Wound inflammation in diabetic ob/ob mice: Functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing

Diabetes

Volumn 54, Issue 5, 2005, Pages 1543-1551

  Kämpfer, Heiko ^a   Schmidt, Ronald ^a   Geisslinger, Gerd ^a   Pfeilschifter, Josef ^a   Frank, Stefan ^a,b,c  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN; PROSTAGLANDIN D2; PROSTAGLANDIN E2; RECOMBINANT LEPTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; FEMALE; INFLAMMATION; KERATINOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; SYSTEMIC THERAPY; TISSUE DISTRIBUTION; WILD TYPE; WOUND HEALING;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIABETES MELLITUS, TYPE 2; DINOPROSTONE; DISEASE MODELS, ANIMAL; INFLAMMATION; LEPTIN; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECOMBINANT PROTEINS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 17844411514     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.5.1543     Document Type: Article

References (42)

1. Jeffcoate WJ, Harding KG: Diabetic foot ulcers. Lancet 361:1545-1651, 2003
2. Reiber GE, Lipsky BA, Gibbons GW: The burden of diabetic foot ulcers. Am J Surg 176:5S-10S, 1998
3. Ramsey SD, Newton K, Blough D, McCulloch DK, Sandhu N, Wagner EH: Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care 22:382-387, 1999
4. Apelqvist J, Larsson J, Agardh CD: Long-term prognosis for diabetic patients with foot ulcers. J Intern Med 233:485-491, 1993
5. Faglia E, Favales F, Morabito A: New ulceration, new major amputation, and survival rats in diabetic subjects hospitalized for foot ulceration from 1990 to 1993: a 6.5 year follow-up. Diabetes Care 24:78-83, 2001
6. Martin P: Wound healing: aiming for perfect skin regeneration. Science 276:75-81, 1997
7. Singer AJ, Clark RA: Cutaneous wound healing. N Engl J Med 341:738-746, 1999
8. Rosner K, Ross C, Karlsmark T, Petersen AA, Gottrup F, Vejlsgard GL: Immunohistochemical characterization of the cutaneous cellular infiltrate in different areas of chronic leg ulcers. APMIS 103:293-299, 1995
9. Loots MA, Lamme EN, Zeegelaar J, Mekkes JR, Bos JD, Middelloop E: Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 111:850-857, 1998
10. Wetsler C, Kämpfer H, Stallmeyer E, Pfeilschifter J, Frank S: Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J Invest Dermatol 115:245-253, 2000
11. Goren I, Kämpfer H, Podda M, Pfeilschifter J, Frank S: Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes 52:2821-2832, 2003
12. Coleman DL: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14:141-148, 1978
13. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
14. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495, 1996
15. Ahima RS, Saper CB, Flier JS, Elmquist JK: Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21:263-307, 2000
16. Fantuzzi G, Faggioni R: Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 68:437-446, 2000
17. Frank S, Stallmeyer B, Kämpfer H, Kolb N, Pfeilschifter J: Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest 106:501-509, 2000
18. Werner S, Grose R: Regulation of wound healing by growth factors and cytokines. Physiol Rev 83:835-870, 2003
19. Smith WL, Langenbach R: Why there are two cyclooxygenase isozymes. J Clin Invest 107:1491-1495, 2001
20. Tilley SL, Coffman TM, Koller BH: Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108:15-23, 2001
21. Smith WL, Garavito RM, DeWitt DL: Prostaglandin endoperoxidase H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271:33157-33160, 1996
22. Kämpfer H, Bräutigam L, Geisslinger G, Pfeilschifter J, Frank S: Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. J Invest Dermatol 120:880-890, 2003
23. Stallmeyer B, Kämpfer H, Kolb N, Pfeilschifter J, Frank S: The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization. J Invest Dermatol 113:1090-1098, 1999
24. Frank S, Stallmeyer B, Kämpfer H, Kolb N, Pfeilschifter J: Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair. FASEB J 13:2002-2014, 1999
25. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
26. Bräutigam L, Vetter G, Tegeder I, Heinkele G, Geisslinger G: Determination of celecoxib in human plasma and rat micodialysis samples by liquid chromatography tandem mass spectrometry. J Chromatogr B Biomed Sci Appl 761:203-212, 2001
27. Lee JL, Muhktar H, Bickers DR, Kopelovich L, Athar M: Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol Appl Pharmacol 192:294-306, 2003
28. DiPietro LA: Wound healing: the role of the macrophage and other immune cells. Shock 4:233-240, 1995
29. Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ, Willoughby DA: Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5:698-701, 1999
30. Blomme EA, Chinn KS, Hardy MM, Casler JJ, Kin SH, Opsahl AC, Hall WA, Trajkovic D, Khan KN, Tripp CS: Selective cyclooxygenase-2 inhibition does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice. Br J Dermatol 148:211-223, 2003
31. Müller-Decker K, Hirschner W, Marks F, Fürstenberger G: The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin. J Invest Dermatol 119:1189-1195, 2002
32. Wallace JL, Bak A, McKnight W, Asfaha S, Shrakey KA, McNaughton WK: Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology 115:101-109, 1998
33. Wallace JL, McKnight W, Reuter BK, Vergnolle N: NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 119:706-714, 2000
34. Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, Akamatsu T, Kasuga M: Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112:387-397, 1997
35. 2S and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways. J Biol Chem 274:3103-3115, 1999
36. 2 synthase that acts in concert with cylcooxygenase-2. J Biol Chem 275:32783-32792, 2000
37. 2 isoforms in mouse epidermis in vivo. Adv Exp Med Biol 400A:425-431, 1997
38. Pentland AP, Needleman P: Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis. J Clin Invest 77:246-251, 1986
39. Loftin CD, Eling TE: Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. Arch Biochem Biophys 330:419-429, 1996
40. Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, Dunson DB, Rogan EG, Morham SG, Smart RC, Langenbach R: Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 62:3395-3401, 2002
41. Jiang CY, Ting AT, Seed B: PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82-86, 1998
42. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK: The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79-82, 1998