PTCH1 gene inactivation is not a Keratocystic odontogenic tumour exclusive alteration

Oral Oncology

Volumn 47, Issue 3, 2011, Pages 226-227

  Gomes, Carolina Cavaliéri ^a   Gomez, Ricardo Santiago ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL CELL NEVUS SYNDROME; CANCER SUSCEPTIBILITY; DISEASE ASSOCIATION; GENE; GENE FUNCTION; GENE INACTIVATION; HUMAN; KERATOCYSTIC ODONTOGENIC TUMOR; LETTER; MALIGNANT TRANSFORMATION; ODONTOGENIC TUMOR; PRIORITY JOURNAL; PTCH1 GENE;

BASAL CELL NEVUS SYNDROME; DIAGNOSIS, DIFFERENTIAL; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HEDGEHOG PROTEINS; HUMANS; LOSS OF HETEROZYGOSITY; MUTATION; ODONTOGENIC CYSTS; ODONTOGENIC TUMORS; RECEPTORS, CELL SURFACE;

EID: 79952283201     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2010.12.004     Document Type: Letter

References (17)

1. C. Thibert, M.A. Teillet, F. Lapointe, L. Mazelin, N.M. Le Douarin, and P. Mehlen Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog Science 301 5634 2003 843 846 (Pubitemid 36962627)
2. M. Evangelista, H. Tian, and F.J. de Sauvage The hedgehog signaling pathway in cancer Clin Cancer Res 12 20 Pt 1 2006 5924 5928 (Pubitemid 44703749)
3. C. Wang, U. Rüther, and B. Wang The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning Dev Biol 305 2 2007 460 469 (Pubitemid 46686613)
4. R. Toftgrd Hedgehog signalling in cancer Cell Mol Life Sci 57 12 2000 1720 1731
5. N.J. Lench, E.A. Telford, A.S. High, A.F. Markham, C. Wicking, and B.J. Wainwright Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome Hum Genet 100 5-6 1997 497 502 (Pubitemid 28072344)
6. D.C. Barreto, R.S. Gomez, A.E. Bale, W.L. Boson, and L. De Marco PTCH gene mutations in odontogenic keratocysts J Dent Res 79 6 2000 1418 1422 (Pubitemid 32489450)
7. World Health Organization Classification of Tumours. Ondontogenic tumours L. Barnes, J.W. Everson, P. Reichart, D. Sidransky, Pathology and genetics of head and neck tumours 2005 IARC Press Lyon 306 307
8. M.G. Diniz, E.R. Borges, A.L. Guimarães, P.R. Moreira, J.A. Brito, and M.V. Gomez PTCH1 isoforms in odontogenic keratocysts Oral Oncol 45 3 2009 291 295
9. S. Levanat, B. Pavelić, I. Crnić, S. Oresković, and S. Manojlović Involvement of PTCH gene in various noninflammatory cysts J Mol Med 78 3 2000 140 146 (Pubitemid 30337495)
10. B. Pavelić, S. Levanat, I. Crnić, P. Kobler, I. Anić, and S. Manojlović PTCH gene altered in dentigerous cysts J Oral Pathol Med 30 9 2001 569 576 (Pubitemid 32943816)
11. Z.S. Peacock, D. Cox, and B.L. Schmidt Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor Oral Oncol 46 5 2010 387 392
12. M.G. Diniz, C.F. Galvão, P.M. Serelle, C.C. Gomes, and R.S. Gomez Evidence of loss of heterozygosity of the PTCH gene in orthokeratinized odontogenic cyst J Oral Pathol Med 2011
13. D. Sidransky Is human patched the gatekeeper of common skin cancers Nat Genet 14 1 1996 7 8
14. N.P. Agaram, B. Collins, L. Barnes, D. Lomago, D. Aldeeb, and P. Swalsky Molecular analysis to demonstrate that odontogenic keratocyst are neoplastic Arch Pathol Lab Med 128 3 2004 313 317 (Pubitemid 38316077)
15. J. Henley, D.-J. Summerlin, C. Tomich, S. Zhang, and L. Cheng Molecular evidence supporting the neoplastic nature of odontogenic keratocyst: a laser capture microdissection study of 15 cases Histopathology 47 6 2005 582 586 (Pubitemid 41775180)
16. S. Pan, Q. Dong, L. Sun, and T. Li Mechanisms of inactivation of PTCH1 gene in nevoid basal cell carcinoma syndrome: Modification of the two-hit hypothesis Clin Can Res 16 2 2010 442 450
17. N. Demian, R.J. Harris, K. Abramovitch, Nagi Demian, J.W. Wilson, and N. Vigneswaran Malignant transformation of calcifying epithelial odontogenic tumor is associated iwht the loss of p53 transcriptional activity: a case report with review of the literature J Oral Maxillofac Surg 68 8 2010 1964 1973