Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus

Science

Volumn 272, Issue 5269, 1996, Pages 1811-

  Morahan, Grant ^a   Huang, Dexing ^a   Tait, Brian D ^a   Colman, Peter G ^a   Harrison, Leonard C ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN BINDING PROTEIN;

ANIMAL MODEL; ARTICLE; CHROMOSOME 2Q; DISEASE PREDISPOSITION; FEMALE; GENE MAPPING; HIGH RISK POPULATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCREENING TEST;

EID: 15844421728     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5269.1811     Document Type: Article

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44. DNA was collected from 25 multiplex families from the Melbourne Prediabetes Family Study. IDDM subjects fulfilled World Health Organization criteria and were dependent on daily insulin injections. Additional samples from 15 families were provided by N Okech, N. Howard, and J. Knight, and DNA from 22 families was obtained from the British Diabetes Association Warren Repository. Each family member was typed at the indicated chromosome 2 marker. Microsatellite markers were analyzed as described (23) with oligonucleotide primers obtained from Research Genetics (Huntsville, AL). Polymorphisms associated with structural geries were detected as described: CTLA4 (13), VIL-D2S1471 (9), and IRS1 (13). CD28 is within 150 kb of CTLA4, whereas NRAMP and IL8R have been mapped close to VIL (13) In some instances, alleles at D2S137 and D2S301 were determined by haplotyping.
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46. We thank C Steele for obtaining samples; M. C. Honeyman for assembling HLA data; S. Foote for helpful discussions and for providing YACs; J. Knight, N. Okech, and N. Howard for supplying DNA samples and HLA data from multiplex IDDM families, and those investigators who provided probes. Supported by the National Health & Medical Research Council of Australia, the Rebecca Cooper Foundation, the Victorian Health Promotion Foundation, the lan Porter Foundation, and Hoechst Australia and Diabetes Australia