Two major medicinal honeys have different mechanisms of bactericidal activity

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Kwakman, Paulus H S ^a   te Velde, Anje A ^a   de Boer, Leonie ^a   Vandenbroucke Grauls, Christina M J E ^a,b   Zaat, Sebastian A J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BEE DEFENSIN 1; DEFENSIN; HYDROGEN PEROXIDE; METHYLGLYOXAL; NATURAL PRODUCT; REVAMIL; UMF; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ARTICLE; BACILLUS SUBTILIS; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DILUTION; DRUG DETERMINATION; DRUG MECHANISM; ESCHERICHIA COLI; FOOD PRESERVATION; HONEY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PSEUDOMONAS AERUGINOSA; BACTERIUM; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; TIME;

APOIDEA; BACILLUS SUBTILIS; ESCHERICHIA COLI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; BACTERIA; DEFENSINS; HONEY; HYDROGEN PEROXIDE; MICROBIAL SENSITIVITY TESTS; PYRUVALDEHYDE; TIME FACTORS;

EID: 79952330749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017709     Document Type: Article

References (38)

1. Khanna T, Friendship R, Dewey C, Weese JS, (2008) Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers. Vet Microbiol 128: 298-303.
2. McEwen SA, Fedorka-Cray PJ, (2002) Antimicrobial use and resistance in animals. Clin Infect Dis 34 (Suppl 3): S93-S106.
3. Carattoli A, (2008) Animal reservoirs for extended spectrum beta-lactamase producers. Clin Microbiol Infect 14 (Suppl 1): 117-123.
4. Walsh C, (2003) Antibiotics: Actions, Origins, Resistance. Washington DC American Society for Microbiology (ASM) Press.
5. Fischbach MA, Walsh CT, (2009) Antibiotics for Emerging Pathogens. Science 325: 1089-1093.
6. Majno G, (1975) Man and wound in the ancient world. Massachusetts Harvard University Press Cambridge.
7. Zumla A, Lulat A, (1989) Honey-a remedy rediscovered. J R Soc Med 82: 384-385.
8. Cooper RA, Molan PC, Harding KG, (2002) The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds. J Appl Microbiol 93: 857-863.
9. Kwakman PHS, Van den Akker JPC, Guclu A, Aslami H, Binnekade JM, et al. (2008) Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization. Clin Infect Dis 46: 1677-1682.
10. Mundo MA, Padilla-Zakour OI, Worobo RW, (2004) Growth inhibition of foodborne pathogens and food spoilage organisms by select raw honeys. International Journal of Food Microbiology 97: 1-8.
11. Taormina PJ, Niemira BA, Beuchat LR, (2001) Inhibitory activity of honey against foodborne pathogens as influenced by the presence of hydrogen peroxide and level of antioxidant power. International Journal of Food Microbiology 69: 217-225.
12. Efem SEE, (1988) Clinical Observations on the Wound-Healing Properties of Honey. British Journal of Surgery 75: 679-681.
13. Allen KL, Molan PC, Reid GM, (1991) A survey of the antibacterial activity of some New Zealand honeys. J Pharm Pharmacol 43: 817-822.
14. Kwakman PHS, Te Velde AA, de Boer L, Speijer D, Vandenbroucke-Grauls CMJE, et al. (2010) How honey kills bacteria. FASEB J 24: 2576-2582.
15. Adams CJ, Boult CH, Deadman BJ, Farr JM, Grainger MN, et al. (2008) Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey. Carbohydr Res 343: 651-659.
16. Mavric E, Wittmann S, Barth G, Henle T, (2008) Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res 52: 483-489.
17. Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, et al. (1989) Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest 84: 553-561.
18. White JW Jr, Subers MH, (1963) Studies on honey inhibine. 2. A chemical assay. Journal of Apicultural Research 2: 93-100.
19. Racker E, (1951) The mechanism of action of glyoxalase. J Biol Chem 190: 685-696.
20. Harwig SS, Chen NP, Park AS, Lehrer RI, (1993) Purification of cysteine-rich bioactive peptides from leukocytes by continuous acid-urea-polyacrylamide gel electrophoresis. Anal Biochem 208: 382-386.
21. Bang LM, Buntting C, Molan P, (2003) The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Altern Complement Med 9: 267-273.
22. Bogdanov S, (1997) Nature and origin of the antibacterial substances in honey. Food Science and Technology-Lebensmittel-Wissenschaft & Technologie 30: 748-753.
23. Weston RJ, Brocklebank LK, Lu YR, (2000) Identification and quantitative levels of antibacterial components of some New Zealand honeys. Food Chemistry 70: 427-435.
24. Russell KM, Molan PC, Wilkins AL, Holland PT, (1990) Identification of Some Antibacterial Constituents of New-Zealand Manuka Honey. Journal of Agricultural and Food Chemistry 38: 10-13.
25. Weston RJ, Mitchell KR, Allen KL, (1999) Antibacterial phenolic components of New Zealand manuka honey. Food Chemistry 64: 295-301.
26. Molan PC, (1992) The Antibacterial Activity of Honey. 2. Variation in the Potency of the Antibacterial Activity. Bee World 73: 59-76.
27. White JW Jr, Subers MH, (1964) Studies on honey inhibine. 3. Effect of heat. Journal of Apicultural Research 3: 45-50.
28. White JW Jr, Subers MH, (1964) Studies on honey inhibine. 4. Destruction of the peroxide accumulation system by light. J Food Sci 29: 819-828.
29. Schepartz AI, (1966) Honey catalase: occurance and some kinetic properties. J Apic Res 5: 167-176.
30. White JW Jr, Subers MH, Schepartz AI, (1963) The identification of inhibine, the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucose oxidase system. Biochim Biophys Acta 73: 57-70.
31. Lensky Y, Rakover Y, (1983) Separate Protein Body Compartments of the Worker Honeybee (Apis-Mellifera L). Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology 75: 607-615.
32. Knecht D, Kaatz HH, (1990) Patterns of Larval Food-Production by Hypopharyngeal Glands in Adult Worker Honey-Bees. Apidologie 21: 457-468.
33. Bachanova K, Klaudiny J, Kopernicky J, Simuth J, (2002) Identification of honeybee peptide active against Paenibacillus larvae larvae through bacterial growth-inhibition assay on polyacrylamide gel. Apidologie 33: 259-269.
34. Weigel KU, Opitz T, Henle T, (2004) Studies on the occurrence and formation of 1,2-dicarbonyls in honey. European Food Research and Technology 218: 147-151.
35. Adams CJ, Manley-Harris M, Molan PC, (2009) The origin of methylglyoxal in New Zealand manuka (Leptospermum scoparium) honey. Carbohydr Res 344: 1050-1053.
36. Kalapos MP, (2008) The tandem of free radicals and methylglyoxal. Chem Biol Interact 171: 251-271.
37. Majtan J, (2010) Methylglyoxal- a Potential Risk Factor of Manuka Honey in Healing of Diabetic Ulcers. eCAM doi:10.1093/ecam/neq013.
38. Krushna NSA, Kowsalya A, Radha S, Narayanan RB, (2007) Honey as a natural preservative of milk. Indian Journal of Experimental Biology 45: 459-464.