An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 6, 2011, Pages 2563-2568

  Benfenati, Valentina ^a   Caprini, Marco ^b   Dovizio, Melania ^b   Mylonakou, Maria N ^c   Ferroni, Stefano ^b   Ottersen, Ole P ^c   Amiry Moghaddam, Mahmood ^c  

^a CNR   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Brain edema; Glia; Water channel

Indexed keywords

AQUAPORIN 1; AQUAPORIN 4; CALCIUM; SMALL INTERFERING RNA; VANILLOID RECEPTOR 4;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CELL MEMBRANE; CELL VOLUME; CONTROLLED STUDY; GENE SILENCING; HYPOOSMOTIC STRESS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMALS; AQUAPORIN 1; AQUAPORIN 4; ASTROCYTES; CALCIUM; CELL SIZE; CERCOPITHECUS AETHIOPS; COS CELLS; CRICETINAE; HUMANS; MICE; MICE, KNOCKOUT; OSMOTIC PRESSURE; SIGNAL TRANSDUCTION; TRPV CATION CHANNELS;

MUS;

EID: 79952292074     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1012867108     Document Type: Article

References (31)

1. Pasantes-Morales H, Lezama R-A, Ramos-Mandujano G, Tuz K-L (2006) Mechanisms of cell volume regulation in hypo-osmolality. Am J Med 119(7, Suppl 1)S4-S11.
2. Simard M, Nedergaard M (2004) The neurobiology of glia in the context of water and ion homeostasis. Neuroscience 129:877-896. (Pubitemid 39556241)
3. Amiry-Moghaddam M, Ottersen O-P (2003) The molecular basis of water transport in the brain. Nat Rev Neurosci 4:991-1001. (Pubitemid 37486675)
4. Verbalis J-G (2006) Control of brain volume during hypoosmolality and hyperosmolality. Adv Exp Med Biol 576:113-129, discussion 361-363.
5. Amiry-Moghaddam M, Frydenlund D-S, Ottersen O-P (2004) Anchoring of aquaporin-4 in brain: Molecular mechanisms and implications for the physiology and pathophysiology of water transport. Neuroscience 129:999-1010. (Pubitemid 39556251)
6. Kimelberg H-K (2005) Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy. Glia 50:389-397.
7. Benfenati V, et al. (2007) Functional down-regulation of volume-regulated anion channels in AQP4 knockdown cultured rat cortical astrocytes. J Neurochem 100:87-104. (Pubitemid 46085841)
8. Benfenati V, et al. (2007) Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes. Neuroscience 148:876-892. (Pubitemid 47419191)
9. Becker D, Blase C, Bereiter-Hahn J, Jendrach M (2005) TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 118:2435-2440. (Pubitemid 40873083)
10. Arniges M, Vázquez E, Fernández-Fernández J-M, Valverde M-A (2004) Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem 279:54062-54068. (Pubitemid 40053140)
11. Liu X, et al. (2006) A role for AQP5 in activation of TRPV4 by hypotonicity: Concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem 281:15485-15495. (Pubitemid 43855141)
12. Sidhaye V-K, et al. (2006) Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Proc Natl Acad Sci USA 103:4747-4752.
13. Pan Z, et al. (2008) Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells. Cell Calcium 44:374-385.
14. Liedtke W (2008) Molecular mechanisms of TRPV4-mediated neural signaling. Ann N Y Acad Sci 1144:42-52.
15. Mutai H, Heller S (2003) Vertebrate and invertebrate TRPV-like mechanoreceptors. Cell Calcium 33:471-478. (Pubitemid 36748669)
16. Liedtke W, et al. (2000) Vanilloid receptor-related osmotically activated channel (VROAC), a candidate vertebrate osmoreceptor. Cell 103:525-535.
17. Radany E-H, et al. (1992) Directed establishment of rat brain cell lines with the phenotypic characteristics of type 1 astrocytes. Proc Natl Acad Sci USA 89:6467-6471.
18. Mola M-G, Nicchia G-P, Svelto M, Spray D-C, Frigeri A (2009) Automated cell-based assay for screening of aquaporin inhibitors. Anal Chem 81:8219-8229.
19. Chvátal A, Anderová M, Kirchhoff F (2007) Three-dimensional confocal morphometry - a new approach for studying dynamic changes in cell morphology in brain slices. J Anat 210:671-683. (Pubitemid 46851002)
20. Mongin A-A, Cai Z, Kimelberg H-K (1999) Volume-dependent taurine release from cultured astrocytes requires permissive [Ca(2+)](i) and calmodulin. Am J Physiol 277:C823-C832. (Pubitemid 29525921)
21. O'Connor E-R, Kimelberg H-K (1993) Role of calcium in astrocyte volume regulation and in the release of ions and amino acids. J Neurosci 13:2638-2650.
22. Liedtke W (2006) Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli. J Endocrinol 191:515-523.
23. Becker D, Bereiter-Hahn J, Jendrach M (2009) Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation. Eur J Cell Biol 88:141-152.
24. Cohen D-M (2007) The transient receptor potential vanilloid-responsive 1 and 4 cation channels: Role in neuronal osmosensing and renal physiology. Curr Opin Nephrol Hypertens 16:451-458.
25. Liapi A, Wood J-N (2005) Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur J Neurosci 22:825-834. (Pubitemid 41243324)
26. Arniges M, Fernández-Fernández JM, Albrecht N, Schaefer M, Valverde MA (2006) Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem 281(3):1580-1586.
27. Cohen D-M (2006) Regulation of TRP channels by N-linked glycosylation. Semin Cell Dev Biol 17:630-637.
28. Zeynalov E, et al. (2008) The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edema. Crit Care Med 36:2634-2640.
29. Zelenin S, Gunnarson E, Alikina T, Bondar A, Aperia A (2000) Identification of a new form of AQP4 mRNA that is developmentally expressed in mouse brain. Pediatr Res 48:335-339. (Pubitemid 30637333)
30. Amiry-Moghaddam M, et al. (2004) Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J 18:542-544.
31. Benfenati V, Caprini M, Nobile M, Rapisarda C, Ferroni S (2006) Guanosine promotes the up-regulation of inward rectifier potassium current mediated by Kir4.1 in cultured rat cortical astrocytes. J Neurochem 98:430-445. (Pubitemid 44133148)