Quality-by-Design (QbD): An integrated approach for evaluation of powder blending process kinetics and determination of powder blending end-point

Journal of Pharmaceutical Sciences

Volumn 98, Issue 8, 2009, Pages 2784-2798

  Wu, Huiquan ^a   Khan, Mansoor A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Blending end point determination; Design of experiments; Moving block standard deviation; Multivariate statistical data analysis; Powder blending; Process analytical technology (PAT); Process dynamics; Process monitoring; Quality by design (QbD)

Indexed keywords

EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; MICROCRYSTALLINE CELLULOSE;

ARTICLE; CHEMOMETRIC ANALYSIS; DRUG DESIGN; DRUG FORMULATION; DRUG MIXTURE; DRUG MONITORING; DRUG RELEASE; KINETICS; NEAR INFRARED SPECTROSCOPY; POWDER; PROCESS MONITORING; QUALITY CONTROL; SPECTROSCOPY;

EID: 68249125315     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21646     Document Type: Article

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