Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1421-1429

  Bateman, Katherine S ^a   Cherney, Maia M ^a   Mahuran, Don J ^b   Tropak, Michael ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE B; PYRIMETHAMINE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HYDROGEN BOND; LYSOSOME;

BETA-N-ACETYLHEXOSAMINIDASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN SUBUNITS; PYRIMETHAMINE;

EID: 79952262455     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101443u     Document Type: Article

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