Thrombin-inducible platelet adhesion and regulation of the platelet seven-transmembrane thrombin receptor-1 (PAR-1): Effects of unfractionated heparin and lepirudin

Platelets

Volumn 20, Issue 8, 2009, Pages 582-587

  Reiter, Nina ^a   Eichelberger, Beate ^a   Kaider, Alexandra ^a   Panzer, Simon ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Heparin; Lepirudin; PAR 1; Platelet activation; Platelet adherence; Thrombin

Indexed keywords

HEPARIN; LEPIRUDIN; PADGEM PROTEIN; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN;

ADULT; ARTICLE; CONTROLLED STUDY; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REGULATORY MECHANISM; SHEAR STRESS; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

ADULT; ANTICOAGULANTS; BLOOD PLATELETS; HEPARIN; HIRUDINS; HUMANS; MIDDLE AGED; P-SELECTIN; PLATELET ADHESIVENESS; RECEPTOR, PAR-1; RECOMBINANT PROTEINS; THROMBIN; YOUNG ADULT;

EID: 73649117019     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537100903247782     Document Type: Article

References (16)

1. Warkentin TE, Greinacher A, Koster A, Lincoff AM. American College of Chest Physicians. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl): 340S-380S.
2. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest 1999;103:879-887.
3. Leger AJ, Covic L, Kuliopulos A. Protease-activated receptors in cardiovascular diseases. Circulation 2006;114:1070-1077.
4. Dormann D, Clemetson KJ, Kehrel BE. The GPIb thrombinbinding site is essential for thrombin-induced platelet procoagulant activity. Blood 2000;96:2469-2478.
5. Soslau G, Class R, Morgan DA, Foster C, Lord ST, Marchese P, Ruggeri ZM. Unique pathway of thrombininduced platelet aggregation mediated by glycoprotein Ib. J Biol Chem 2001;276:21173-21183.
6. Adam F, Guillin MC, Jandrot-Perrus M. Glycoprotein Ibmediated platelet activation. A signalling pathway triggered by thrombin. Eur J Biochem 2003;270:2959-2970.
7. Jurk K, Jahn UR, Van Aken H, Schriek C, Droste DW, Ritter MA, Bernd Ringelstein E, Kehrel BE. Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1). Thromb Haemost 2004;91: 334-344.
8. Yano Y, Ohmori T, Hoshide S, Madoiwa S, Yamamoto K, Katsuki T, Mitsuhashi T, Mimuro J, Shimada K, Kario K, et al. Determinants of thrombin generation, fibrinolytic activity, and endothelial dysfunction in patients on dual antiplatelet therapy: involvement of factors other than platelet aggregability in Virchow's triad. Eur Heart J 2008;29: 1729-1738.
9. Greinacher A, Warkentin TE. The direct thrombin inhibitor hirudin. Thromb Haemost 2008;99:819-829.
10. Xiao Z, Theroux P. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor. Circulation 1998;97:251-256.
11. Keating FK, Dauerman HL, Whitaker DA, Sobel BE, Schneider DJ. Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin. Thromb Res 2006;118:361-369.
12. Harding SA, Din JN, Sarma J, Josephs DH, Fox KA, Newby DE. Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin. Heart 2006;92:1635-1638.
13. Shenkman B, Einav Y, Salomon O, Varon D, Savion N. Testing agonist-induced platelet aggregation by the Impact-R [Cone and plate(let) analyzer (CPA)]. Platelets 2008;19: 440-446.
14. Revel-Vilk S, Hyam E, Zelikowitz T, Shai E, Varon D. Evaluation of children with suspected bleeding disorder applying the Impact-R [Cone and Plate(let) Analyzer]. Blood 2007;110:Abstract 3962.
15. Dardik R, Varon D, Eskaraev R, Tamarin I, Inbal A. Recombinant fragment of von Willebrand factor AR545C inhibits platelet binding to thrombin and platelet adhesion to thrombin-treated endothelial cells. Brit J Haematol 2000;109:512-518.
16. Panzer S, Eichelberger B, Koren D, Kaufmann K, Male C. Monitoring survival and function of transfused platelets in Bernard-Soulier syndrome by flow cytometry and a cone and plate(let) analyzer (Impact-R). Transfusion 2007;47:103-106.