Molecular Analysis to Demonstrate That Odontogenic Keratocysts Are Neoplastic

Archives of Pathology and Laboratory Medicine

Volumn 128, Issue 3, 2004, Pages 313-317

  Agaram, Narasimhan P ^a   Collins, Bobby M ^b   Barnes, Leon ^a   Lomago, Deren ^a   Aldeeb, Dalal ^a   Swalsky, Patricia ^a   Finkelstein, Sydney ^a   Hunt, Jennifer L ^a,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ADULT; AGED; ALLELISM; ARTICLE; BASAL CELL NEVUS SYNDROME; CANCER RECURRENCE; CLINICAL ARTICLE; CYST; FEMALE; GENE DELETION; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HETEROZYGOSITY LOSS; HUMAN; MALE; ODONTOGENIC KERATOCYST; ODONTOGENIC TUMOR; PTCH GENE; SCHOOL CHILD; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; CHILD; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; ODONTOGENIC CYSTS;

EID: 1542314269     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 1: clinical and early experimental evidence of aggressive behaviour. Oral Oncol. 2002;38:219-226.
2. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2: proliferation and genetic studies. Oral Oncol. 2002;38:323-331.
3. Blanas N, Freund B, Schwartz M, Furst IM. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:553-558.
4. Makowski GJ, McGuff S, Van Sickels JE. Squamous cell carcinoma in a maxillary odontogenic keratocyst. J Oral Maxillofac Surg. 2001;59:76-80.
5. Anand VK, Arrowood JP Jr, Krolls SO. Malignant potential of the odontogenic keratocyst. Otolaryngol Head Neck Surg. 1994;111:124-129.
6. Regezi JA. Odontogenic cysts, odontogenic tumors, fibroosseous, and giant cell lesions of the jaws. Mod Pathol. 2002;15:331-341.
7. Chow HT. Odontogenic keratocyst: a clinical experience in Singapore. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:573-577.
8. Barreto DC, Chimenos Kustner E. New considerations about the diagnosis of odontogenic keratocyst. Med Oral. 2001;6:350-357.
9. Barreto DC, Gomez RS, Bale AE, Boson WL, De Marco L. PTCH gene mutations in odontogenic keratocysts. J Dent Res. 2000;79:1418-1422.
10. Lench NJ, High AS, Markham AF, Hume WJ, Robinson PA. Investigation of chromosome 9q22.3-q31 DNA marker loss in odontogenic keratocysts. Eur J Cancer B Oral Oncol. 1996;32B:202-206.
11. Thiagalingam S, Foy RL, Cheng KH, Lee HJ, Thiagalingam A, Ponte JF. Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Curr Opin Oncol. 2002;14:65-72.
12. Philipsen HP. Om Keratocyster (kolesteatoma) I Kaeberbe. Tandlaegebladet. 1956.
13. Meara JG, Shah S, Li KK, Cunningham MJ. The odontogenic keratocyst: a 20-year clinicopathologic review. Laryngoscope. 1998;108:280-283.
14. Myoung H, Hong SP, Hong SD, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:328-333.
15. Cohen MM Jr. Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses. Int J Oral Maxillofac Surg. 1999;28:216-223.
16. Wicking C, Bale AE. Molecular basis of the nevoid basal cell carcinoma syndrome. Curr Opin Pediatr. 1997;9:630-635.
17. Kubota Y, Oka S, Nakagawa S, Shirasuna K. Interleukin-1alpha enhances type I collagen-induced activation of matrix metalloproteinase-2 in odontogenic keratocyst fibroblasts. J Dent Res. 2002;81:23-27.
18. Oliveira MD, Souza LB, Pinto LP, Freitas RA. Immunohistochemical study of components of the basement membrane in odontogenic cysts [in Portuguese]. Pesqui Odontol Bras. 2002;16:157-162.
19. de Paula AM, Carvalhais JN, Domingues MG, Barreto DC, Mesquita RA. Cell proliferation markers in the odontogenic keratocyst: effect of inflammation. J Oral Pathol Med. 2000;29:477-482.
20. Piattelli A, Fioroni M, Santinelli A, Rubini C. P53 protein expression in odontogenic cysts. J Endod. 2001;27:459-461.
21. Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971;68:820-823.