The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas

Oral Oncology

Volumn 47, Issue 3, 2011, Pages 211-216

  Tu, Hsi Feng ^a   Chang, Kuo Wei ^a,b   Chiang, Wei Fan ^a,c   Liu, Chung Ji ^a,d   Yu, En Hao ^a   Liu, Shou Tien ^a   Lin, Shu Chun ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Amplification; Carcinoma; Oral cavity; PAK1; PIK3CA

Indexed keywords

P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; CANCER CELL CULTURE; CANCER RISK; CARCINOGENICITY; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUTH CARCINOMA; ONCOGENE; ONCOGENE PAK1; ONCOGENE PIK3CA; PRIORITY JOURNAL; RECURRENT CANCER; TUMOR CELL;

CARCINOMA, SQUAMOUS CELL; GENE AMPLIFICATION; HUMANS; MOUTH NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; P21-ACTIVATED KINASES; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 79952281987     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2011.01.003     Document Type: Article

References (38)

1. S.Y. Liu, C.L. Lu, C.T. Chiou, C.Y. Yen, G.A. Liaw, and Y.C. Chen Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan Oral Oncol 46 4 2010 276 282
2. S.Y. Kao, Y.P. Chen, H.F. Tu, C.J. Liu, A.H. Yu, and C.H. Wu Nuclear STK15 expression is associated with aggressive behaviour of oral carcinoma cells in vivo and in vitro J Pathol 222 1 2010 99 109
3. S.C. Lin, C.J. Liu, S.Y. Ko, H.C. Chang, T.Y. Liu, and K.W. Chang Copy number amplification of 3q26-27 oncogenes in microdissected oral squamous cell carcinoma and oral brushed samples from areca chewers J Pathol 206 4 2005 417 422
4. Y.J. Chen, S.C. Lin, T. Kao, C.S. Chang, P.S. Hong, and T.M. Shieh Genome-wide profiling of oral squamous cell carcinoma J Pathol 204 3 2004 326 332 (Pubitemid 39430093)
5. K.E. Abou-Elhamd, and T.N. Habib The role of chromosomal aberrations in premalignant and malignant lesions in head and neck squamous cell carcinoma Eur Arch Otorhinolaryngol 265 2 2008 203 207 (Pubitemid 351178502)
6. H.B. Salvesen, S.L. Carter, M. Mannelqvist, A. Dutt, G. Getz, and I.M. Stefansson Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation Proc Natl Acad Sci USA 106 12 2009 4834 4839
7. B. Singh, P.G. Reddy, A. Goberdhan, C. Walsh, S. Dao, and I. Ngai P53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas Genes Dev 16 8 2002 984 993 (Pubitemid 34408547)
8. L. Zhao, and P.K. Vogt Class I PI3K in oncogenic cellular transformation Oncogene 27 41 2008 5486 5496
9. W.F. Chiang, P.S. Hung, S.Y. Liu, T.C. Yuan, K.W. Chang, and Y.P. Chen Increase of ZASC1 gene copy number in recurrent oral carcinoma Oral Dis 17 1 2010 53 59
10. C.L. Estilo, P. O-Charoenrat, I. Ngai, S.G. Patel, P.G. Reddy, and S. Dao The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue Clin Cancer Res 9 6 2003 2300 2306 (Pubitemid 36687656)
11. H.S. Liu, H.H. Lu, M.T. Lui, E.H. Yu, W. Shen, and Y.P. Chen Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers Oral Oncol 45 12 2009 1032 1036
12. B. Dummler, K. Ohshiro, R. Kumar, and J. Field Pak protein kinases and their role in cancer Cancer Metastasis Rev 28 1-2 2009 51 63
13. P. Schraml, G. Schwerdtfeger, F. Burkhalter, A. Raggi, D. Schmidt, and T. Ruffalo Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma Am J Pathol 163 3 2003 985 992 (Pubitemid 37040134)
14. R.A. Wang, A. Mazumdar, R.K. Vadlamudi, and R. Kumar P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium EMBO J 21 20 2002 5437 5447 (Pubitemid 35231023)
15. J. Bostner, M. Ahnstrom Waltersson, T. Fornander, L. Skoog, B. Nordenskjold, and O. Stal Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer Oncogene 26 49 2007 6997 7005 (Pubitemid 350014611)
16. L.A. Brown, S.E. Kalloger, M.A. Miller, M. Shih Ie, S.E. McKinney, and J.L. Santos Amplification of 11q13 in ovarian carcinoma Genes Chromosomes Cancer 47 6 2008 481 489 (Pubitemid 351657183)
17. S.C. Lin, S.Y. Lu, S.Y. Lee, C.Y. Lin, C.H. Chen, and K.W. Chang Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes Int J Cancer 116 4 2005 526 535
18. H.H. Lu, S.Y. Kao, T.Y. Liu, S.T. Liu, W.P. Huang, and K.W. Chang Areca nut extract induced oxidative stress and upregulated hypoxia inducing factor leading to autophagy in oral cancer cells Autophagy 6 6 2010 725 737
19. Y.H. Tseng, C.S. Chang, T.Y. Liu, S.Y. Kao, K.W. Chang, and S.C. Lin Areca nut extract treatment down-regulates involucrin in normal human oral keratinocyte through P13K/AKT activation Oral Oncol 43 7 2007 670 679
20. H.T. Wu, S.Y. Ko, J.H. Fong, K.W. Chang, T.Y. Liu, and S.Y. Kao Expression of phosphorylated Akt in oral carcinogenesis and its induction by nicotine and alkaline stimulation J Oral Pathol Med 38 2 2009 206 213
21. W.F. Chiang, S.Y. Liu, C.Y. Yen, C.N. Lin, Y.C. Chen, and S.C. Lin Association of epidermal growth factor receptor (EGFR) gene copy number amplification with neck lymph node metastasis in areca-associated oral carcinomas Oral Oncol 44 3 2008 270 276
22. P.S. Hung, S.Y. Kao, Y.H. Shih, S.H. Chiou, C.J. Liu, and K.W. Chang Insulin-like growth factor binding protein-5 (IGFBP-5) suppresses the tumourigenesis of head and neck squamous cell carcinoma J Pathol 214 3 2008 368 376
23. R. Redon, D. Muller, K. Caulee, K. Wanherdrick, J. Abecassis, and S. du Manoir A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains Cancer Res 61 10 2001 4122 4129 (Pubitemid 32720980)
24. A. Bardelli, and V.E. Velculescu Mutational analysis of gene families in human cancer Curr Opin Genet Dev 15 1 2005 5 12 (Pubitemid 40127625)
25. K. Stemke-Hale, A.M. Gonzalez-Angulo, A. Lluch, R.M. Neve, W.L. Kuo, and M. Davies An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer Cancer Res 68 15 2008 6084 6091
26. A. Sartore-Bianchi, M. Martini, F. Molinari, S. Veronese, M. Nichelatti, and S. Artale PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies Cancer Res 69 5 2009 1851 1857
27. G. Wu, E. Mambo, Z. Guo, S. Hu, X. Huang, and S.M. Gollin Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors J Clin Endocrinol Metab 90 8 2005 4688 4693 (Pubitemid 41159359)
28. G. Garcia-Rostan, A.M. Costa, I. Pereira-Castro, G. Salvatore, R. Hernandez, and M.J. Hermsem Mutation of the PIK3CA gene in anaplastic thyroid cancer Cancer Res 65 22 2005 10199 10207 (Pubitemid 41743711)
29. Y. Samuels, Z. Wang, A. Bardelli, N. Silliman, J. Ptak, and S. Szabo High frequency of mutations of the PIK3CA gene in human cancers Science 304 5670 2004 554 (Pubitemid 38541907)
30. K.C. Bruckman, F. Schonleben, W. Qiu, V.L. Woo, and G.H. Su Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110 5 2010 632 637
31. T.J. Lynch, D.W. Bell, R. Sordella, S. Gurubhagavatula, R.A. Okimoto, and B.W. Brannigan Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 21 2004 2129 2139 (Pubitemid 38637993)
32. C.H. Chung, K. Ely, L. McGavran, M. Varella-Garcia, J. Parker, and N. Parker Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas J Clin Oncol 24 25 2006 4170 4176 (Pubitemid 46622295)
33. W. De Roock, B. Claes, D. Bernasconi, J. De Schutter, B. Biesmans, and G. Fountzilas Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis Lancet Oncol 11 8 2010 753 762
34. J.P. Rodrigo, L.A. Garcia, S. Ramos, P.S. Lazo, and C. Suarez EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck Clin Cancer Res 6 8 2000 3177 3182 (Pubitemid 30637745)
35. E.S. Clark, B. Brown, A.S. Whigham, A. Kochaishvili, W.G. Yarbrough, and A.M. Weaver Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon Oncogene 28 3 2008 431 444
36. M.P. Tabor, R.H. Brakenhoff, H.J. Ruijter-Schippers, J.A. Kummer, C.R. Leemans, and B.J. Braakhuis Genetically altered fields as origin of locally recurrent head and neck cancer: a retrospective study Clin Cancer Res 10 11 2004 3607 3613 (Pubitemid 38697593)
37. J.F. Liu, X.K. Zhou, J.H. Chen, G. Yi, H.G. Chen, and M.C. Ba Up-regulation of PIK3CA promotes metastasis in gastric carcinoma World J Gastroenterol 16 39 2010 4986 4991
38. B.W. Murray, C. Guo, J. Piraino, J.K. Westwick, C. Zhang, and J. Lamerdin Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth Proc Natl Acad Sci USA 107 20 2010 9446 9451