Tumor angiogenic marker expression levels during tumor growth: Longitudinal assessment with molecularly targeted microbubbles and US imaging

Radiology

Volumn 258, Issue 3, 2011, Pages 804-811

  Deshpande, Nirupama ^a   Ren, Ying ^a,b   Foygel, Kira ^a   Rosenberg, Jarrett ^a   Willmann, Jürgen K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGLIN; VASCULOTROPIN RECEPTOR 2; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER STAGING; CELL ADHESION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; ECHOGRAPHY; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; IN VIVO STUDY; MICROBUBBLE; MOUSE; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR STRESS; TUMOR XENOGRAFT;

ANIMALS; CONTRAST MEDIA; FEMALE; FLOW CYTOMETRY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTEGRINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICROBUBBLES; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; PANCREATIC NEOPLASMS; STATISTICS, NONPARAMETRIC; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 79952294928     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.10101079     Document Type: Article

References (27)

1. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3(6):401-410. (Pubitemid 37328844)
2. Palmowski M, Huppert J, Ladewig G, et al. Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects. Mol Cancer Ther 2008;7(1):101-109.
3. Hodivala-Dilke K. alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment. Curr Opin Cell Biol 2008;20(5):514-519.
4. ten Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 2008;11(1):79-89.
5. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004;25(4):581-611. (Pubitemid 39099316)
6. Sledge GW Jr, Rugo HS, Burstein HJ. The role of angiogenesis inhibition in the treatment of breast cancer. Clin Adv Hematol Oncol 2006;4(10 suppl 21):1-10; quiz 11-12.
7. Khosravi Shahi P, Soria Lovelle A, Pérez Manga G. Tumoral angiogenesis and breast cancer. Clin Transl Oncol 2009;11(3):138-142.
8. Gómez-Raposo C, Mendiola M, Barriuso J, Casado E, Hardisson D, Redondo A. Angiogenesis and ovarian cancer. Clin Transl Oncol 2009;11(9):564-571.
9. Bednarek W, Mazurek M, Cwiklińska A, Barczyński B. Expression of selected angiogenesis markers and modulators in pre-, peri- and postmenopausal women with ovarian cancer [in Polish]. Ginekol Pol 2009;80(2):93-98.
10. Saif MW. Anti-angiogenesis therapy in pancreatic carcinoma. JOP 2006;7(2):163-173.
11. Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2(2):91-100. (Pubitemid 37328796)
12. van der Flier A, Sonnenberg A. Function and interactions of integrins. Cell Tissue Res 2001;305(3):285-298. (Pubitemid 34212122)
13. Fonsatti E, Altomonte M, Arslan P, Maio M. Endoglin (CD105): a target for anti-angiogenetic cancer therapy. Curr Drug Targets 2003;4(4):291-296. (Pubitemid 36443247)
14. Bernabeu C, Lopez-Novoa JM, Quintanilla M. The emerging role of TGF-beta superfamily coreceptors in cancer. Biochim Biophys Acta 2009;1792(10):954-973.
15. Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23(5):1011-1027. (Pubitemid 46202320)
16. Lindner JR. Microbubbles in medical imaging: current applications and future directions Nat Rev Drug Discov 2004;3(6):527-532.
17. Willmann JK, van Bruggen N, Dinkelborg LM, Gambhir SS. Molecular imaging in drug development. Nat Rev Drug Discov 2008;7(7):591-607. (Pubitemid 351927724)
18. Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JK. Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55). Radiology 2010;256(2):519-527.
19. Klibanov AL. Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. Bioconjug Chem 2005;16(1):9-17. (Pubitemid 40129671)
20. Willmann JK, Cheng Z, Davis C, et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology 2008;249(1):212-219.
21. Ellegala DB, Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 2003;108(3):336-341.
22. Rychak JJ, Graba J, Cheung AM, et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging 2007;6(5):289-296. (Pubitemid 350013534)
23. Willmann JK, Paulmurugan R, Chen K, et al. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology 2008;246(2):508-518.
24. Willmann JK, Lutz AM, Paulmurugan R, et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology 2008;248(3):936-944.
25. Willmann JK, Kimura RH, Deshpande N, Lutz AM, Cochran JR, Gambhir SS. Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides. J Nucl Med 2010;51(3):433-440.
26. Smeenk HG, Tran TC, Erdmann J, van Eijck CH, Jeekel J. Survival after surgical management of pancreatic adenocarcinoma: does curative and radical surgery truly exist? Langenbecks Arch Surg 2005;390(2):94-103.
27. Needles A, Mehi J, Bilan C, et al. Nonlinear molecular imaging with a linear array based micro-ultrasound system. Presented at the 2009 World Molecular Imaging Conference, Montreal, Canada, 2009.