Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1744-1747

  Nagata, Naoya ^a   Miyakawa, Motonori ^a   Amano, Seiji ^a   Furuya, Kazuyuki ^a   Yamamoto, Noriko ^a   Inoguchi, Kiyoshi ^a  

^a KAKEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Four point pharmacophore requirement; Grieco 3CC; Nonsteroidal AR agonist; SARM; THQ

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; PROGESTERONE RECEPTOR; QUINOLINE DERIVATIVE; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VIVO STUDY; NONHUMAN; PHARMACOPHORE; RAT;

DRUG DESIGN; MODELS, MOLECULAR; QUINOLINES; RECEPTORS, ANDROGEN;

EID: 79952363708     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.073     Document Type: Article

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