Development of sulfonamide AKT PH domain inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 2046-2054

  Ahad, Ali Md ^a   Zuohe, Song ^b   Du Cuny, Lei ^d   Moses, Sylvestor A ^c   Zhou, Li Li ^a   Zhang, Shuxing ^d   Powis, Garth ^d   Meuillet, Emmanuelle J ^b,c   Mash, Eugene A ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c University of Arizona   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

AKT; Anticancer; Drug design; Drug development; PH domain

Indexed keywords

2 (5 (4 DODECYLPHENYLSULFONAMIDO) 1,3,4 THIADIAZOL 2 YL)ACETIC ACID; 4 BUTYL N (1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 DODECYL N (1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 DODECYL N (5 (HYDROXYMETHYL) 1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 DODECYL N (5 ETHYL 1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 DODECYL N (5 METHYL 1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 HEXADECYL N (1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 HEXYL N (1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 OCTADECYL N (1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 OCTYL N (1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 4 TETRADECYL N (1,3,4 THIADIAZOL 2 YL)BENZENESULFONAMIDE; 5 (4 DODECYLPHENYLSULFONAMIDO) 1,3,4 THIADIAZOL 2 SULFONAMIDE; ETHYL 2 (5 (4 DODECYLPHENYLSULFONAMIDO) 1,3,4 THIADIAZOL 2 YL)ACETATE; ETHYL 5 (4 DODECYLPHENYLSULFONAMIDO) 1,3,4 THIADIAZOL 2 CARBOXYLATE; N (5 TERT BUTYL 1,3,4 THIADIAZOL 2 YL) 4 DODECYLBENZENESULFONAMIDE; PLECKSTRIN; PROTEIN KINASE B; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MELTING POINT; MOLECULAR DOCKING; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; HUMANS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 79952439090     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.049     Document Type: Article

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