Metoprolol increases the expression of β3-adrenoceptors in the diabetic heart: Effects on nitric oxide signaling and forkhead transcription factor-3

European Journal of Pharmacology

Volumn 595, Issue 1-3, 2008, Pages 44-51

  Sharma, Vijay ^a   Parsons, Hannah ^b   Allard, Michael F ^b   McNeill, John H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

Author keywords

adrenoceptor; Diabetic cardiomyopathy; Forkhead transcription factor; Metoprolol; Nitric oxide

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRUG VEHICLE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FORKHEAD TRANSCRIPTION FACTOR; FORKHEAD TRANSCRIPTION FACTOR 3; METOPROLOL; NITRIC OXIDE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE B; RECEPTOR SUBTYPE; STREPTOZOCIN; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CARDIOMYOPATHY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHY; DRUG MECHANISM; GENE EXPRESSION; HEART FUNCTION; HEART MUSCLE METABOLISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, EXPERIMENTAL; FORKHEAD TRANSCRIPTION FACTORS; MALE; METOPROLOL; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; SIGNAL TRANSDUCTION; UP-REGULATION; VENTRICULAR FUNCTION, LEFT;

EID: 52049103565     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.042     Document Type: Article

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