IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency

Scandinavian Journal of Immunology

Volumn 45, Issue 2, 1997, Pages 203-212

  Punnonen, J ^a,b   Kainulainen, L ^c   Ruuskanen, O ^c   Nikoskelainen, J ^c   Arvilommi, H ^d  

^a Universität Turku   (Finland)

^b MERCK RESEARCH LABORATORIES   (United States)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE DIFFERENTIATION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0031024697     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-381.x     Document Type: Article

References (56)

1. Sneller MC, Strober W, Eisenstein E, Jaffe JS, Cunningham-Rundles C. NIH Conference. New insights into common variable immunodeficiency. Ann Intern Med 1993;118:720-30.
2. Rosen FS, Cooper MD, Wedgwood RJP. The primary immunodeficiencies. N Engl J Med 1995;333:431-40.
3. Liu YJ, Johnson GD, Gordon J, MacLennan IC. Germinal centres in T-cell-dependent antibody responses. Immunol Today 1992;13: 17-21.
4. De Vries JE, Punnonen J, Cocks B, Aversa G. The role of T-B cell interactions and cytokines in the regulation of human IgE synthesis. Semin Immunol 1993;5:431-9.
5. Coffman RL, Lehman DA, Rothman P. Mechanism and regulation of immunoglobulin isotype switching. Adv Immunol 1993;54:229-70.
6. Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992;357:80-2.
7. Hollenbaugh D, Grosmaire LS, Kullas CD et al. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J 1992;11:4313-21.
8. Allen RC, Armitage RJ, Conley ME et al. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 1993;259: 990-3.
9. Di Santo JP, Bonnefoy JY, Gauchat JF, Fischer A, De Saint Basile G. CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM. Nature 1993;361:541-3.
10. Fuleihan R, Ramesh N, Loh R et al. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc Natl Acad Sci USA 1993;90: 2170-3.
11. Aruffo A, Farrington M, Hollenbaugh D et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell 1993;72:291-300.
12. Aversa G, Punnonen J, De Vries JE. The 26-kD transmembrane form of tumor necrosis factor alpha on activated CD4+ T cell clones provides a costimulatory signal for human B cell activation. J Exp Med 1993;177:1575-85.
13. Macchia D, Almerigogna F, Parronchi P, Ravina A, Maggi E, Romagnani S. Membrane tumour necrosis factor-alpha is involved in the polyclonal B-cell activation induced by HIV-infected human T cells. Nature 1993;363:464-6.
14. Rickert RC, Rajewsky K, Roes J. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 1995;376:352-5.
15. Life P, Gauchat JF, Schnuriger V et al. T cell clones from an X-linked hyper-immunoglobulin (IgM) patient induce IgE synthesis in vitro despite expression of nonfunctional CD40 ligand. J Exp Med 1994;180:1775-84.
16. Farrington M, Grosmaire LS, Nonoyama S et al. CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc Natl Acad Sci USA 1994;91:1099-103.
17. Eisenstein EM, Chua K, Strober W. B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10. J Immunol 1994;152:5957-68.
18. Pastorelli G, Roncarolo MG, Touraine JL, Peronne G, Tovo PA, De Vries JE. Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interteron-gamma, but proliferate normally upon activation by mitogens. Clin Exp Immunol 1989;78: 334-40.
19. Sneller MC, Strober W. Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency. J Immunol 1990;144:3762-9.
20. Fuchs D, Weiss G, Murr C, Wachter H. Interleukin-10 for common variable immunodeficiency. Lancet 1993;342:1363.
21. Zielen S, Bauscher P, Hofmann D, Meuer SC. Interleukin 10 and immune restoration in common variable immunodeficiency. Lancet 1993;342:750-1.
22. Pandolfi F, Paganelli R, Oliva A et al. Increased IL-6 gene expression and production in patients with common variable immunodeficiency. Clin Exp Immunol 1993;92:239-44.
23. Adelman DC, Matsuda T, Hirano T, Kishimoto T, Saxon A. Elevated serum interleukin-6 associated with a failure in B cell differentiation in common variable immunodeficiency. J Allergy Clin Immunol 1990;86:512-21.
24. Cunningham-Rundles C, Kazbay K, Hassett J, Zhou Z, Mayer L. Brief report: enhanced humoral immunity in common variable immunodeficiency after long-term treatment with polyethylene glycol-conjugated interleukin-2. N Engl J Med 1994;331:918-21.
25. Czerkinsky CC, Nilsson LA, Nygren H, Ouchterlony O, Tarkowski A. A solid-phase enzyme-linked immunospot (ELISPOT) assay for the enumeration of specific antibody-secreting cells. J Immunol Methods 1983;65:109-21.
26. Kantele A, Papunen R, Virtanen E et al. Antibody-secreting cells in urinary tract infection as indicators of local immune response. J Infect Dis 1994;169:1023-8.
27. Sedgwick JD, Holt PG. A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J Immunol Methods 1995;57:301-9.
28. Viljanen MK. Punnonen J. The effect of storage of antigen-coated polystyrene microwells on the detection of antibodies against Borrelia burgdorferi by enzyme immunoassay (EIA). J Immunol Methods 1989;124:137-41.
29. Punnonen J. The role of interleukin 2 in the regulation of proliferation and IgM synthesis of human newborn mononuclear cells. Clin Exp Immunol 1989;75:421-6.
30. Yano M, Kondo N, Kato Y, Shinoda S, Inoue R, Orii T. Expression of surrogate light chain in common variable immunodeficiency. Exp Clin Immunogenet 1995;12:1-9.
31. +T cells or their membranes. Blood 1993;82:2781-9.
32. Rolink A, Melchers F. Molecular and cellular origins of B lymphocyte diversity. Cell 1991;66:1081-94.
33. Ruuskanen O, Pittard III WB, Miller K, Pierce G, Sorensen RU, Polmar SH. Staphylococcus aureus Cowan I-induced immunoglobulin production in human cord blood lymphocytes. J Immunol 1980;125:411-7.
34. Andersson U, Bird AG, Britton S, Palacios R. Humoral and cellular immunity in humans studied at the cell level from birth to two years of age. Immunol Rev 1981;57:5-27.
35. Butler JL, Suzuki T, Kubagawa H, Cooper MD. Humoral immunity in the human neonate. In: Burgio GR, Hanson LA, Ugazio AG, eds. Immunology of the Neonate. Berlin: Springer-Verlag, 1987:27-49.
36. Nonoyama S, Farrington M, Howard M, Ochs HD. Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin. J Clin Invest 1995;92:1282-7.
37. Clark EA, Ledbetter JA. Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc Natl Acad Sci USA 1986;83:4494-8.
38. + T cell clones and IL-4 induce lgG4 and IgE switching in purified human B cells via different signaling pathways. J Immunol 1991;147:8-13.
39. Jabara HH, Fu SM, Geha RS, Vercelli D. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J Exp Med 1990;172:1861-4.
40. + T lymphocyte subsets in patients with common variable immunodeficiency. Clin Immunol Immunopathol 1991;61:83-92.
41. Baumert E, Wolff-Vorbeck G, Schlesier M, Peter HH. Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID). Clin Exp Immunol 1992;90:25-30.
42. + lymphocytopenia due to common variable immunodeficiency mimicking AIDS. J Clin Pathol 1994;47:364-6.
43. + T lymphocytes provide helper activity for IgE synthesis in human immunodeficiency virus-infected patients with hyper-IgE. J Exp Med 1995;181:423-8.
44. + T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection. J Exp Med 1994; 180:489-95.
45. Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992;357:80-2.
46. Spriggs MK, Armitage RJ, Strockbine L et al. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J Exp Med 1992;176:1543-50.
47. Cocks BG, de Waal Malefyt R, Galizzi JP, De Vries JE, Aversa G. IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand. Int Immunol 1993;5:657-63.
48. Zurawski G, De Vries JE. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994;15:19-26.
49. Punnonen J, Aversa G, Cocks BG et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993;90: 3730-4.
50. de Waal Malefyt R, Figdor CG, Huijbens R et al. Effects of IL-13 on phenotype, cytokine production, and cytoloxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10. J Immunol 1993;151:6370-81.
51. Punnonen J, De Vries JE, IL-13 induces proliferation, Ig isotype switching, and Ig synthesis by immature human fetal B cells. J Immunol 1994;152:1094-102.
52. Russell SM, Keegan AD, Harada N et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 1993;262:1880-3.
53. Kondo M, Takeshita T, Ishii N et al. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science 1993;262:1874-7.
54. Lin JX, Migone TS, Tsang M et al. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 1995;2:331-9.
55. He YW, Malek TR. The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor. J Immunol 1995; 155:9-12.
56. Matthews DJ, Clark PA, Herbert J et al. Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15. Blood 1995;85:38-42.