Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma

European Journal of Endocrinology

Volumn 151, Issue 2, 2004, Pages 251-257

  Ciarmela, Pasquapina ^a   Florio, Pasquale ^a   Siguroardóttir, Matthildur ^a   Toti, Paolo ^a   Maguer Satta, Veronique ^b   Rimokh, Ruth ^b   Altomare, Aldo ^a   Tosi, Piero ^a   Petraglia, Felice ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b CENTRE LÉON BÉRARD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; FOLLISTATIN; FOLLISTATIN RELATED PROTEIN; LIGAND; MESSENGER RNA;

ADULT; AGED; ARTICLE; BLOOD VESSEL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; FEMALE; GENE EXPRESSION; GROWTH; HORMONE RELEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; MENOPAUSE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STROMA;

ADENOCARCINOMA; AGED; CELL NUCLEUS; CYTOPLASM; ENDOMETRIAL NEOPLASMS; FEMALE; FOLLISTATIN; FOLLISTATIN-RELATED PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; POSTMENOPAUSE; RNA, MESSENGER;

EID: 4444225620     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1510251     Document Type: Article

References (31)

1. Vale W, Rivier C, Hsueh A, Campen C, Meunier H, Bicsak T, Vaughan J, Corrigan A, Bardin W, Sawchenko P et al. Chemical and biological characterization of the inhibin family of protein hormones. Recent Progress in Hormone Research 1988 44 1-34.
2. Luisi S, Florio P, Reis FM & Petraglia F. Expression and secretion of activin A: possible physiological and clinical implications. European Journal of Endocrinology 2001 145 225-236.
3. Wankell M, Kaesler S, Zhang YQ, Florence C, Werner S & Duan R. The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair. Journal of Endocrinology 2001 171 385-395.
4. Ling N, Ying SY, Ueno N, Esch F, Denoroy L & Guillemin R. Isolation and partial characterization of a Mr 32 000 protein with inhibin activity from porcine follicular fluid. PNAS 1985 82 7217-7221.
5. Robertson DM, Klein R, de Vos FL, McLachlan RI, Wettenhall RE, Hearn MT, Burger HG & de Kretser DM. The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin. Biochemical and Biophysical Research Communications 1987 149 744-749.
6. Ueno N, Ling N, Ying SY, Esch F, Shimasaki S & Guillemin R. Isolation and partial characterization of follistatin: a single-chain Mr 35 000 monomeric protein that inhibits the release of follicle-stimulating hormone. PNAS 1987 84 8282-8286.
7. Nakamura T, Takio K, Eto Y, Shibai H, Titani K & Sugino H. Activin-binding protein from rat ovary is follistatin. Science 1990 247 836-838.
8. Kogawa K, Nakamura T, Sugino K, Takio K, Titani K & Sugino H. Activin-binding protein is present in pituitary. Endocrinology 1991 128 1434-1440.
9. de Winter JP, ten Dijke P, de Vries CJ, van Achterberg TA, Sugino H, de Waele P, Huylebroeck D, Verschueren K & van den Eijnden-van Raaij AJ. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors. Molecular and Cellular Endocrinology 1996 116 105-114.
10. Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP & Rimokh R. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. Oncogene 1998 16 2949-2954.
11. Tsuchida K, Arai KY, Kuramoto Y, Yamakawa N, Hasegawa Y & Sugino H. Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. Journal of Biological Chemistry 2000 275 40788-40796.
12. Sidis Y, Schneyer AL, Sluss PM, Johnson LN, & Keutmann HT. Follistatin: essential role for the N-terminal domain in activin binding and neutralization. Journal of Biological Chemistry 2001 276 17718-17726.
13. Tortoriello DV, Sidis Y, Holtzman DA, Holmes WE & Schneyer AL. Human follistatin-related protein: a structural homologue of follistatin with nuclear localization. Endocrinology 2001 142 3426-3434.
14. Maguer-Satta V, Bartholin L, Jeanpierre S, Gadoux M, Bertrand S, Martel S, Magaud JP & Rimokh R. Expression of FLRG, a novel activin A ligand, is regulated by TGF-beta and during hematopoiesis. Experimental Hematology 2001 29 301-308.
15. Petraglia F, Florio P, Luisi S, Gallo R, Gadducci A, Vigano P, Di Blasio AM, Genazzani AR & Vale W. Expression and secretion of inhibin and activin in normal and neoplastic uterine tissues. High levels of serum activin A in women with endometrial and cervical carcinoma. Journal of Clinical Endocrinology and Metabolism 1998 83 1194-1200.
16. Florio P, Luisi S, Vigano P, Busacca M, Fadalti M, Genazzani AR & Petraglia F. Healthy women and patients with endometriosis show high concentrations of inhibin A, inhibin B, and activin A in peritoneal fluid throughout the menstrual cycle. Human Reproduction 1998 13 2606-2611.
17. Leung PH, Salamonsen LA & Findlay JK. Immunolocalization of inhibin and activin subunits in human endometrium across the menstrual cycle. Human Reproduction 1998 13 3469-3477.
18. Jones RL, Salamonsen LA, Critchley HO, Rogers PA, Affandi B & Findlay JK. Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregnancy and in women using progestin-only contraception. Molecular Human Reproduction 2000 6 1107-1117.
19. Reis FM, Di Blasio AM, Florio P, Ambrosini G, Di Loreto C & Petraglia F. Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis. Fertility and Sterility 2001 75 367-373.
20. Otani T, Minami S, Kokawa K, Shikone T, Yamoto M & Nakano R. Immunohistochemical localization of activin A in human endometrial tissues during the menstrual cycle and in early pregnancy. Obstetrics and Gynecology 1998 91 685-692.
21. Otani T, Minami S, Yamoto M & Umesaki N. Production of activin A in hyperplasia and adenocarcinoma of the human endometrium. Gynecologic Oncology 2001 83 31-38.
22. Florio P, Severi FM, Luisi S, Ciarmela P, Calonaci G, Cobellis L & Petraglia F. Endometrial expression and secretion of activin A, but not follistatin, increase in the secretory phase of the menstrual cycle. Journal of the Society for Gynecologic Investigation 2003 10 237-243.
23. Florio P, Ciarmela P, Toti P, Maguer-Satta V, Rimokh R, Buonocore G, Rossi M & Petraglia F. Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide. Molecular and Cellular Endocrinology 2004 218 129-135.
24. Vigano P, Somigliana E, Mangioni S, Vignali M, Vignali M & Di Blasio AM. Expression of interleukin-10 and its receptor is upregulated in early pregnant versus cycling human endometrium. Journal of Clinical Endocrinology and Metabolism 2002 87 5730-5736.
25. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Research 1997 25 3389-3402.
26. Bilezikjian LM, Corrigan AZ, Vaughan JM & Vale WM. Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells. Endocrinology 1993 133 2554-2560.
27. Blauer M, Husgafvel S, Syvala H, Tuohimaa P & Ylikomi T. Identification of a nuclear localization signal in activin/inhibin betaA subunit; intranuclear betaA in rat spermatogenic cells. Biology of Reproduction 1999 60 588-593.
28. Kozian DH, Ziche M & Augustin HG. The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis. Laboratory Investigations 1997 76 267-276.
29. McCarthy SA & Bicknell R. Inhibition of vascular endothelial cell growth by activin-A. Journal of Biological Chemistry 1993 268 23066-23071.
30. Di Simone N, Schneyer AL, Caliandro D, Castellani R & Caruso A. Regulation of endometrial adenocarcinoma cell proliferation by activin-A and its modulation by 17beta-estradiol. Molecular and Cellular Endocrinology 2002 192 187-195.
31. Bartholin L, Maguer-Satta V, Hayette S, Martel S, Gadoux M, Corbo L, Magaud JP & Rimokh R. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. Oncogene 2002 21 2227-2235.