메뉴 건너뛰기




Volumn 119, Issue 3, 2011, Pages 371-376

Gene expression alterations in immune system pathways in the thymus after exposure to immunosuppressive Chemicals

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Cyclophosphamide; Dexamethasone; Diethylstilbestrol; T cell; Thymus; Toxicogenomics

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CD28 ANTIGEN; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DIETHYLSTILBESTROL; T LYMPHOCYTE RECEPTOR;

EID: 79952341104     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002358     Document Type: Article
Times cited : (39)

References (48)
  • 1
    • 0034618733 scopus 로고    scopus 로고
    • The immune system as a potential target for environmental estrogens (endocrine disrupters): A new emerging field
    • Ahmed SA. 2000. The immune system as a potential target for environmental estrogens (endocrine disrupters): a new emerging field. Toxicology 150:191-206.
    • (2000) Toxicology , vol.150 , pp. 191-206
    • Ahmed, S.A.1
  • 2
    • 77049090813 scopus 로고    scopus 로고
    • Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning
    • Auerbach SS, Shah RR, Mav D, Smith CS, Walker NJ, Vallant MK, et al. 2010. Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning. Toxicol Appl Pharmacol 243:300-314.
    • (2010) Toxicol Appl Pharmacol , vol.243 , pp. 300-314
    • Auerbach, S.S.1    Shah, R.R.2    Mav, D.3    Smith, C.S.4    Walker, N.J.5    Vallant, M.K.6
  • 3
    • 34250189127 scopus 로고    scopus 로고
    • Kruppel-like factor 2 controls T-cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor-1 transcription
    • Bai A, Hu H, Yeung M, Chen J. 2007. Kruppel-like factor 2 controls T-cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor-1 transcription. J Immunol 178:7632-7639.
    • (2007) J Immunol , vol.178 , pp. 7632-7639
    • Bai, A.1    Hu, H.2    Yeung, M.3    Chen, J.4
  • 7
    • 21244440594 scopus 로고    scopus 로고
    • Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells
    • Camacho I, Singh N, Hegde V, Nagarkatti M, Nagarkatti P. 2005. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. J Immunol 175:90-103.
    • (2005) J Immunol , vol.175 , pp. 90-103
    • Camacho, I.1    Singh, N.2    Hegde, V.3    Nagarkatti, M.4    Nagarkatti, P.5
  • 8
    • 76749098737 scopus 로고    scopus 로고
    • Overview of the immune response
    • Chaplin DD. 2010. Overview of the immune response. J Allergy Clin Immunol 125:S3-S23.
    • (2010) J Allergy Clin Immunol , vol.125
    • Chaplin, D.D.1
  • 9
    • 77950357495 scopus 로고    scopus 로고
    • Use of transcriptomics in understanding mechanisms of drug-induced toxicity
    • Cui Y, Paules R. 2010. Use of transcriptomics in understanding mechanisms of drug-induced toxicity. Pharmacogenomics 11:573-585.
    • (2010) Pharmacogenomics , vol.11 , pp. 573-585
    • Cui, Y.1    Paules, R.2
  • 10
    • 0020259493 scopus 로고
    • Procedures available to examine the immunotoxicity of chemicals and drugs
    • Dean JH, Luster MI, Boorman GA, Lauer LD. 1982. Procedures available to examine the immunotoxicity of chemicals and drugs. Pharmacol Rev 34:137-148.
    • (1982) Pharmacol Rev , vol.34 , pp. 137-148
    • Dean, J.H.1    Luster, M.I.2    Boorman, G.A.3    Lauer, L.D.4
  • 11
    • 0004182315 scopus 로고
    • Dean JH, Luster MI, Munson AE, Amos H, eds., New York:Raven Press
    • Dean JH, Luster MI, Munson AE, Amos H, eds. 1985. Immunotoxicology and Immunopharmacology. New York:Raven Press.
    • (1985) Immunotoxicology and Immunopharmacology
  • 12
    • 37249094056 scopus 로고    scopus 로고
    • Human thymic dendritic cells: Regulators of T-cell development in health and HIV-1 infection
    • Evans VA, Cameron PU, Lewin SR. 2008. Human thymic dendritic cells: regulators of T-cell development in health and HIV-1 infection. Clin Immunol 126:1-12.
    • (2008) Clin Immunol , vol.126 , pp. 1-12
    • Evans, V.A.1    Cameron, P.U.2    Lewin, S.R.3
  • 13
    • 1542476894 scopus 로고    scopus 로고
    • Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity
    • Fisher MT, Nagarkatti M, Nagarkatti PS. 2004. Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity. Toxicol Sci 78:116-124.
    • (2004) Toxicol Sci , vol.78 , pp. 116-124
    • Fisher, M.T.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 14
    • 0034704363 scopus 로고    scopus 로고
    • DES action in the thymus: Inhibition of cell proliferation and genetic variation
    • Gould K, Shull J, Gorski J. 2000. DES action in the thymus: inhibition of cell proliferation and genetic variation. Mol Cell Endocrinol 170:31-39.
    • (2000) Mol Cell Endocrinol , vol.170 , pp. 31-39
    • Gould, K.1    Shull, J.2    Gorski, J.3
  • 16
    • 33847775657 scopus 로고    scopus 로고
    • Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations
    • Heinloth AN, Boorman GA, Foley JF, Flagler ND, Paules RS. 2007. Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations. Toxicol Pathol 35:276-300.
    • (2007) Toxicol Pathol , vol.35 , pp. 276-300
    • Heinloth, A.N.1    Boorman, G.A.2    Foley, J.F.3    Flagler, N.D.4    Paules, R.S.5
  • 18
    • 0032703994 scopus 로고    scopus 로고
    • Prenatal immunotoxicant exposure and postnatal autoimmune disease
    • Holladay SD. 1999. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environ Health Perspect 107:S687-S691.
    • (1999) Environ Health Perspect , vol.107
    • Holladay, S.D.1
  • 19
    • 0036147662 scopus 로고    scopus 로고
    • Recent advances in understanding the mechanisms of TCDD immunotoxicity
    • Kerkvliet NI. 2002. Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int Immunopharmacol 2:277-291.
    • (2002) Int Immunopharmacol , vol.2 , pp. 277-291
    • Kerkvliet, N.I.1
  • 20
    • 0029655335 scopus 로고    scopus 로고
    • The regulation and function of the CD4 coreceptor during T-lymphocyte development
    • Killeen N, Littman D. 1996. The regulation and function of the CD4 coreceptor during T-lymphocyte development. Curr Top Microbiol Immunol 205:89-106.
    • (1996) Curr Top Microbiol Immunol , vol.205 , pp. 89-106
    • Killeen, N.1    Littman, D.2
  • 21
    • 0029122893 scopus 로고
    • Intermediate steps in thymic positive selection. Generation of CD4-8+ T-cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3
    • Kydd R, Lundberg K, Vremec D, Harris A, Shortman K. 1995. Intermediate steps in thymic positive selection. Generation of CD4-8+ T-cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3. J Immunol 155:3806-3814.
    • (1995) J Immunol , vol.155 , pp. 3806-3814
    • Kydd, R.1    Lundberg, K.2    Vremec, D.3    Harris, A.4    Shortman, K.5
  • 22
    • 0034001020 scopus 로고    scopus 로고
    • Altered immune responses in apolipoprotein E-deficient mice
    • Laskowitz D, Lee D, Schmechel D, Staats H. 2000. Altered immune responses in apolipoprotein E-deficient mice. J Lipid Res 41:613-620.
    • (2000) J Lipid Res , vol.41 , pp. 613-620
    • Laskowitz, D.1    Lee, D.2    Schmechel, D.3    Staats, H.4
  • 23
    • 34547676512 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates functional differentiation of mouse bone marrow-derived dendritic cells: downregulation of RelB by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Lee JA, Hwang JA, Sung HN, Jeon CH, Gill BC, Youn HJ, et al. 2007. 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates functional differentiation of mouse bone marrow-derived dendritic cells: downregulation of RelB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett 173:31-40.
    • (2007) Toxicol Lett , vol.173 , pp. 31-40
    • Lee, J.A.1    Hwang, J.A.2    Sung, H.N.3    Jeon, C.H.4    Gill, B.C.5    Youn, H.J.6
  • 24
    • 33947637218 scopus 로고    scopus 로고
    • Glucorcorticoid signaling: A nongenomic mechanism for T-cell immunosuppression
    • Lowenberg M, Verhaar AP, van den Brink GR, Hommes DW. 2007. Glucorcorticoid signaling: a nongenomic mechanism for T-cell immunosuppression. Trends Mol Med 13:158-163.
    • (2007) Trends Mol Med , vol.13 , pp. 158-163
    • Lowenberg, M.1    Verhaar, A.P.2    van den Brink, G.R.3    Hommes, D.W.4
  • 26
    • 0019503984 scopus 로고
    • The effects of orthophenylphenol, tris(2,3-dichloropropyl) phosphate, and cyclophosphamide on the immune system and host susceptibility of mice following subchronic exposure
    • Luster MI, Dean JH, Boorman GA, Archer DL, Lauer L, Lawson LD, et al. 1981. The effects of orthophenylphenol, tris(2,3-dichloropropyl) phosphate, and cyclophosphamide on the immune system and host susceptibility of mice following subchronic exposure. Toxicol Appl Pharmacol 58:252-261.
    • (1981) Toxicol Appl Pharmacol , vol.58 , pp. 252-261
    • Luster, M.I.1    Dean, J.H.2    Boorman, G.A.3    Archer, D.L.4    Lauer, L.5    Lawson, L.D.6
  • 27
    • 0033624884 scopus 로고    scopus 로고
    • Regulatory roles for FcgammaRIII (CD16) and FcgammaRII (CD32) in the development of T- and B-lineage lymphoid cells
    • Lynch R. 2000. Regulatory roles for FcgammaRIII (CD16) and FcgammaRII (CD32) in the development of T- and B-lineage lymphoid cells. J Leukoc Biol 67:279-284.
    • (2000) J Leukoc Biol , vol.67 , pp. 279-284
    • Lynch, R.1
  • 28
    • 0037418599 scopus 로고    scopus 로고
    • Dexamethasone-induced thymocyte apoptosis requires glucocorticoid receptor nuclear translocation but not mitochondrial membrane potential transition
    • Marchetti MC, Di Marco B, Santini MC, Bartoli A, Delfino DV, Riccardi C. 2003. Dexamethasone-induced thymocyte apoptosis requires glucocorticoid receptor nuclear translocation but not mitochondrial membrane potential transition. Toxicol Lett 139:175-180.
    • (2003) Toxicol Lett , vol.139 , pp. 175-180
    • Marchetti, M.C.1    di Marco, B.2    Santini, M.C.3    Bartoli, A.4    Delfino, D.V.5    Riccardi, C.6
  • 29
    • 0028057579 scopus 로고
    • Generation of mature T-cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation
    • Marodon G, Rocha B. 1994. Generation of mature T-cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation. Eur J Immunol 24:196-204.
    • (1994) Eur J Immunol , vol.24 , pp. 196-204
    • Marodon, G.1    Rocha, B.2
  • 30
    • 0028984182 scopus 로고
    • IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide
    • Matthys P, Froyen G, Verdot L, Huang S, Sobis H, Van Damme J, et al. 1995. IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide. J Immunol 155(8):3823-3829.
    • (1995) J Immunol , vol.155 , Issue.8 , pp. 3823-3829
    • Matthys, P.1    Froyen, G.2    Verdot, L.3    Huang, S.4    Sobis, H.5    van Damme, J.6
  • 31
    • 0033998582 scopus 로고    scopus 로고
    • Differential effects of corticosteroids during different stages of dendritic cell maturation
    • Matyszak M, Citterio S, Rescigno M, Ricciardi-Castagnoli P. 2000. Differential effects of corticosteroids during different stages of dendritic cell maturation. Eur J Immunol 30:1233-1242.
    • (2000) Eur J Immunol , vol.30 , pp. 1233-1242
    • Matyszak, M.1    Citterio, S.2    Rescigno, M.3    Ricciardi-Castagnoli, P.4
  • 32
    • 37549046367 scopus 로고    scopus 로고
    • Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphcyte function
    • Pargmann D, Yücel R, Kosan C, Saba I, Klein-Hitpass L, Schimmer S, et al. 2007. Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphcyte function. Eur J Immunol 37:3551-3563.
    • (2007) Eur J Immunol , vol.37 , pp. 3551-3563
    • Pargmann, D.1    Yücel, R.2    Kosan, C.3    Saba, I.4    Klein-Hitpass, L.5    Schimmer, S.6
  • 33
    • 33845629799 scopus 로고    scopus 로고
    • Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals
    • Patterson RM, Germolec DR. 2006. Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals. Ann NY Acad Sci 1076:718-727.
    • (2006) Ann NY Acad Sci , vol.1076 , pp. 718-727
    • Patterson, R.M.1    Germolec, D.R.2
  • 34
    • 79952335939 scopus 로고    scopus 로고
    • Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals [Abstract 1750]
    • Patterson RM, Walker NJ, White KJ, Brown R, Musgrove D, Harrison S, et al. 2006. Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals [Abstract 1750]. Toxicologist 90(1):359.
    • (2006) Toxicologist , vol.90 , Issue.1 , pp. 359
    • Patterson, R.M.1    Walker, N.J.2    White, K.J.3    Brown, R.4    Musgrove, D.5    Harrison, S.6
  • 35
    • 33750362016 scopus 로고    scopus 로고
    • Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development
    • Rudd ML, Tua-Smith A, Straus DB. 2006. Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development. Mol Cell Biol 26:7892-7900.
    • (2006) Mol Cell Biol , vol.26 , pp. 7892-7900
    • Rudd, M.L.1    Tua-Smith, A.2    Straus, D.B.3
  • 36
    • 33846974070 scopus 로고    scopus 로고
    • Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma
    • Sasaki E, Yatabe Y, Hashimoto M, Yamashita Y, Hasegawa Y, Kojima H, et al. 2007. Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma. Pathol Int 57:53-59.
    • (2007) Pathol Int , vol.57 , pp. 53-59
    • Sasaki, E.1    Yatabe, Y.2    Hashimoto, M.3    Yamashita, Y.4    Hasegawa, Y.5    Kojima, H.6
  • 37
    • 0032489826 scopus 로고    scopus 로고
    • T-cell development in mice lacking all T-cell receptor zeta family members (zeta, eta, and FcepsilonRIgamma)
    • Shores E, Ono M, Kawabe T, Sommers C, Tran T, Lui K, et al. 1998. T-cell development in mice lacking all T-cell receptor zeta family members (zeta, eta, and FcepsilonRIgamma). J Exp Med 187:1093-1101.
    • (1998) J Exp Med , vol.187 , pp. 1093-1101
    • Shores, E.1    Ono, M.2    Kawabe, T.3    Sommers, C.4    Tran, T.5    Lui, K.6
  • 39
    • 0031569532 scopus 로고    scopus 로고
    • Calpain, an upstream regulator of thymocyte apoptosis
    • Squier MK, Cohen JJ. 1997. Calpain, an upstream regulator of thymocyte apoptosis. J Immunol 158:3690-3697.
    • (1997) J Immunol , vol.158 , pp. 3690-3697
    • Squier, M.K.1    Cohen, J.J.2
  • 41
    • 0022908423 scopus 로고
    • The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: A flow cytometric and immunohistochemical analysis
    • van Vliet E, Melis M, van Ewijk W. 1986. The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flow cytometric and immunohistochemical analysis. Cell Immunol 103:229-240.
    • (1986) Cell Immunol , vol.103 , pp. 229-240
    • van Vliet, E.1    Melis, M.2    van Ewijk, W.3
  • 42
    • 0037340785 scopus 로고    scopus 로고
    • Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antigen-presenting activity of dendritic cells
    • Vorderstrasse B, Dearstyne E, Kerkvliet N. 2003. Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antigen-presenting activity of dendritic cells. Toxicol Sci 72:103-112.
    • (2003) Toxicol Sci , vol.72 , pp. 103-112
    • Vorderstrasse, B.1    Dearstyne, E.2    Kerkvliet, N.3
  • 43
    • 0033012971 scopus 로고    scopus 로고
    • Relatively low-dose cyclophosphamide is likely to induce apoptotic cell death in rat thymus through Fas/Fas ligand pathway
    • Wang G, Cai L. 1999. Relatively low-dose cyclophosphamide is likely to induce apoptotic cell death in rat thymus through Fas/Fas ligand pathway. Mutat Res 427:125-133.
    • (1999) Mutat Res , vol.427 , pp. 125-133
    • Wang, G.1    Cai, L.2
  • 45
    • 0342470584 scopus 로고    scopus 로고
    • Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection
    • Williams O, Gil-Gómez G, Norton T, Kioussis D, Brady HJ. 2000. Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection. Eur J Immunol 30:709-713.
    • (2000) Eur J Immunol , vol.30 , pp. 709-713
    • Williams, O.1    Gil-Gómez, G.2    Norton, T.3    Kioussis, D.4    Brady, H.J.5
  • 46
    • 31144450253 scopus 로고    scopus 로고
    • Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor-1 and transcription factor-7 (T-cell factor-1) following antigen encounter in vitro and in vivo
    • Willinger T, Freeman T, Herbert M, Hasegawa H, McMichael A, Callan M. 2006. Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor-1 and transcription factor-7 (T-cell factor-1) following antigen encounter in vitro and in vivo. J Immunol 176:1439-1446.
    • (2006) J Immunol , vol.176 , pp. 1439-1446
    • Willinger, T.1    Freeman, T.2    Herbert, M.3    Hasegawa, H.4    McMichael, A.5    Callan, M.6
  • 47
    • 17644443312 scopus 로고    scopus 로고
    • The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T-cell progenitors and CD4/CD8 lineage decision in the thymus
    • Yucel R, Karsunky H, Klein-Hitpass L, Moroy T. 2003. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T-cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med 197:831-844.
    • (2003) J Exp Med , vol.197 , pp. 831-844
    • Yucel, R.1    Karsunky, H.2    Klein-Hitpass, L.3    Moroy, T.4
  • 48
    • 0034254290 scopus 로고    scopus 로고
    • Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism
    • Zhou Z, Gordon SA, Kim YM, Hoffman RA, Chen Y, Zhang XR, et al. 2000. Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism. J Immunol 165:1252-1258.
    • (2000) J Immunol , vol.165 , pp. 1252-1258
    • Zhou, Z.1    Gordon, S.A.2    Kim, Y.M.3    Hoffman, R.A.4    Chen, Y.5    Zhang, X.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.