RDX binds to the GABAA receptor-convulsant site and blocks GABAA receptor-mediated currents in the Amygdala: A mechanism for RDX-induced seizures

Environmental Health Perspectives

Volumn 119, Issue 3, 2011, Pages 357-363

  Williams, Larry R ^a   Aroniadou Anderjaska, Vassiliki ^b,c   Qashu, Felicia ^b   Finne, Huckelberry ^c   Pidoplichko, Volodymyr ^b   Bannon, Desmond I ^a   Braga, Maria F M ^b,c  

^a US Army Public Health Command   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c Uniformed Services University of the Health Sciences   (United States)

Author keywords

Amygdala; GABAA currents; GABAA receptors; RDX; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACETYLCHOLINESTERASE; CYCLONITE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN LEVEL; CONTROLLED STUDY; EPILEPTOGENESIS; GABAERGIC TRANSMISSION; INHIBITORY POSTSYNAPTIC POTENTIAL; LIMBIC SYSTEM; MALE; MYOCLONUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SEIZURE; SYNAPTIC TRANSMISSION; TONIC CLONIC SEIZURE;

AMYGDALA; ANIMALS; CONVULSANTS; ENVIRONMENTAL POLLUTANTS; EXPLOSIVE AGENTS; GABA-A RECEPTOR ANTAGONISTS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES; SYNAPTIC POTENTIALS; TRIAZINES;

RATTUS;

EID: 79952349840     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002588     Document Type: Article

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