Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin

Heart

Volumn 92, Issue 11, 2006, Pages 1635-1638

  Harding, S A ^a   Din, J N ^a   Sarma, J ^a   Josephs, D H ^a   Fox, K A A ^a   Newby, David ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; ENOXAPARIN; HEPARIN; HIRULOG; LEPIRUDIN; PADGEM PROTEIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MONOCYTE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION;

ADULT; ANTICOAGULANTS; CELL AGGREGATION; ENOXAPARIN; HEPARIN; HIRUDINS; HUMANS; MONOCYTES; P-SELECTIN; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; RECOMBINANT PROTEINS; THROMBIN;

EID: 33750380816     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.2005.063917     Document Type: Article

References (30)

1. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001;104:365-72.
2. Sarma J, Laan CA, Alam S, et al. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 2002;105:2166-71.
3. Furman MI, Benoit SE, Barnard MR, et al. Increased platelet reactivity and circulating monocyte-platetet aggregates in patients with stable coronary artery disease. J Am Coll Cardiol 1998;31:352-8.
4. Mickelson JK, Lakkis NM, Villarreal-Levy G, et al. Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease? J Am Coll Cardiol 1996;28:345-53.
5. Rinder CS, Bonan JL, Rinder HM, et al. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992;79:1201-5.
6. Neumann F-J, Marx N, Gawaz M, et al. Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation 1997;95:2387-94.
7. Neumann FJ, Zohlnhofer D, Fakhoury L, et al. Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction. J Am Coll Cardiol 1999;34:1420-6.
8. Celi A, Pellegrini G, Lorenzet R, et al. P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A 1994;91:8767-71.
9. Elstad MR, La Pine TR, Cowley FS, et al. P-selectin regulates platelet-activating factor synthesis and phagocytosis by monocytes. J Immunol 1995;155:2109-22.
10. Weyrich AS, Elstad MR, McEver RP, et al. Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest 1996;97:1525-34.
11. Yago T, Tsukuda M, Minami M. P-selectin binding promotes the adhesion of monocytes to VCAM-1 under flow conditions. J Immunol 1999;163:367-73.
12. Da Costa Martins P, van den Berk N, Ulfman LH, et al. Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation. Arterioscler Thromb Vasc Biol 2004;24:193-9.
13. Frossard M, Fuchs I, Leitner JM, et al. Platelet function predicts myocardial damage in patients with acute myocardial infarction. Circulation 2004;110:1392-7.
14. Kabbani SS, Watkins MW, Ashikaga T, et al. Platelet reactivity characterized prospectively: a determinant of outcome 90 days after percutaneous coronary intervention. Circulation 2001;104:181-6.
15. Thomson C, Forbes CD, Prentice CR. The potentiation of platelet aggregation and adhesion by heparin in vitro and in vivo. Clin Sci Mol Med 1973;45:485-94.
16. Salzman EW, Rosenberg RD, Smith MH, et al. Effect of heparin and heparin fractions on platelet aggregation. J Clin Invest 1980;65:64-73.
17. Heinrich D, Gorg T, Schulz M. Effects of unfractionated and fractionated heparin on platelet function. Haemostasis 1988;18:48-54.
18. Law DA, Nannizzi-Alaimo L, Phillips DR. Outside-in integrin signal transduction: alpha lib beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem 1996;271:10811-5.
19. Sobel M, Fish WR, Toma N, et al. Heparin modulates integrin function in human platelets. J Vasc Surg 2001;33:587-94.
20. Manka D, Forlow SB, Sanders JM, et al. Critical role of platelet P-selectin in the response to arterial injury in apolipoprotein-E-deficient mice. Arterioscler Thromb Vasc Biol 2004;24:1124-9.
21. Petersen JL, Mahaffey KW, Hasselblad V, et al. Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-segment elevation acute coronary syndromes: a systematic overview. JAMA 2004;292:89-96.
22. Goodman SG, Fitchett D, Armstrong PW, for the Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial Investigators, et al. Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Circulation 2003;107:238-44.
23. Cohen M, Demers C, Gurfinkel EP, et al. The efficacy and safety of subcutaneous enoxaparin in non-Q-wave coronary events study group: a comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. N Engl J Med 1997;337:447-52.
24. Direct Thrombin Inhibitor Trialists' Collaborative Group. Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data. Lancet 2002;359:294-302.
25. Lincoff AM, Bittl JA, Harrington RA, et al. The REPLACE-2 Investigators. Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA 2003;289:853-63.
26. Munoz EM, Linhardt RJ. Heparin-binding domains in vascular biology. Arterioscler Thromb Vasc Biol 2004;24:1549-57.
27. Nelson RM, Cecconi O, Roberts WG, et al. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood 1993;82:3253-8.
28. Wang L, Brown JR, Varki A, et al. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest, 2002; 110:127-36.
29. Peter K, Schwarz M, Conradt C, et al. Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18). Circulation 1999;100:1533-9.
30. Cerletti C, Evangelista V, de Gaetano G. P-selectin-beta 2-integrin cross-talk: a molecular mechanism for polymorphonuclear leukocyte recruitment at the site of vascular damage. Thromb Haemost 1999;82:787-93.