Cardiovascular autonomic neuropathy in spontaneously diabetic rats with and without application of EGb 761

Histology and Histopathology

Volumn 25, Issue 12, 2010, Pages 1581-1590

  Schneider, Rick ^a   Welt, Klaus ^a   Aust, Wolfram ^a   Kluge, Regina ^a   Löster, Heinz ^a   Fitzl, Günther ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

123I MIBG imaging; Cardiovascular autonomic neuropathy; Diabetes; Egb 761; Oxidative stress

Indexed keywords

GINKGO BILOBA; RATTUS;

(3 IODOBENZYL)GUANIDINE; DIAGNOSTIC AGENT; GINKGO BILOBA EXTRACT 761; PLANT EXTRACT; RADIOPHARMACEUTICAL AGENT; SCAVENGER;

ANIMAL; ARTICLE; AUTONOMIC NEUROPATHY; DIABETIC CARDIOMYOPATHY; DIABETIC NEUROPATHY; EXPERIMENTAL DIABETES MELLITUS; FLUORESCENT ANTIBODY TECHNIQUE; HEART MUSCLE; IMMUNOHISTOCHEMISTRY; MALE; PATHOLOGY; RAT; SCINTISCANNING; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

3-IODOBENZYLGUANIDINE; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; DIABETIC NEUROPATHIES; FLUORESCENT ANTIBODY TECHNIQUE; FREE RADICAL SCAVENGERS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MYOCARDIUM; PLANT EXTRACTS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; RATS;

EID: 79952276959     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Addicks K., Boy C. and Rösen P. (1993). Sympathetic autonomic neuropathy in the heart of the spontaneous diabetic BB rat. Anat. Anz. 175, 253-257.
2. Altan V.M., Arioglu E., Guner S. and Ozcelikay A.T. (2007). The influence of diabetes on cardiac beta-adrenoceptor subtypes. Heart Fail. Rev. 12, 58-65.
3. Atkins F.L., Dowell R.T. and Love S. (1985). Beta-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in the diabetic rat. J. Cardiovasc. Pharmacol. 7, 66-70.
4. Bäcklund T., Palojoki E., Saraste A., Eriksson A., Finckenberg P., Kytö V., Lakkisto P., Mervaala E., Voipio-Pulkki L.M., Laine M. and Tikkanen I. (2004). Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes. Diabetologia 47, 325-330.
5. Bishop J.B., Tani Y., Witt K., Johnson J.A., Peddada S., Dunnick J. and Nyska A. (2004). Mitochondrial damage revealed by morphometric and semiquantitative analysis of mouse pup cardiomyocytes following in utero and postnatal exposure to zidovudine and lamivudine. Toxicol. Sci. 81, 512-517.
6. Brownlee M. (2001). Biochemistry and molecular cell biology of diabetic complications. Nature 414, 813-820.
7. Camacho V. and Carrió I. (2007). Targeting neuronal dysfunction and receptor imaging. Curr. Opin. Biotechnol. 18, 60-64.
8. Camici P.G. (2002). Imaging of cardiac adrenergic innervation. Heart 88, 209-210.
9. Cao J.M., Fishbein M.C., Han J.B., Lai W.W., Lai A.C., Wu T.J., Czer L., Wolf P.L., Denton T.A. and Shintaku I.P. (2000). Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation 101, 1960-1969.
10. Carrió I. (2001). Cardiac neurotransmission imaging. J. Nucl. Med. 42, 1062-1076.
11. Chen P.S., Chen L.S., Cao J.M., Sharifi B., Karagueuzian H.S. and Fishbein M.C. (2001). Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc. Res. 50, 409-416.
12. De Angelis K., Irigoyen M.C. and Morris M. (2009). Diabetes and cardiovascular autonomic dysfunction: application of animal models. Auton. Neurosci. 145, 3-10.
13. Debono M. and Cachia E. (2007). The impact of Cardiovascular Autonomic Neuropathy in diabetes: is it associated with left ventricular dysfunction? Auton. Neurosci. 132, 1-7.
14. Dinçer U.D., Bidasee K.R., Güner S., Tay A., Ozçelikay A.T. and Altan V.M. (2001). The effect of diabetes on expression of beta1-, beta2-, and beta3-adrenoreceptors in rat hearts. Diabetes 50, 455-461.
15. Gando S., Hattori Y. and Kanno M. (1993). Altered cardiac adrenergic neurotransmission in streptozotocin-induced diabetic rats. Br. J. Pharmacol. 109, 1276-1281.
16. Giraldez R.R., Panda A., Xia Y., Sanders S.P. and Zweier J.L. (1997). Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart. J. Biol. Chem. 272, 21420-21426.
17. Goldstein D.S. (2003). Imaging of the autonomic nervous system: focus on cardiac sympathetic innervation. Semin. Neurol. 23, 423-433.
18. Haenen G.R., Veerman M. and Bast A. (1990). Reduction of betaadrenoceptor function by oxidative stress in the heart. Free Radic. Biol. Med. 9, 279-288.
19. Huang M.T., Johnson E.F., Muller-Eberhard U., Koop D.R., Coon M.J. and Conney A.H. (1981). Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes. J. Biol. Chem. 256, 10897-10901.
20. Ieda M. and Fukuda K. (2009). New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: the regulatory mechanisms of cardiac innervation and their critical roles in cardiac performance. J. Pharmacol. Sci. 109, 348-353.
21. Jeon T.J., Lee J.D., Ha J.W., Yang W.I. and Cho S.H. (2000). Evaluation of cardiac adrenergic neuronal damage in rats with doxorubicin-induced cardiomyopathy using iodine-131 MIBG autoradiography and PGP 9.5 immunohistochemistry. Eur. J. Nucl. Med. 27, 686-693.
22. Kim S.J., Lee J.D., Ryu Y.H., Jeon P., Shim Y.W., Yoo H.S., Park C.Y. and Lim S.G. (1996). Evaluation of cardiac sympathetic neuronal integrity in diabetic patients using iodine-123 metaiodobenzylguanidine. Eur. J. Nucl. Med. 23, 401-406.
23. Kiyono Y., Kajiyama S., Fujiwara H., Kanegawa N. and Saji H. (2005). Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG. Eur. J. Nucl. Med. Mol. Imaging 32, 438-442.
24. Kusmic C., Morbelli S., Marini C., Matteucci M., Cappellini C., Pomposelli E., Marzullo P., L'abbate A. and Sambuceti G. (2008). Whole-body evaluation of MIBG tissue extraction in a mouse model of long-lasting type II diabetes and its relationship with norepinephrine transport protein concentration. J. Nucl. Med. 49, 1701-1706.
25. Liebgott T., Miollan M., Berchadsky Y., Drieu K., Culcasi M. and Pietri S. (2000). Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of ginkgo biloba extract (EGb 761) during ischemia and reperfusion. Basic Res. Cardiol. 95, 368-377.
26. Lohse M.J., Engelhardt S. and Eschenhagen T. (2003). What is the role of beta-adrenergic signaling in heart failure? Circ. Res. 93, 896-906.
27. Maser R.E. and Lenhard M.J. (2005). Cardiovascular autonomic neuropathy due to diabetes mellitus: clinical manifestations, consequences, and treatment. J. Clin. Endocrinol. Metab. 90, 5896-5903.
28. Park A.M., Armin S., Azarbal A., Lai A., Chen P.S. and Fishbein M.C. (2002). Distribution of cardiac nerves in patients with diabetes mellitus: an immunohistochemical postmortem study of human hearts. Cardiovasc. Pathol. 11, 326-331.
29. Pietri S., Maurelli E., Drieu K. and Culcasi M. (1997). Cardioprotective and anti-oxidant effects of the terpenoid constituents of ginkgo biloba extract (EGb 761). J. Mol. Cell. Cardiol. 29, 733-742.
30. Rösen P., Ballhausen T., Bloch W. and Addicks K. (1995). Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Diabetologia 38, 1157-1168.
31. Schmidt R.E., Beaudet L.N., Plurad S.B. and Dorsey D.A. (1997). Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia. Brain. Res. 769, 375-383.
32. Schmidt R.E., Dorsey D.A., Beaudet L.N., Frederick K.E., Parvin C.A., Plurad S.B. and Levisetti M.G. (2003). Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. Am. J. Pathol. 163, 2077-2091.
33. Schneider R., Welt K., Aust W., Löster H. and Fitzl G. (2008). Cardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761: I. cardiomyocytes. Histol. Histopathol. 23, 807-817.
34. Schneider R., Welt K., Aust W., Löster H. and Fitzl G. (2009). Cardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761: II. Interstitium and microvasculature. Histol. Histopathol. 24, 587-598.
35. Sethi R., Shao Q., Takeda N. and Dhalla N.S. (2003). Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril. J. Cell. Mol. Med. 7, 277-286.
36. Scott L.A. and Kench P.L. (2004). Cardiac autonomic neuropathy in the diabetic patient: does 123I-MIBG imaging have a role to play in early diagnosis? J. Nucl. Med. Technol. 32, 66-71.
37. Sharma V. and McNeill J.H. (2006). Diabetic cardiomyopathy: where are we 40 years later? Can. J. Cardiol. 22, 305-308.
38. Sharma V., Parsons H., Allard M.F. and McNeill J.H. (2008). Metoprolol increases the expression of beta(3)-adrenoceptors in the diabetic heart: effects on nitric oxide signaling and forkhead transcription factor-3. Eur. J. Pharmacol. 595, 44-51.
39. Standl E. and Schnell O. (2000). A new look at the heart in diabetes mellitus: from ailing to failing. Diabetologia 43, 1455-1469.
40. Taniguchi N., Arai K. and Kinoshita N. (1989). Glycation of copper/zinc superoxide dismutase and its inactivation: identification of glycated sites. Methods Enzymol. 179, 570-581.
41. Togane Y. (1999). Evaluation of the cardiac autonomic nervous system in spontaneously non-insulin-dependent diabetic rats by 123Imetaiodobenzylguanidine imaging. Ann. Nucl. Med. 13, 19-26.
42. Verberne H.J., Brewster L.M., Somsen G.A. and van Eck-Smit B.L. (2008). Prognostic value of myocardial 123I-metaiodobenzylguanidine (MIBG) parameters in patients with heart failure: a systematic review. Eur. Heart J. 29, 1147-1159.
43. Vinik A.I. and Ziegler D. (2007). Diabetic cardiovascular autonomic neuropathy. Circulation 115, 387-397.
44. Vinik A.I., Maser R.E., Mitchell B.D. and Freeman R. (2003). Diabetic autonomic neuropathy. Diabetes Care 26, 1553-1579.
45. Yagihashi S. (1995). Pathology and pathogenetic mechanisms of diabetic neuropathy. Diabetes Metab. Rev. 11, 193-225.
46. Yagihashi S. and Sima A.A. (1985). Diabetic autonomic neuropathy. The distribution of structural changes in sympathetic nerves of the BB rat. Am. J. Pathol. 121, 138-147.
47. Yagihashi S. and Sima A.A. (1986). Diabetic autonomic neuropathy in BB rat. Ultrastructural and morphometric changes in parasympathetic nerves. Diabetes 35, 733-743.
48. Yagihashi S., Zhang W.X. and Sima A.A. (1989). Neuroaxonal dystrophy in distal symmetric sensory polyneuropathy of the diabetic BB-rat. J. Diabet. Complications 3, 202-210.
49. Zhang X.M., Shen F., Xv Z.Y., Yan Z.Y. and Han S. (2005). Expression changes of thrombospondin-1 and neuropeptide Y in myocardium of STZ-induced rats. Int. J. Cardiol. 105, 192-197.
50. Zhu W.Z., Wang S.Q., Chakir K., Yang D., Zhang T., Brown J.H., Devic E., Kobilka B.K., Cheng H. and Xiao R.P. (2003). Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J. Clin. Invest. 111, 617-625.