Self emulsifying drug delivery system: A conventional and alternative appproach to improve oral bioavailability of lipophilic drugs

International Journal of Drug Development and Research

Volumn 2, Issue 4, 2010, Pages 859-870

  Patel, Vipul P ^a   Desai, Tushar R ^a   Kapupara, Pankaj P ^b   Atara, Samir A ^a   Keraliya, Rajesh A ^c  

^a R K College of Pharmacy   (India)

^b Jodhpur National University   (India)

^c Kalol Institute of Pharmacy   (India)

Author keywords

Biopharmaceutical systems; Drug delivery system for lipophilic drugs; Insoluble drug delivery system; Self emulsifying drug delivery system

Indexed keywords

ACETYLSALICYLIC ACID; ACYLGLYCEROL; ALCOHOL; ALPHA TOCOPHEROL; ARACHIS OIL; COCONUT OIL; CORN OIL; CREMOPHOR; DEXTRO ALPHA TOCOPHERYL POLYETHYLENE GLYCOL 1000 SUCCINATE; EMULSIFYING AGENT; GALACTICLES; GLYCEROL; HYDROGENATED VEGETABLE OIL; KETOPROFEN; MACROGOL; NONIONIC SURFACTANT; OLEIC ACID; OLIVE OIL; PALM SEED OIL; POLYOXYETHYLATED GLYCERIDE; POLYSORBATE 20; POLYSORBATE 80; PROPOLIS; PROPYLENE GLYCOL; SESAME SEED OIL; SOLVENT; SORBITAN OLEATE; SOYBEAN OIL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VEGETABLE OIL;

ADSORPTION; ARTICLE; BIODEGRADATION; CONTROLLED DRUG RELEASE; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG GRANULATION; DRUG MANUFACTURE; DRUG RESEARCH; DRUG SOLUBILITY; DRUG TARGETING; ELECTRIC CONDUCTIVITY; EMULSION; EXTRUSION SPHERONIZATION; GASTROINTESTINAL TRACT; HYDROPHILICITY; LIPOPHILICITY; MELT GRANULATION; PARTICLE SIZE; REFRACTION INDEX; SELF EMULSIFICATION; SPHERONIZATION; SPRAY DRYING; THERMOSTABILITY; TURBIDIMETRY;

EID: 79952415599     PISSN: None     EISSN: 09759344     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. G.L. Amidon, H Lennernas, V. P. Shah, J. R. Criston. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 1995; 12 Suppl 3: 413-420.
2. B.J. Aungst. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J. Pharm. Sci. 1993; 82: 979-986.
3. D.L. Burcham, M.B Maurin, E.A. Hausner, S.M.Haung. Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions. Biopharm. Drug Dispos. 1997; 18 Suppl 8: 737-742. (Pubitemid 27475189)
4. A.T. Serajuddin, P.C. Sheen, D. Mufson, D.F. Burnstein, M.A. Augustine. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water soluble drug from solid dispersion. J. Pharm. Sci. 1988; 77 Suppl 5: 414-417. (Pubitemid 19080862)
5. B.J. Aungst, N. Nguyen, N.J. Rogers, S. Rowe, M. Improved oral bioavailability of an HIV protease inhibitor using Gelucire 44/14 and Labrasol vehicles. B.T. Gattefosse 1994; 87: 49-54.
6. M.G. Wakerly, C.W. Pouton, B.J. Meakin, F.S. Morton. Self-emulsification of vegetable oil-non-ionic surfactant mixtures. ACS Symp. Ser. 1986; 311: 242-255.
7. D.Q.M. Craig, H.S.R. Leivens, K.G.Pitt, D.E. Storey. An investigation into the physicochemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis. Int. J. Pharm. 1993; 96 Suppl 1-3: 147-155. (Pubitemid 23233280)
8. H. Toguchi, Y. Ogawa, K. Iga, T. Yashiki, T. Shimamoto. Gastrointestinal absorption of ethyl 2 chloro-3-(4-(2-methyl-2-phenylpropyloxy) phenyl) propionate from different dosage forms in rats and dogs. Chem. Pharm. Bull. 1990; 38: 2792-2796. (Pubitemid 20386053)
9. T.T. Kararli, T.E. Needham, M. Griffin, G. Schoenhard, L.J. Ferro, L. Alcorn. Oral delivery of a renin inhibitor compound using emulsion formulations. Pharm. Res. 1992; 9 Suppl 7: 888-893.
10. R.A. Schwendener, H. Schott. Lipophilic 1-beta-Darabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model. J. Cancer Res. Clin. Oncol. 1996; 122: 723-726. (Pubitemid 26393240)
11. Gursoy, R.N. and Benita, S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed. Pharmacother 2004; 58:173-182. (Pubitemid 38479922)
12. Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004; 58: 173-82. (Pubitemid 38479922)
13. Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000; 50:179-88. (Pubitemid 30326696)
14. Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Selfemulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm 1994; 106:15-23. (Pubitemid 24110060)
15. Craig DQM, Lievens HSR, Pitt KG, Storey DE. An investigation into physico-chemical properties of selfemulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis. Int J Pharm 1993;96: 147-55. (Pubitemid 23233280)
16. Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko FJ, Pouton CW. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm Res 1992; 9:87-93.
17. Amidon GL, Lennernas H, Shah VP, Crison JRA. Theoretical basis for a biopharmaceutical classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res, 1995; 12 Suppl 3: 413-420.
18. P.P. Constantinides. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects, Pharm. Res 1995; 12 Suppl 11: 1561-72. (Pubitemid 26005509)
19. Reiss H. Entropy- induced dispersion of bulk liquid. Journal of colloidal interface Sciences, 1975; 53: 61-70.
20. Groves MJ, Mustafa RMA. Measurement of spontaneity of self emulsifiable oils. J. Pharm Pharmacol. 1974; 26: 671-688.
21. Groves MJ, Mustafa RMA,.Carless JE. Phase studies of mixed surfactants n-hexane and water. J. Pharm Pharmacol, 1974; 26: 616-623.
22. Pouton CW. Formulation of self-emulsifying drug delivery system. Adv. Drug Del. Rev. 1997; 25: 47-58. (Pubitemid 27107790)
23. Friedman D. Non-aqueous compositions for oral delivery of insoluble bioactive agents. US Pat 20070190080.
24. R.N. Gursoy and S. Benita. Self-emulsifying drug delivery systems for improved oral delivery of lipophilic drugs. Biomedicine and Pharmacotherapy 2004; 58:173-182. (Pubitemid 38479922)
25. S.M. Khoo, A.J. Humberstone, Christopher JH porter, Glen A. Edwards, William N. Charman. Formulation design and bioavailability assessment of lipidic self-emulsifying formulation of halofanitrine. International Journal of Pharmaceutics 1998; 167 Suppl 1-2: 155-164. (Pubitemid 28341517)
26. P.P. Constantinides. Lipid microemulsion for improving drugs dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995; 12 Suppl 11: 1561-1572. (Pubitemid 26005509)
27. N.H. Shah, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int. J. Pharm.1994; 106: 15-23. (Pubitemid 24110060)
28. Grove M., Mullertz A, Nielsen Jeanet, Pedersen G. Bioavailability of seocalcitol II: development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides . Eur J Pharm Sci. 2006; 28 Suppl 3: 233-242. (Pubitemid 43766097)
29. Bo Tang, Gang Cheng, Jian-Chun Gu and Cai-Hong Xu. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discovery Today 2008; 13 Suppl 14: 1-7.
30. Ito Y., Kusawake t., Ishida M., Tawa R., Shibata N., Takada K. Oral solid gentamicin preparation using emulsifier and adsorbent. J. Control Release 2005; 105, 23-31. (Pubitemid 40812359)
31. Boltri L., Coceani L., De Curto D, Dobetti L., Esposito P. Enhancement and modification of etoposide release from crospovidone particles loaded with oil-surfactant blends. Pharm. Dev. Technol. 1997; 2 Suppl 4: 373-381. (Pubitemid 28249302)
32. Venkatesan N., Yoshimitsu J., Ito Y., Shibata N., Takada K. Liquid filled nanoparticles as a drug delivery tool for protein therapeutics. Biomaterials 2005; 26 Suppl 34, 7154-7163. (Pubitemid 41095538)
33. PA Patel, GM Chaulang , A Akolkotkar, SS Mutha, SR Hardikar and AV Bhosale. Self Emulsifying Drug Delivery System: A Review. Research J. Pharm. and Tech. 2008; 1 Suppl 4(4): 1-11.
34. S. Shafiq, F. Shakeel, S. Talegaunker, FJ Ahmed, R.K. Khar, M. Ali. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur. J. Pharm. Biopharm 2007; 66: 227-243. (Pubitemid 46667230)
35. Patil P, Joshij, paradkar. Effect of formulatiuon variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of ketoprofen. AAPS Pharm Sci Tech.2004;5(3):34-42.
36. Patil P, Vandana P, Paradkar P. Formulation of selfemulsifying drug delivery system for oraldelivery of simvastatin:In vitro and in vivo evaluation. Acta pharma. 2007;57: 111-122. (Pubitemid 46361952)
37. Jessy Shaji and Vishvesh Joshi. Self-Micro Emulsifying Drug Delivery System (SMEDDS) for Improving Bioavailability of Hydrophobic Drugs and its Potential to give Sustain Release Dosage Form. Indian Journal of pharm. Edu. 2005; 39 Suppl 5: 130-135.
38. Bhupendra G. Prajapati and Madhabhai M. Patel. Conventional and alternative pharmaceutical methods to improve oral bioavailability of lipophilic drugs. Asian journal of pharmaceuticssvolume 2007; 1 Suppl 1: 1-8.
39. Vergote GJ, Vervaet C., Van DI, Hoste S., De Smedt S., Demeester J., Jain RA, Ruddy S, Remon JP. An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen. Int J Pharm. 2001; 219 Suppl 1-2: 81-87. (Pubitemid 32391367)
40. El-Kamel AH, Sokar MS, Al Gamal SS.,Nagar VF . Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm. 2001; 220:13-21. (Pubitemid 32476837)
41. Rhee YS, Choi JG, Park ES, Chie SC. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm. 2001; 228 Suppl 1-2:161-170.
42. Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm.1994; 106:15-23. (Pubitemid 24110060)