2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates functional differentiation of mouse bone marrow-derived dendritic cells. Downregulation of RelB by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Toxicology Letters

Volumn 173, Issue 1, 2007, Pages 31-40

  Lee, Jin Ah ^a   Hwang, Ju Ae ^a   Sung, Ha Na ^a   Jeon, Chang Hwan ^a   Gill, Byoung Chul ^a   Youn, Hyun Joo ^b   Park, Joo Hung ^a  

^a Changwon National University   (South Korea)

^b Inje University   (South Korea)

Author keywords

Benzo(a)pyrene; Bone marrow derived dendritic cell; GM CSF; IL 4; RelB; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CD86 ANTIGEN; DNA; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RNA; TRANSCRIPTION FACTOR RELB;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; BONE MARROW; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD11C; ANTIGENS, CD86; BENZOFLAVONES; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DOWN-REGULATION; ENVIRONMENTAL POLLUTANTS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTOR RELB;

EID: 34547676512     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2007.06.012     Document Type: Article

References (42)

1. Agger R., Petersen M.S., Toldbod H.E., Holtz S., Dagnaes-Hansen F., Johnsen B.W., Bolund L., and Hokland M. Characterization of murine dendritic cells derived from adherent blood mononuclear cells in vitro. Scand. J. Immunol. 52 (2000) 138-147
2. Allan L.L., Schlezinger J.J., Shansab M., and Sherr D.H. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochem. Biophys. Res. Commum. 342 (2006) 227-235
3. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
4. Burbach K.M., Poland A., and Bradfield C.A. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 8185-8189
5. Camacho I.A., Hassuneh M.R., Nagarkatti M., and Nagarkatti P.S. Enhanced activation-induced cell death as a mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity in peripheral T-cells. Toxicology 13 (2001) 51-63
6. Cejas P.J., Carlson L.M., Kolonias D., Zhang J., Lindner I., Billadeau D.D., Boise L.H., and Lee K.P. Regulation of RelB expression during the initiation of dendritic cell differentiation. Mol. Cell Biol. 25 (2005) 7900-7916
7. Cho H.J., Hahn E.J., Hwang J.A., Hong M.S., Kim S.K., Pak H.R., and Park J.H. Enhanced expression of plasma glutathione peroxidase in the thymus of mice treated with TCDD and its implication for TCDD-induced thymic atrophy. Mol. Cells 21 (2006) 276-283
8. Ciolino H.P., and Yeh G.C. Inhibition of arylhydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol. Pharmacol. 56 (1999) 760-767
9. Dertinger S.D., Nazarenko D.A., Silverstone A.E., and Gasiewicz T.A. Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. Carcinogenesis 22 (2001) 171-177
10. Doherty P., Williams G., and Williams E.J. CAMs and axonal growth: a critical evaluation of the role of calcium and the MAPK cascade. Mol. Cell Neurosci. 16 (2000) 283-295
11. Emma M., Ohe N., Suzuki M., Mimura J., Sogawa K., Ikawa S., and Fujii-Kuriyama Y. Dioxin binding activities of polymorphic forms of mouse and human aryl hydrocarbon receptors. J. Biol. Chem. 269 (1994) 27337-27343
12. Favreau L.V., and Pickett C.B. Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants. J. Biol. Chem. 266 (1991) 4556-4561
13. Huff J., Lucier G., and Tritscher A. Carcinogenicity of TCDD: experimental, mechanistic, and epidemiologic evidence. Annu. Rev. Pharmacol. Toxicol. 34 (1994) 343-372
14. Hwang J.A., Lee J.A., Cheong S.W., Youn H.J., and Park J.H. Benzo(a)pyrene inhibits growth and functional differentiation of mouse bone marrow-derived dendritic cells. Downregulation of RelB and eIF3 p170 by benzo(a)pyrene. Toxicol. Lett. 169 (2007) 82-90
15. Inaba K., Inaba M., Deguchi M., Hagi K., Yasumizu R., Ikehara S., Muramatsu S., and Steinman R.M. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 3038-3042
16. Kerkvliet N.L., and Burleson G.R. Immunotoxicity of TCDD and related halogenated aromatic hydrocarbons. In: Dean J.H., Luster M.I., Munson A.E., and Kimber I. (Eds). Immonotoxicology and Immunopharmacology (1994), Raven Press, New York 97-121
17. Laupeze B., Amiot L., Sparfel L., Le Ferrec E., Fauchet R., and Fardel O. Polycyclic aromatic hydrocarbons affect functional differentiation and maturation of human mocyte-derived dendritic cells. J. Immunol. 168 (2002) 2652-2658
18. Lecureur V., Le Ferrec E., N'diaye M., Le Vee M., Gardyn C., Gilot D., and Fardel O. ERK-dependent induction of TNF-α expression by the environmental contaminant benzo(a)pyrene in primary human macrophages. FEBS Lett. 579 (2005) 1904-1910
19. Legare M.E., Hanneman W.H., Barhoumi R., and Tiffany-Castiglioni E. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in primary rat astroglia: identification of biochemical and cellular targets. Neurotoxicology 18 (1997) 515-524
20. Lutz M.B., and Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?. Trends Immunol. 23 (2002) 445-449
21. Lutz M.B., Kukutsch N., Ogilvie A.L.J., Rossner S., Koch F., Romani N., and Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223 (1999) 77-92
22. Lutz M.B., Kukutsch N.A., Enges M., Robner S., and Schuler G. Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T-cell anergy in vitro. Eur. J. Immunol. 30 (2000) 1048-1052
23. Oikawa K., Ohbayashi T., Mimura J., Iwata R., Kameta A., Evine K., Iwaya K., Fujii-Kuriyama Y., Kuroda M., and Mukai K. Dioxin suppresses the checkpoint protein, MAD2, by an aryl hydrocarbon receptor-independent pathway. Cancer Res. 61 (2001) 5707-5709
24. Park J.H., Hahn E.J., Kong J.H., Cho H.J., Yoon C.S., Cheong S.W., Oh G.S., and Yoon H.J. TCDD-induced apoptosis in EL-4 cells deficient of the aryl hydrocarbon receptor and downregulation of IGFBP-6 prevented the apoptotic cell death. Toxicol. Lett. 145 (2003) 55-68
25. Platzer B., Jorgl A., Taschner S., Hocher B., and Strobl H. RelB regulates human dendritic cell subset development by promoting monocyte intermediates. Blood 104 (2004) 3655-3663
26. Poland A., and Knutson J.C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22 (1982) 517-554
27. Prell R.A., and Kerkvliet N.I. Involvement of altered B7 expression in dioxin immunotoxicity: B7 transfection restores the CTL but not the autoantibody response to the P815 mastocytoma. J. Immunol. 158 (1997) 2695-2703
28. Puga A., Hoffer A., Zhou S., Bohm J.M., Leikauf G.D., and Shertzer H.G. Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin. Biochem. Pharmacol. 1997 (1997) 1287-1296
29. Ruby C.E., Leid M., and Kerkvliet N.I. 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-α and anti-CD40-induced activation of NF-κB/Rel in dendritic cells: p50 homodimer activation is not affected. Mol. Pharmacol. 62 (2002) 722-728
30. Rushmore T.H., and Pickett C.B. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene: characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. J. Biol. Chem. 265 (1990) 14648-14653
31. Schmidt J.V., and Bradfield C.A. Ah receptor signaling pathways. Annu. Rev. Cell Dev. Biol. 12 (1996) 55-89
32. Schreurs M.W.J., Eggert A.A.O., de Boer A.J., Figdor C.G., and Adema G.J. Generation and functional characterization of mouse monocyte-derived dendritic cells. Eur. J. Immunol. 29 (1999) 2835-2841
33. Shepherd D.M., Dearstyne E.A., and Kerkvliet N.I. The effects of TCDD on the activation of ovalbumin (OVA)-specific DO11.10 transgenic CD4(+) T-cells in adoptively transferred mice. Toxicol. Sci. 56 (2000) 340-350
34. Swanson H.I., and Bradfield C.A. The AH-receptor: genetics, structure and function. Pharmacogenetics 3 (1993) 213-230
35. Sweeney M.H., and Mocarelli P. Human health effects after exposure to 2,3,7,8-TCDD. Food Addit. Contam. 17 (2000) 303-316
36. Tan Z., Chang X., Puga A., and Xia Y. Activation of mitogen-activated kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AhR) function. Biochem. Pharmacol. 64 (2002) 771-780
37. Tritscher A.M., Goldstein J.A., Portier C.J., McCoy Z., Clark G.C., and Lucier G.W. Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantitation and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res. 52 (1992) 3436-3442
38. Vogel C., Boerboom A.M., Baechle C., El-Bahay C., Kahl R., Degen G.H., and Abel J. Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway. Carcinogenesis 21 (2000) 2267-2274
39. Vorderstrasse B.A., and Kerkvliet N.I. 2,3,7,8-Tetrachlorodibenzo-p-dioxin affects the number and function of murine splenic dendritic cells and their expression of accessory molecules. Toxicol. Appl. Pharmacol. 171 (2001) 117-125
40. Vorderstrasse B.A., Dearstyne E.A., and Kerkvliet N.I. Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antigen-presenting activity of dendritic cells. Toxicol. Sci. 72 (2003) 103-112
41. Vremec D., and Shortman K. Dendritic cell subtypes in mouse lymphoid organs. Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 159 (1997) 565-573
42. Wu L., D'Amico A., Winkel K.D., Suter M., Lo D., and Shortman K. RelB is essential for the development of myeloid-related CD8 alpha-dendritic cells but not of lymphoid-related CD8 + dendritic cells. Immunity 9 (1998) 839-847