Resistance to telomerase inhibition by human squamous cell carcinoma cell lines

International Journal of Oncology

Volumn 38, Issue 4, 2011, Pages 1175-1181

  Bojovic, Bojana ^a   Crowe, David L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Apoptosis; Microarray; Telomere restriction fragment length; Telomeric repeat amplification protocol

Indexed keywords

ANTINEOPLASTIC AGENT; BIBR 1532; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER RESISTANCE; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TELOMERE; UNINDEXED SEQUENCE;

AMINOBENZOIC ACIDS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES; GENES, DOMINANT; HUMANS; MUTANT PROTEINS; NAPHTHALENES; PHENOTYPE; RECOMBINANT PROTEINS; TELOMERASE;

EID: 79952347266     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.935     Document Type: Article

References (19)

1. Bailey SM, Cornforth MN, Kurimasa A, Chen DJ and Goodwin EH: Strand specific postreplicative processing of mammalian telomeres. Science 293: 2462-2465, 2001. (Pubitemid 32917329)
2. Wang RC, Smogorzewska A and de Lange T: Homologous recombination generates T loop sized deletions at human telomeres. Cell 119: 355-368, 2004. (Pubitemid 39423838)
3. Fitzgerald MS, Riha K, Gao F, Ren S, McKnight TD and Shippen DE: Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Proc Natl Acad Sci USA 96: 14813-14818, 1999.
4. Karlseder J, Smogorzewska A and de Lange T: Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449, 2002. (Pubitemid 34270257)
5. Harrington L, Zhou W, McPhail T, Oulton R, Yeung DSK, Mar V, Bass MB and Robinson MO: Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev 11: 3109-3115, 1997. (Pubitemid 27528051)
6. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S and Wright WE: Extension of lifespan by introduction of telomerase into normal human cells. Science 279: 349-352, 1998. (Pubitemid 28063364)
7. Zhang X, Mar V, Zhou W, Harrington L and Robinson MO: Telomere shortening and apoptosis in telomerase inhibited human tumor cells. Genes Dev 13: 2388-2399, 1999. (Pubitemid 29453610)
8. Damm K, Hemmann U, Garin-Chesa P, et al: A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J 20: 6958-6968, 2001. (Pubitemid 34062288)
9. Park JG: Effective inhibition of cancer cell growth by a novel tripartite transfection complex containing ribbon antisense molecules to hTR. Cancer Res Treat 36: 308-314, 2004.
10. Diala I, Murao S and Fujii M: Antisense inhibition of human telomerase by phosphorothioate oligonucleotide peptide conjugates. Nucleic Acids Symp Ser 52: 679-680, 2008.
11. Gryaznov SM: Oligonucleotide n3′-> p5′ phosphoramidates and thio-phosphoramidates as potential therapeutic agents. Chem Biodivers 7: 477-493, 2010.
12. Long S, Argyle DJ, Gault EA and Nasir L: Inhibition of telomerase in canine cancer cells following telomestatin treatment. Vet Comp Oncol 5: 99-107, 2007.
13. Chen Z, Zheng KW, Hao YH and Tan Z: Reduced or diminished stabilization of the telomere G quadruplex and inhibition of telomerase by small chemical ligands under molecular crowding conditions. J Am Chem Soc 131: 10430-10438, 2009.
14. Wang W, Jin B, Li W, Xu CX, Cui FA, Liu B, Yan YF, Liu XX and Wang XL: Targeted antitumor effect induced by hTERT promoter mediated ODC antisense adenovirus. Mol Biol Rep 37: 3239-3247, 2010.
15. Liu XH, Liu HF, Chen J, Yang Y, Song BA, Bai LS, Liu JX, Zhu HL and Qi XB: Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents. Bioorg Med Chem Lett 20: 5705-5708, 2010.
16. Tokcaer-Keskin Z, Dikmen ZG, Ayaloglu-Butun F, Gultekin S, Gryaznov SM and Akcali KC: The effect of telomerase template antagonist GRN163L on bone marrow derived rat mesenchymal stem cells is reversible and associated with altered expression of cyclin D1, cdk4, and cdk6. Stem Cell Rev 6: 224-233, 2010.
17. Brennan SK, Wang Q, Tressler R, Harley C, Go N, Basset E, Huff CA, Jones RJ and Matsui W: Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length dependent and independent mechanisms. PLoS One 5: e12487, 2010.
18. Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW and Bachoo RM: The telomerase antagonist imetelstat efficiently targeted glioblastoma tumor initiating cells leading to decreased proliferation and tumor growth. Clin Cancer Res 16: 154-163, 2010.
19. Marian CO, Wright WE and Shay JW: The effects of telomerase inhibition on prostate tumor initiating cells. Int J Cancer 127: 321-331, 2010.