Quality-by-design: An integrated process analytical technology approach to determine the nucleation and growth mechanisms during a dynamic pharmaceutical coprecipitation process

Journal of Pharmaceutical Sciences

Volumn 100, Issue 5, 2011, Pages 1969-1986

  Wu, Huiquan ^a   Khan, Mansoor A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Coprecipitation; Heterogeneous nucleation; Homogeneous nucleation; Induction; Kinetics; Mathematical modeling; Process analytical technology; Quality by Design; Regulatory science; Thermodynamics

Indexed keywords

EUDRAGIT; NAPROXEN;

ARTICLE; COPRECIPITATION; FEASIBILITY STUDY; MATHEMATICAL MODEL; NEAR INFRARED SPECTROSCOPY; PRECIPITATION; THERMODYNAMICS;

EID: 79952260305     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22430     Document Type: Article

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