351724451)
22. White HD, Chew DP, Hoekstra JW, et al. Safety and efficacy of switching from either unfractionated heparin or enoxaparin to bivalirudin in patients with non-ST-segment elevation acute coronary syndromes managed with an invasive strategy: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. J Am Coll Cardiol 2008; 51: 1734-1741. (Pubitemid 351621989)
23. Eslam RB, Reiter N, Kaider A, et al. Regulation of PAR-1 in patients undergoing percutaneous coronary intervention: effects of unfractionated heparin and bivalirudin. Eur Heart J 2009; 30: 1831-1836.
24. Savion N, Varon D. Impact - the cone and plate(let) analyzer: testing platelet function and anti-platelet drug response. Pathophysiol Haemost Thromb 2006; 35: 83-88.
25. Shenkman B, Matetzky S, Fefer P, et al. Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests. Thromb Res 2008; 122: 336-345.
26. Gremmel T, Steiner S, Seidinger D, et al. Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation. Thromb Haemost 2009; 101: 333-339.
27. Storey RF, May JA, Heptinstall S. Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin. Thromb Res 2005; 115: 301-307.
28. Goto S, Salomon DR, Ikeda Y, et al. Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets. J Biol Chem 1995; 270: 23352-23361.
29. Goto S, Tamura N, Li M, et al. Different effects of various anti-GPIIb-IIIa agents on shear-induced platelet activation and expression of procoagulant activity. J Thromb Haemost 2003; 1: 2022-2030.
30. Panzer S, Eichelberger B, Koren D, et al. Monitoring survival and function of transfused platelets in Bernard-Soulier syndrome by flow cytometry and a cone and plate(let) analyzer (Impact-R). Transfusion 2007; 47: 103-106. (Pubitemid 46006316)
31. Panzer S, Badr Eslam R, Schneller A, et al. Loss of high-molecular-weight von Willebrand factor multimers mainly affects platelet aggregation in patients with aortic stenosis. Thromb Haemost 2010; 103: 408-414.
32. Ikeda Y, Handa M, Kamata T, et al. Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation. Thromb Haemost 1993; 69: 496-502. (Pubitemid 23146447)
33. Reiter N, Eichelberger B, Kaider A, et al. Thrombin-inducible platelet adhesion and regulation of the platelet seven-transmembrane thrombin receptor-1 (PAR-1): effects of unfractionated heparin and lepirudin. Platelets 2009; 20: 582-587.