Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions

International Journal of Molecular Medicine

Volumn 27, Issue 4, 2011, Pages 511-518

  Park, Chul Hong ^a   Nam, Dong Yoon ^a   Son, Hyeong U ^a   Lee, Si Rim ^a   Lee, Hyun Jin ^a   Heo, Jin Chul ^a   Cha, Tae Yang ^b   Baek, Jin Hong ^b   Lee, Sang Han ^a  

^a Kyungpook National University   (South Korea)

^b Kim Jeong Moon Aloe Company Ltd   (South Korea)

Author keywords

Aloe vera polymer fraction; Ethanol induction; Gastric ulceration; Matrix metalloproteinase; Nitric oxide synthase

Indexed keywords

ALCOHOL; ALOE VERA EXTRACT; ALOE VERA POLYMER FRACTION; BIOLOGICAL MARKER; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; OMEPRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DRUG MECHANISM; HUMAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH LESION; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER;

ALOE; ANIMALS; BIOLOGICAL MARKERS; ETHANOL; GASTRIC MUCOSA; GENE EXPRESSION PROFILING; INFLAMMATION; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; NITRIC OXIDE SYNTHASE; PLANT PREPARATIONS; POLYMERS; STOMACH ULCER;

EID: 79952261881     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.609     Document Type: Article

References (34)

1. Mózsik G, Dömötör A, Rumi G and Szekeres G: Gastrointestinal cytoprotection: from basic science to clinical perspectives. Inflammopharmacology 15: 49-60, 2007. (Pubitemid 46650838)
2. Cho CH and Ogle CW: The pharmacological differences and similarities between stress- and ethanol-induced gastric mucosal damage. Life Sci 51: 1833-1842, 1992.
3. Gyires K: Gastric mucosal protection: from prostaglandins to gene-therapy Curr Med Chem 12: 203-215, 2005.
4. Halter F, Tarnawski AS, Schmassmann A and Peskar BM: Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 49: 443-453, 2001. (Pubitemid 32802583)
5. Evangelista S: Role of sensory neurons in restitution and healing of gastric ulcers. Curr Pharm Des 12: 2977-2984, 2006.
6. Maity P, Biswas K, Roy S, Banerjee RK and Bandyopadhyay U: Smoking and the pathogenesis of gastroduodenal ulcer: recent mechanistic update. Mol Cell Biochem 253: 329-338, 2003. (Pubitemid 37321740)
7. Krishnan P: The scientific study of herbal wound healing therapies: current state of play. Curr Anaesth Crit Care 17: 21-27, 2006.
8. Ham M and Kaunitz JD: Gastroduodenal mucosal defense. Curr Opin Gastroenterol 24: 665-673, 2008.
9. Szabo S, Vincze A, Sandor Z, Jadus M, Gombos Z, Pedram A, Levin E, Hagar J and Iaquinto G: Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF Dig Dis Sci 43 (Suppl 9): 40S-45S, 1998.
10. Konturek SJ, Konturek PC and Brzozowski T: Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers. J Physiol Pharmacol 57 (Suppl 5): 51S-66S, 2006.
11. Hatazawa R, Ohno R, Tanigami M, Tanaka A and Takeuchi K: Roles of endogenous prostaglandins and cyclooxygenase isozyme in healing of indomethacin-induced small intestinal lesions in rats. J Pharmacol Exp Ther 318: 691-699, 2006. (Pubitemid 44061244)
12. Eamlamnam K, Patumraj S, Visedopas N and Thong-Ngam D: Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol 12: 2034-2039, 2006.
13. Yusuf S, Agunu A and Diana M: The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. J Ethnopharmacol 93: 33-37, 2004. (Pubitemid 38739266)
14. Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of Aloe andongensis extract, Aloe andongensis leaf juice, Aloe arborescens leaf extract, Aloe arborescens leaf juice, Aloe arborescens leaf protoplasts, Aloe barbadensis flower extract, Aloe barbadensis leaf, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf polysaccharides, Aloe barbadensis leaf water, Aloe ferox leaf extract, Aloe ferox leaf juice, and Aloe ferox leaf juice extract. Int J Toxicol 26 (S2): 1S-50S, 2007.
15. Chithra P and Sajithlal GB and Chandrakasan G: Influence of Aloe vera on the healing of dermal wounds in diabetic rats. J Ethnopharmacol 59: 195-201, 1998. (Pubitemid 28062299)
16. Davis RH, Donato JJ, Hartman GM and Haas RC: Antiinflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc 84: 77-81, 1994.
17. Baek J-H, Cha T-Y, Heo JC, Lee S-H and Lee S-Y: In vitro and in vivo physiological characteristics of dietary fiber from by-products of Aloe vera gel processing. Food Eng Prog 14: 173-182, 2010.
18. An SM, Park CH, Heo JC, Park JY, Woo SW, Seo JH, Lee MS, Cho KH, Shin HM and Lee S-H: Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice. Int J Mol Med 20: 209-215, 2007.
19. Julapalli VR and Graham DY: Appropriate use of intravenous proton pump inhibitors in the management of bleeding peptic ulcer. Dig Dis Sci 50: 1185-1193, 2005. (Pubitemid 41184741)
20. Heo JC, Rho JR, Kim TH, Kim SY and Lee SH: An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers. Int J Mol Med 22: 763-767, 2008.
21. Banerjee D, Bauri AK, Guha RK, Bandyopadhyay SK and Chattopadhyay S: Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. Eur J Pharmacol 578: 300-312, 2008.
22. Heo JC, Park JY, Woo SU, Rho JR, Lee HJ, Kim SU, Kho YH and Lee S-H: Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression. Biol Pharm Bull 29: 2256-2259, 2006.
23. Nie SN, Qian XM, Wu XH, Yang SY, Tang WJ, Xu BH, Huang F, Lin X, Sun DY, Sun HC and Li ZS: Role of TFF in healing of stress-induced gastric lesions. World J Gastroenterol 9: 1772-1776, 2003. (Pubitemid 37038128)
24. Lundberg JO, Weitzberg E and Gladwin MT: The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7: 156-167, 2008. (Pubitemid 351194063)
25. DeVault KR and Talley NJ: Insights into the future of gastric acid suppression. Nat Rev Gastroenterol Hepatol 6: 524-532, 2009.
26. Suvitayavat W, Bunyapraphatsara N, Thirawarapan SS and Watanabe K: Gastric acid secretion inbititory and gastric lesion protective effects of Aloe preparation. Thai J Phytopharm 4: 1-11, 1997.
27. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Drozdowicz D, Kwiecien S and Hahn EG: Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves. Regul Pept 82: 19-33, 1999. (Pubitemid 29308981)
28. Ma L, Chow JY and Cho CH: Cigarette smoking delays ulcer healing: role of constitutive nitric oxide synthase in rat stomach. Am J Physiol 276: 238-248, 1999.
29. Barrachina MD, Panes J and Esplugues JV: Role of nitric oxide in gastrointestinal inflammatory and ulcerative diseases: perspective for drugs development. Curr Pharm Des 7: 31-48, 2001. (Pubitemid 32409706)
30. Kankuri E, Vaali K, Knowles RG, Lahde M, Korpela R, Vapaatalo H and Moilanen E: Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine. J Pharmacol Exp Ther 298: 1128-1132, 2001. (Pubitemid 32761929)
31. Ding HL, Zhu HF, Dong JW, Zhu WZ, Yang WW, Yang HT and Zhou ZN: Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. Acta Pharmacol Sin 26: 315-322, 2005.
32. Shahin M, Konturek JW, Pohle T, Schuppan D, Herbst H and Domschke W: Remodeling of extracellular matrix in gastric ulceration. Microsc Res Technol 53: 396-408, 2001. (Pubitemid 32525714)
33. Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P and Sharma AV: Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 280: 9409-9415, 2005. (Pubitemid 40409634)
34. Pradeepkumar SL, Kundu P, Ganguly K, Mishra A and Swarnakar S: Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. Free Radic Biol Med 43: 289-299, 2007. (Pubitemid 46992709)