Defective surface expression of attractin on T cells in patients with common variable immunodeficiency (CVID)

Clinical and Experimental Immunology

Volumn 123, Issue 1, 2001, Pages 99-104

  Pozzi, N ^a   Gaetaniello, L ^a   Martire, B ^b   De Mattia, D ^b   Balestrieri, B ^a   Cosentini, E ^a   Schlossman, S F ^c   Duke Cohan, J S ^c   Pignata, Claudio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Attractin; Common variable immunodeficiency; Signal transduction; T cell activation

Indexed keywords

ATTRACTIN; CD3 ANTIGEN; DIPEPTIDYL PEPTIDASE IV; INTERLEUKIN 2 RECEPTOR; RECOMBINANT INTERLEUKIN 2; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOLOGY; MALE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCHOOL CHILD; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADULT; ANTIGENS, CD19; ANTIGENS, CD26; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD8; BIOLOGICAL MARKERS; CELL MEMBRANE; CHILD; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 0035140533     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01413.x     Document Type: Article

References (27)

1. Primary immunodeficiency diseases
2. Common variable immunodeficiency: How many diseases?
3. CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency
4. Immunologic responses to bacteriophage phi-X 174 in immunodeficiency diseases
5. Clinical and immunologic analyses of 103 patients with common variable immunodeficiency
6. Immunoglobulins on the surface of lymphocytes in fifty patients with primary immunodeficiency diseases
7. Three distinct stages of B-cell defects in common varied immunodeficiency
8. Quantitative measurements of T- and B-cell function in 'variable' primary hypogammaglobulinaemia: Evidence for a consistent B-cell defect
9. Polyclonal immunoglobulin secretion in patients with common variable immunodeficiency using monoclonal B cell differentiation factors
10. Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin
11. Reduced interleukin-2 (IL-2) production in common variable immunodeficiency is due to a primary abnormality of CD4+ T cell differentiation
12. Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients
13. Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency
14. Uncoupling of T-cell antigen receptor and downstream protein tyrosine kinases in common variable immunodeficiency
15. Antigen-presenting cell types
16. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
17. Signals and signs for lymphocyte responses
18. Antigen presentation by common variable immunodeficiency (CVID) and monocytes is unimpaired
19. Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions
20. Secreted and membrane attractin result from alternative splicing of the human ATRN gene
21. The mouse mahogany gene encodes a transmembrane form of human attractin
22. A novel form of CD26/dipeptidylpeptidase IV found in human serum: Isolation, characterization and comparison with T lymphocyte membrane CD26
23. Enhancement of antigen-induced T-cell proliferation by soluble CD26/dipeptidyl peptidase IV
24. Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells
25. T-cell abnormalities in common variable immunodeficiency
26. Defective integration, of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4+ and CD8+ T lymphocytes of common variable immunodeficiency (CVID) patients
27. Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency