Common variants near MC4R: Exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention

Obesity Facts

Volumn 4, Issue 1, 2011, Pages 67-75

  Vogel, Carla I G ^a,e   Boes, Tanja ^a   Reinehr, Thomas ^b   Roth, Christian L ^c,d   Scherag, Susann ^a   Scherag, André ^a   Hebebrand, Johannes ^a   Hinney, Anke ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF BONN   (Germany)

^e UNIVERSIDADE DO PLANALTO CATARINENSE   (Brazil)

Author keywords

BMI SDS reduction; Insulin; MC4R; Metabolism markers; Obesity

Indexed keywords

INSULIN; MELANOCORTIN 4 RECEPTOR;

ADOLESCENT; ALLELE; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLLOW UP; HUMAN; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; OBESITY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SCHOOL CHILD; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; BLOOD PRESSURE; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; INSULIN; LIFE STYLE; MALE; OBESITY; OVERWEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MELANOCORTIN, TYPE 4; SEX FACTORS;

EID: 79952384663     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000324557     Document Type: Article

References (28)

1. Hinney A, Bettecken T, Tarnow P, Brumm H, Reichwald K, Lichtner P, Scherag A, Nguyen TT, Schlumberger P, Rief W, Vollmert C, Illig T, Wichmann HE, Sch?er H, Platzer M, Biebermann H, Meitinger T, Hebebrand J: Prevalence, spectrum and functional characterization of melanocortin4 receptor gene mutations in a representative population- based sample and obese adults from Germany. J Clin Endocrinol Metab 2006;91:1761-1769.
2. Geller F, Reichwald K, Dempfle A, Illig T, Vollmert C, Herpertz S, Siffert W, Platzer M, Hess C, Gudermann T, Biebermann H, Wichmann HE, Sch?er H, Hinney A, Hebebrand J: Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 2004;74:572-581. (Pubitemid 38325928)
3. Dempfle A, Hinney A, Heinzel-Gutenbrunner M, Raab M, Geller F, Gudermann T, Sch?er H, Hebebrand J: Large quantitative effect of melanocortin- 4 receptor gene mutations on body mass index. J Med Genet 2004;41:795-800. (Pubitemid 39389299)
4. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40:768-775. (Pubitemid 351748863)
5. Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, Balding D, Scott J, Kooner JS: Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 2008;40:716-718. (Pubitemid 351748872)
6. Renstr? F, Payne F, Nordstr? A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordstr? P, Franks PW; GIANT Consortium: Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 2009;18:1489-1496.
7. Jacobsson JA, Danielsson P, Svensson V, Klovins J, Gyllensten U, Marcus C, Schi?h HB, Fredriksson R: Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun 2008;368:476-482.
8. Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, D?ing A, Rkert IM, Hinney A, Hebebrand J, Wichmann HE, Hauner H, Illig T, Heid IM: Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA. Int J Obes (Lond) 2010; DOI: 10.1038/ijo.2010.79.
9. Patsopoulos NA, Tatsioni A, Ioannidis JP: Claims of sex differences: an empirical assessment in genetic associations. JAMA 2007;298:880-893. (Pubitemid 47311294)
10. Cole TJ: The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990;44: 45-60. (Pubitemid 20177198)
11. Kromeyer-Hauschild K, Wabitsch M, Geller F, Ziegler A, Gei? HC, Hesse V, von Hippel, Jaeger U, Johnsen D, Kiess W, Korte W, Kunze D, Menner K, Mler G, Mler M, Niemann-Pilatus A, Remer TH, Schaefer F, Wittchen HU, Zabransky S, Zellner K, Hebebrand J: Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd 2001;149:807-818. (Pubitemid 32830649)
12. Roth CL, Hinney A, Reinehr T, Schreiner F, Nguyen TT, Mler T, Scholl C, Woelfle J, Karpushova A, Sch?er H, N?hen MM, Hebebrand J: TCF7L2 polymorphism rs7903146 and predisposition to type 2 diabetes mellitus in obese children. Horm Metab Res 2008,40:713-717.
13. Reinehr T, Hinney A, de Sousa G, Austrup F, Hebebrand J, Andler W: Definable somatic disorders in overweight children and adolescents. J Pediatrics 2007;150:618-622.
14. Hinney A, Nguyen TT, Scherag A, Friedel S, Br?ner G, Mler TD, Grallert H, Illig T, Wichmann HE, Rief W, Sch?er H, Hebebrand J: Genome Wide Association (GWA) Study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PloS ONE 2007;2:e1361.
15. Reinehr T, de Sousa G, Toschke M, Andler W: Long-term follow-up of cardiovascular risk factors in obese children after intervention. Am J Clin Nutr 2006;84:490-496. (Pubitemid 44713397)
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419. (Pubitemid 15018832)
17. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH: Establishing a standard definition for child overweight and obesity world-wide: international survey. BMJ 2000;320:1240-1243. (Pubitemid 30240471)
18. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents: The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-576.
19. Farooqi S, O'Rahilly S: Monogenic obesity in humans. Annu Rev Med 2005,56:443-458.
20. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S: Clinical spectrum of obesity and mutations in the melanocortin 4 r ceptor gene. N Engl J Med 2003;348:1085-1095. (Pubitemid 36337319)
21. Reinehr T, Hebebrand J, Friedel S, Toschke AM, Brumm H, Biebermann H, Hinney A: Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity (Silver Spring) 2009;17:382-389.
22. Haupt A, Thamer C, Heni M, Tschritter O, Machann J, Schick F, Machicao F, H?ing HU, Staiger H, Fritsche A: Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss. Obesity (Silver Spring) 2009;17:1942-1945.
23. Zobel DP, Andreasen CH, Grarup N, Eiberg H, S?ensen TI, Sandb? A, Lauritzen T, Borch- Johnsen K, J?gensen T, Pedersen O, Hansen T: Variants near MC4R associate with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. Diabetes 2008;58:757-764.
24. Been LF, Nath SK, Ralhan SK, Wander GS, Mehra NK, Singh J, Mulvihill JJ, Sanghera DK: Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity (Silver Spring) 2010; 18:425-429.
25. Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, Lomas DJ, O'Rahilly S, Farooqi IS: Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med 2009; 360:44-52.
26. Sayk F, Heutling D, Dodt C, Iwen KA, Wellhoner JP, Scherag S, Hinney A, Hebebrand J, Lehnert H: Sympathetic function in human carriers of melanocortin- 4 receptor gene mutations. J Clin Endocrinol Metab 2010;95:1998-2002.
27. Timpson NJ, Harbord R, Davey Smith G, Zacho J, Tybjaerg-Hansen A, Nordestgaard BG: Does greater adiposity increase blood pressure and hypertension risk? Mendelian randomization using the FTO/MC4R genotype. Hypertension 2009;54: 84-90.
28. Hainerov I, Larsen LH, Holst B, Finkov M, Hainer V, Lebl J, Hansen T, Pedersen O: Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis. J Clin Endocrinol Metable 2007;92:3689-3696. (Pubitemid 47435357)