Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice

International Journal of Molecular Medicine

Volumn 20, Issue 2, 2007, Pages 209-215

  An, Sang Mi ^a   Park, Chul Hong ^a   Heo, Jin Chul ^a   Park, Ja Young ^a   Woo, Sang Uk ^a   Seo, Ji Hye ^a   Lee, Mi Soon ^a   Cho, Kang Jin ^b   Cho, Hyun Suk ^b   Shin, Heung Mook ^c   Lee, Sang Han ^a  

^a Kyungpook National University   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c Dongguk University   (South Korea)

Author keywords

Gastric lesion; Gastrodia elata Blume; Inducible nitric oxide synthase; RT PCR; Water immersion restraint stress

Indexed keywords

HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NOS1 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; NOS3 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; CHEMISTRY; DRUG EFFECT; EVALUATION; EXERCISE; GASTRODIA; GENE EXPRESSION REGULATION; GENETICS; IMMERSION; MALE; METABOLISM; MOUSE; PATHOLOGY; STOMACH DISEASE; STOMACH MUCOSA; STRESS;

ANIMALS; DRUGS, CHINESE HERBAL; GASTRIC MUCOSA; GASTRODIA; GENE EXPRESSION REGULATION; IMMERSION; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; RESTRAINT, PHYSICAL; RNA, MESSENGER; STOMACH DISEASES; STRESS;

EID: 35448932494     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.20.2.209     Document Type: Article

References (32)

1. Takagi KY, Kayuya Y and Watanabe K: Studies on drugs for peptic ulcer. A reliable method for producing stress ulcers in rats. Chem Pharm Bull 12: 465-472, 1964.
2. Brzozowski T, Konturek SJ, Kwiecien S, Pajdo R, Drozdowicz D, Sliwowski Z and Muramatsu M: SV-480, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity. J Physiol Pharmacol 46: 83-98, 1998.
3. Kwiecieñ S, Brzozowski T, Konturek PC, Konturek SJ, Pawlik M, Pajdo R, Drozdowicz D, Ptak A and Hahn EG: Effect of central and peripheral actions of histamine and its metabolite N-alpha methyl histamine on gastric secretion and acute gastric lesions. J Physiol Pharmacol 52: 625-638, 2001.
4. Konturek PC: Physiological, immunohistochemical and molecular aspects of gastric adaptation to stress, aspirin and to H. pylori-derived gastrotoxins. J Physiol Pharmacol 48: 3-42, 1997.
5. Brzozowski T, Konturek PC, Pajdo R, Kwiecien S, Ptak A, Sliwowski Z, Drozdowicz D, Pawlik M, Konturek SJ and Hahn EG: Brain-gut axis in gastroprotection by leptin and cholecystokinin against ischemia - reperfusion induced gastric lesions. J Physiol Pharmacol 52: 583-602, 2001.
6. Pawlik M, Ptak A, Pajdo R, Konturek PC, Brzozowski T and Konturek SJ: Sensory nerves and calcitonin gene related peptide in the effect of ischemic preconditioning on acute and chronic gastric lesions induced by ischemia-reperfusion. J Physiol Pharmacol 52: 569-581, 2001.
7. Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW and Murphy TJ: Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 90: 2092-2096, 1992.
8. Moncada S, Higgs EA and Furchgott R: International union of pharmacology nomenclature in nitric oxide research. Pharmacol Rev 49: 137-142, 1997.
9. Anggard E: Nitric oxide: mediator, murderer, and medicine. Lancet 343: 1199-1206, 1994.
10. Ma L, Chow JY and Cho CH: Cigarette smoking delays ulcer healing: Role of constitutive nitric oxide synthase in rat stomach. Am J Physiol 276: 238-248, 1999.
11. La Vecchia C and Tavani A: A review of epidemiological studies on cancer in relation to the use of anti-ulcer drugs. Eur J Cancer Prev 11: 117-123, 2002.
12. Schmeda-Hirschmann G and Yesilada E: Traditional medicine and gastroprotective crude drugs. J Ethnopharmacol 100: 61-66, 2005.
13. Huh K, Yi SJ, Shin US and Park JM: Effect of the ether fraction of Gastrodia elata methanol extract on the pentylenetetrazole-induced seizures. J Appl Pharmacol 3: 199-204, 1995.
14. Hsieh CL, Tang NY, Chiang SY, Hsieh CT and Lin JG: Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophylla (MIQ) Jack and Gastrodia elata Bl., in kainic acid-treated rats. Life Sci 65: 2071-2082, 1999.
15. Kim HJ, Moon KD, Oh SY, Kim SP and Lee SR: Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neurosci Lett 314: 65-68, 2001.
16. Brzozowski T, Konturek SJ, Sliwowski Z, Drozdowicz D, Zaczek M and Kedra D: Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. J Gastroenterol 32: 442-452, 1997. (Pubitemid 27367972)
17. Nie SN, Qian XM, Wu XH, Yang SY, Tang WJ, Xu BH, Huang F, Lin X, Sun DY, Sun HC and Li ZS: Role of TFF in healing of stress-induced gastric lesions. World J Gastroenterol 9: 1772-1776, 2003.
18. Dirsch VM, Stuppner H and Vollmar AM: The Griess assay: suitable for a bio-guided fractionation of anti-inflammatory plant extracts? Planta Med 64: 423-426, 1998.
19. Roos-van Groningen MC, Eikmans M, Baelde HJ, de Heer E and Bruijn JA: Improvement of extraction and processing of RNA from renal biopsies. Kidney Int 65: 97-105, 2004.
20. Kitagawa H, Fujiwara M and Osumi Y: Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology 77: 298-302, 1979.
21. Garrick T, Leung FW, Buack S, Hirabayashi K and Guth PH: Gastric motility is stimulated but overall blood flow is unaffected during cold restraint in the rat. Gastroenterology 91: 141-148, 1986.
22. Lamarque D and Whittle BJ: Involvement of superoxide and xanthine oxidase in neutrophil-independent rat gastric damage induced by NO donors. Br J Pharmacol 116: 1843-1848, 1995.
23. Calatayud S, Barrachina D and Esplugues JV: Nitric oxide: relation to integrity, injury, and healing of the gastric mucosa. Microsc Res Tech 53: 325-335, 2001.
24. Nishida K, Ohta Y and Ishiguro I: Role of gastric mucosal constitutive and inducible nitric oxide synthases in the development of stress-induced gastric mucosal lesions in rats. Biochem Biophys Res Commun 236: 275-279, 1997.
25. Brown JF, Hanson PJ and Whittle BJ: Nitric oxide donors increase mucus gel thickness in rat stomach. Eur J Pharmacol 223: 103-104, 1992.
26. Whittle BJ, Lopez-Belmonte J and Moncada S: Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 99: 607-611, 1990.
27. Pique JM, Esplugues JV and Whittle BJ: Endogenous nitric oxide as a mediator of gastric mucosal vasodilation during acid secretion. Gastroenterology 102: 168-174, 1992.
28. Konturek SJ, Brzozowski T, Majka J, Pytko-Polonczyk J and Stachura J: Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur J Pharmacol 239: 215-217, 1993.
29. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Drozdowicz D, Kwiecien S and Hahn EG: Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves. Regul Pept 82: 19-33, 1999.
30. Barrachina MD, Panes J and Esplugues JV: Role of nitric oxide in gastrointestinal inflammatory and ulcerative diseases: Perspective for drugs development. Curr Pharm Design 7: 31-48, 2001.
31. Kankuri E, Vaali K, Knowles RG, Lahde M, Korpela R, Vapaatalo H and Moilanen E: Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine. J Pharmacol Exp Ther 298: 1128-1132, 2001.
32. Ding HL, Zhu HF, Dong JW, Zhu WZ, Yang WW, Yang HT and Zhou ZN: Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. Acta Pharmacol Sin 26: 315-322, 2005.