Characterization of [ 35S]t-butylbicyclophosphorothionate ([ 35S]TBPS) binding to GABA A receptors in postmortem human brain

British Journal of Pharmacology

Volumn 150, Issue 8, 2007, Pages 1066-1074

  Atack, J R ^a,b,d   Ohashi, Y ^a   McKernan, R M ^a,c  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b Sanford Burnham Medical Research Institute   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d Johnson and Johnson PRD   (United States)

Author keywords

35S TBPS; Allosteric modulation; Benzodiazepine; Convulsant binding site; GABA A receptor; Postmortem human brain

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; ANTICONVULSIVE AGENT; BENZODIAZEPINE; DIAZEPAM; FLUMAZENIL; LORECLEZOLE; MUSCIMOL; PENTOBARBITAL; PICROTOXIN; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; CONVULSANT AGENT; FUSED HETEROCYCLIC RINGS; LIGAND; SULFUR; TERT-BUTYLBICYCLOPHOSPHOROTHIONATE; UNCLASSIFIED DRUG;

ADULT; AGED; ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CADAVER; CONTROLLED STUDY; DRUG BINDING SITE; FEMALE; HUMAN; HUMAN TISSUE; LIGAND BINDING; MALE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RAT; ANIMAL; BINDING COMPETITION; BINDING SITE; BRAIN; BRAIN CORTEX; CEREBELLUM; COMPARATIVE STUDY; IN VITRO STUDY; KINETICS; METABOLISM; SPRAGUE DAWLEY RAT; TIME;

ALLOSTERIC REGULATION; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BINDING, COMPETITIVE; BRAIN; CEREBELLUM; CEREBRAL CORTEX; CONVULSANTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; KINETICS; LIGANDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SULFUR RADIOISOTOPES; TIME FACTORS;

EID: 34247264412     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707186     Document Type: Article

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