Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1207-1221

  Del Giudice, Maria Rosaria ^a   Borioni, Anna ^a   Bastanzio, Giuditta ^a   Sbraccia, Maria ^a   Mustazza, Carlo ^a   Sestili, Isabella ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Bivalent ligand; NOP receptor antagonism; Quinoline; Synthesis

Indexed keywords

DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N (4 AMINO 2 METHYL 6 QUINOLINYL) 2 (4 ETHYLPHENOXYMETHYL)BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 (4 AMINOMETHYLPHENOXYMETHYL)BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 [4 (ALKYLAMINOMETHYL)PHENOXYMETHYL]BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 [4 (BUTYLIMINOMETHYL)PHENOXYMETHYL]BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 [4 (HEXYLIMINOMETHYL)PHENOXYMETHYL]BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 [4 (OMEGA AMINOALKYLAMINOMETHYL)PHENOXYMETHYL]BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 [4 (PENTYLIMINOMETHYL)PHENOXYMETHYL]BENZAMIDE; N (4 AMINO 2 METHYLQUINOLIN 6 YL) 2 [4 (PROPYLIMINOMETHYL)PHENOXYMETHYL]BENZAMIDE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,10 DECANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,3 PROPANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,4 BUTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,5 PENTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,6 HEXANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,7 HEPTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,8 OCTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYL] 1,9 NONANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,10 DECANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,3 PROPANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,4 BUTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,5 PENTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,6 HEXANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,7 HEPTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,8 OCTANEDIAMINE; N,N' BIS[[4 [[2 [[(4 AMINO 2 METHYLQUINOLIN 6 YL)AMINO]CARBONYL]PHENYL]METHOXY]PHENYL]METHYLENE] 1,9 NONANEDIAMINE; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; IC 50; PHARMACOPHORE;

AMINOQUINOLINES; BENZAMIDES; HUMANS; INHIBITORY CONCENTRATION 50; NARCOTIC ANTAGONISTS; RECEPTORS, OPIOID;

EID: 79952281730     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.040     Document Type: Article

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