4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: Possible protection by NF-κB and ERK/MAPK

Toxicology and Applied Pharmacology

Volumn 208, Issue 1, 2005, Pages 46-56

  Chen, Zhi Hua ^a   Na, Hye Kyung ^a   Hurh, Yeon Jin ^a   Surh, Young Joon ^a  

^a Seoul National University   (South Korea)

Author keywords

4 OHE2; Apoptosis; ERK; MCF 10A cells; NF B; Oxidative DNA damage; ROS

Indexed keywords

4 HYDROXYESTRADIOL; 8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; CATECHOL ESTROGEN; CYTOCHROME P450 1B1; ESTRADIOL; ESTROGEN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TROLOX C;

APOPTOSIS; ARTICLE; BREAST CELL; BREAST EPITHELIUM; CELL DEATH; CELL DISRUPTION; CELL MEMBRANE POTENTIAL; CELL STRAIN MCF 7; CELL SURVIVAL; CYTOTOXICITY; DNA ADDUCT; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; BINDING SITES; CATTLE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHELATING AGENTS; CHROMANS; COPPER SULFATE; DEOXYGUANOSINE; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; ESTRADIOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUCIFERASES; MAMMARY GLANDS, HUMAN; MODELS, BIOLOGICAL; NF-KAPPA B; OXIDATIVE STRESS; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 24744454832     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.01.010     Document Type: Article

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