Eicosapentaenoic acid decreases TNF-α and protects dystrophic muscles of mdx mice from degeneration

Journal of Neuroimmunology

Volumn 232, Issue 1-2, 2011, Pages 145-150

  Machado, Rafael Ventura ^a   Mauricio, Adriana Fogagnolo ^a   Taniguti, Ana Paula Tiemi ^a   Ferretti, Renato ^a   Neto, Humberto Santo ^a   Marques, Maria Julia ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Duchenne dystrophy; EPA; Mdx mice; Muscle degeneration; Sarcolemma leakiness; TNF

Indexed keywords

CREATINE KINASE; EVANS BLUE; ICOSAPENTAENOIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BICEPS BRACHII MUSCLE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; FEMALE; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE NECROSIS; MUSCULAR DYSTROPHY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STERNOCLEIDOMASTOID MUSCLE; WESTERN BLOTTING; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALS; BLOTTING, WESTERN; CREATINE KINASE; EICOSAPENTAENOIC ACID; FEMALE; MALE; MICE; MICE, INBRED MDX; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; NECROSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79952247629     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.10.032     Document Type: Article

References (45)

1. Acharyya S., Villalta S.A., Bakkar N., Bupha-Intr T., Janssen P.M., Carathers M., Li Z.W., Beg A.A., Ghosh S., Sahenk Z., Weinstein M., Gardner K.L., Rafael-Fortney J.A., Karin M., Tidball J.G., Baldwin A.S., Guttridge D.C. Interplay of IKK/NF-kappa α signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J. Clin. Investig. 2007, 117:889-901.
2. Arterburn L.M., Hall E.B., Oken H. Distribution, interconversion, and dose response of n_3 fatty acids in humans. Am. J. Clin. Nutr. 2006, 83:1467S-1476S.
3. Babcock T.A., Helton W.S., Espat N.J. Eicosapentaenoic acid (EPA): an antiinflammatory ω-3 fat with potential clinical applications. Nutrition 2000, 16:1116-1118.
4. Babcock T.A., Helton W.S., Hong D., Espat N.J. Omega-3 fatty acid lipid emulsion reduces LPS-stimulated macrophage TNF-α production. Surg. Inf. 2002, 3:145-149.
5. Barber M.D., Ross J.A., Voss A.C., Tisdale M.J., Fearon K.C.H. The effect of an oral nutritional supplement enriched with fish oil on weight loss in patients with pancreatic cancer. Br. J. Cancer 1999, 81:80-86.
6. Bloomer R.J., Larson D.E., Fisher-Wellman K.H., Galpin A.J., Schilling B.K. Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study. Lipids Health Dis. 2009, 8:36.
7. Bonifati M.D., Ruzza G., Bonometto P., Berardinelli A., Gorni K., Orcesi S., Lanzi G., Angelini C. A multicenter, double-blind randomized trial of deflazacort versus prednisone in Duchenne muscular dystrophy. Muscle Nerve 2000, 23:1344-1347.
8. Calder P.C. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol. Nutr. Food Res. 2008, 52:885-897.
9. Castillero E., Martín A.L., López-Menduiña M., Villanúa M., López-Calderón A. Eicosapentaenoic acid attenuates arthritis-induced muscle wasting acting on atrogin-1 and on myogenic regulatory factors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 297:R1322-R1331.
10. Chen Y.W., Zhao P., Borup R., Hoffman E.P. Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology. J. Cell Biol. 2000, 151:1321-1336.
11. Cullen M.J., Jaros E. Ultrastructure of the skeletal muscle in the X chromosome-linked dystrophic (mdx) mouse. Comparison with Duchenne muscular dystrophy. Acta Neuropathol. 1988, 77:69-81.
12. Engel A.G., Yamamoto M., Fischbeck K.H. Dystrophinopathies. Myology 1994, p. 1133-p. 1187. McGraw-Hill Inc, New York, NY. A.G. Engel, C. Franzini-Armstrong (Eds.).
13. Ferreti R., Marques M.J., Pertille A., Santo Neto H. Sarcoplasmic-endoplasmic-reticulum calcium-ATPase and calsequestrin are overexpressed in spared intrinsic laryngeal muscles of dystrophin-deficient mdx mice. Muscle Nerve 2009, 39:609-615.
14. Grounds M.D., Radley H.G., Gebski B.G., Bogoyevitch M.A., Shavlakadze T. Implications of cross-talk between tumor necrosis factor and insulin-like growth factor-1 signaling in skeletal muscle. Clin. Exp. Pharmacol. Physiol. 2008, 35:846-851.
15. Harper C.R., Edwards M.J., DeFilipis A.P., Jacobson T.A. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J. Nutr. 2006, 136:83-87.
16. Heemskerk H., Winter C., van Kuik P., Heuvelmans N., Sabatelli P., Rimessi P., Braghetta P., van Ommen G.-J., de Kimpe S., Ferlini A., Aartsma-Rus A., van Deutekom J.C.T. Preclinical PK and PD studies on 2'-O-methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model. Mol. Ther. 2010, 18:1210-1217.
17. Hodgetts S., Radley H.G., Davies M., Grounds M.D. Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNF alpha function with Etanercept in mdx mice. Neuromuscul. Disor. 2006, 16:591-602.
18. James M.J., Gibson R.A., Cleland L.G. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am. J. Clin. Nutr. 2000, 71:343S-348S.
19. Joussen A.M., Poulaki V., Mitsiades N., Kirchhof B., Koizumi K., Dohmen S., Adamis A.P. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNFalpha suppression. FASEB J. 2002, 16:438-440.
20. Kuru S., Inukai A., Kato T., Liang Y., Kimura S., Sobue G. Expression of tumor necrosis factor-α in regenerating muscle fibers in inflammatory and non-inflammatory myopathies. Acta Neuropathol. 2003, 105:217-224.
21. Lo C.J., Chiu K.C., Fu M., Lo R., Helton S. Fish oil augments macrophage cyclooxygenase II (COX-2) gene expression induced by endotoxin. J. Surg. Res. 1999, 86:103-107.
22. Magee P., Pearson S., Allen J. The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumor necrosis factor (TNF)-alpha during murine skeletal muscle differentiation. Lipids Health Dis. 2008, 7:24.
23. Marques M.J., Machado R., Minatel E., Santo Neto H. Disodium cromoglycate protects dystrophin-deficient muscle fibers from leakiness. Muscle Nerve 2008, 37:61-67.
24. Matsuda R.A., Nishikawa A., Tanaka H. Vizualization of dystrophic muscle fibers in mdx mouse by vital staining with Evans blue: evidence of apoptosis in dystrophin-deficient muscle. J. Biochem. 1995, 118:959-964.
25. Matsumoto T., Nakayama N., Ishida K., Kobayashi T., Kamata K. Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of Type 2 diabetes. J. Pharmacol. Exp. Ther. 2009, 329:324-334.
26. Monici M.C., Aguennouz M., Mazzeo A., Messina C., Vita G. Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology 2003, 60:993-997.
27. Moxley R.T., Ashwal S., Pandya S., Connolly A., Florence J., Mathews K., Baumbach L., McDonald C., Sussman M., Wade C. Practice parameter: corticosteroid treatment of Duchenne dystrophy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2005, 64:13-20.
28. Nestel P.J. Fish oil and cardiovascular disease: lipids and arterial function. Am. J. Clin. Nutr. 2000, 71:228S-231S.
29. Payne E.T., Yasuda N., Bourgeois J.M., Devries M.C., Rodriguez M.C., Yousuf J., Tarnopolsky M.A. Nutritional therapy improves function and complements corticosteroid intervention in mdx mice. Muscle Nerve 2006, 33:66-77.
30. Pierno S., Nico B., Burdi R., Liantonio A., Didonna M.P., Cippone V., Fraysse B., Rolland J.F., Mangieri D., Andreetta F., Ferro P., Camerino C., Zallone A., Confalonieri P., De Luca A. Role of tumor necrosis factor α, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach. Neuropathol. Appl. Neurobiol. 2007, 33:344-359.
31. Porter J.D., Khanna S., Kaminski H.J., Rao J.S., Merrian A.P., Richmonds C.R., Leahy P., Li J., Guo W., Andrade F.H. A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice. Hum. Mol. Genet. 2002, 11:263-272.
32. Radley H.G., De Luca A., Lynch G.S., Grounds M.D. Medicine in focus: Duchenne muscular dystrophy: focus on pharmaceutical and nutritional interventions. Int. J. Biochem. Cell Bio. 2007, 39:469-477.
33. Radley H.G., Grounds M.D. Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice. Neurobiol. Dis. 2006, 23:387-397.
34. Roulet M., Frascarolo P., Pilet M., Chapuis G. Effects of intravenously infused fish oil on platelet fatty acid phospholipid composition and on platelet function in postoperative trauma. J. Parenter. Enteral. Nutr. 1997, 21:296-301.
35. Saito K., Kobayashi D., Komatsu M., Yajima T., Yagihashi A., Ishikawa Y., Minami R., Watanabe N. A sensitive assay of tumor necrosis factor α in sera from Duchenne muscular dystrophy patients. Clin. Chem. 2000, 46:1703-1704.
36. Schlanger S., Shinitzky M., Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 2002, 43:103-104.
37. Singer P., Shapiro H., Theilla M., Anbar R., Singer J., Cohen J. Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and integrative perspective. Intensive Care Med 2008, 34:1580-1592.
38. Stedman H.H., Sweeney H.L., Shrager J.B., Maguirre H.C., Panettieri R.A., Petrof B., Narusawa M., Leferovich J.M., Sladky J.T., Kelly A.M. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature 1991, 352:536-539.
39. Tidball J.G. Inflammatory processes in muscle injury and repair. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R345-R353.
40. Tisdale M., Dhesi J.K. Inhibition of weight loss by Omega-3 fatty acids in an experimental cachexia model. Cancer Res. 1990, 50:5022-5026.
41. Tremblay J.P., Skuk D., Palmieri B., Rothstein D.M. A case for immunosuppression for myoblast transplantation in Duchenne muscular dystrophy. Mol. Ther. 2009, 17:1122-1124.
42. Vassalli P. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 1992, 10:411-452.
43. Villalta S.A., Nguyen H.X., Dengo B., Gotoh T., Tidball J.G. Shifts in macrophage phenotypes and macrophage competition for the arginine metabolism affect the severity of muscle pathology in muscular dystrophy. Human Mol. Gen. 2009, 18:482-496.
44. Waters F.J., Shavlakadze T., McIldowie M.J., Piggott M.J., Grounds M.D. Use of pifithrin to inhibit p53-mediated signaling of TNF in dystrophic muscles of mdx mice. Mol. Cell Biochem. 2010, 337:119-131.
45. Wehling M., Spencer M.J., Tidball J.G. A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice. J. Cell Biol. 2001, 155:123-131.