Genetic mapping identifies novel highly protective antigens for an apicomplexan parasite

PLoS Pathogens

Volumn 7, Issue 2, 2011, Pages

  Blake, Damer P ^a,b   Billington, Karen J ^a   Copestake, Susan L ^a   Oakes, Richard D ^a   Quail, Michael A ^c   Wan, Kiew Lian ^d,e   Shirley, Martin W ^a   Smith, Adrian L ^a,f  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d MALAYSIA GENOME INSTITUTE   (Malaysia)

^e UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APICAL MEMBRANE ANTIGEN 1; IMMUNE MAPPED PROTEIN 1; PARASITE ANTIGEN; PROTOZOAL VACCINE; UNCLASSIFIED DRUG;

APICOMPLEXA; ARTICLE; COCCIDIOSIS; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENOME; GENOME ANALYSIS; IMMUNITY; LIVESTOCK; NEOSPORA CANINUM; NONHUMAN; PLASMODIUM; PROTECTION; TOXOPLASMA GONDII; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; BIRD DISEASE; CELL PROTECTION; CHICKEN; CHROMOSOME MAP; FEMALE; GENETICS; HOST PARASITE INTERACTION; IMMUNE EVASION; IMMUNIZATION; IMMUNOLOGY; METHODOLOGY; PARASITE; PARASITOLOGY; PATHOLOGY;

EIMERIA; EIMERIA MAXIMA; NEOSPORA CANINUM; TOXOPLASMA GONDII;

ALGORITHMS; ANIMALS; ANTIGENS, PROTOZOAN; APICOMPLEXA; CHICKENS; CHROMOSOME MAPPING; CYTOPROTECTION; FEMALE; HOST-PARASITE INTERACTIONS; IMMUNE EVASION; IMMUNIZATION; MODELS, BIOLOGICAL; PARASITES; POULTRY DISEASES;

EID: 79952241046     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001279     Document Type: Article

References (31)

1. Dutta S, Lee SY, Batchelor AH, Lanar DE, (2007) Structural basis of antigenic escape of a malaria vaccine candidate. Proc Natl Acad Sci U S A 104: 12488-12493.
2. Melby P, Yang J, Zhao W, Perez L, Cheng J, (2001) Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis. Infect Immun 69: 4719-4725.
3. Godfray HC, Beddington JR, Crute IR, Haddad L, Lawrence D, et al. (2010) Food security: the challenge of feeding 9 billion people. Science 327: 812-818.
4. Perry B, Randolph T, McDermott J, Sones K, Thornton P, (2002) Investing in animal health research to alleviate poverty. ILRI (International Livestock Research Institute), Nairobi, Kenya.
5. Shirley MW, Smith AL, Tomley FM, (2005) The biology of avian Eimeria with an emphasis on their control by vaccination. Adv Parasitol 60: 285-330.
6. Blake DP, Hesketh P, Archer A, Carroll F, Smith AL, et al. (2004) Parasite genetics and the immune host: recombination between antigenic types of Eimeria maxima as an entree to the identification of protective antigens. Mol Biochem Parasitol 138: 143-152.
7. Martinelli A, Cheesman S, Hunt P, Culleton R, Raza A, et al. (2005) A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites. Proc Natl Acad Sci U S A 102: 814-819.
8. Maynard Smith J, Haigh J, (1974) The hitch-hiking effect of a favorable gene. Genet Res 23: 23-35.
9. Shirley M, Harvey D, (2000) A genetic linkage map of the apicomplexan protozoan parasite Eimeria tenella. Genome Res 10: 1587-1593.
10. Clark JD, Billington K, Bumstead JM, Oakes RD, Soon PE, et al. (2008) A toolbox facilitating stable transfection of Eimeria species. Mol Biochem Parasitol 162: 77-86.
11. Richie T, Saul A, (2002) Progress and challenges for malaria vaccines. Nature 415: 694-701.
12. Zhang H, Nishikawa Y, Yamagishi J, Zhou J, Ikehara Y, et al. (2010) Neospora caninum: Application of apical membrane antigen 1 encapsulated in the oligomannose-coated liposomes for reduction of offspring mortality from infection in BALB/c mice. Exp Parasitol 125: 130-136.
13. Kocken CH, van der Wel AM, Dubbeld MA, Narum DL, van de Rijke FM, et al. (1998) Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization. J Biol Chem 273: 15119-15124.
14. Dutta S, Dlugosz LS, Clayton JW, Pool CD, Haynes JD, et al. (2010) Alanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1. Infect Immun 78: 661-671.
15. Mu J, Myers RA, Jiang H, Liu S, Ricklefs S, et al. (2010) Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nat Genet 42: 268-271.
16. Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, et al. (2001) A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73: 56-65.
17. Kall L, Krogh A, Sonnhammer EL, (2004) A combined transmembrane topology and signal peptide prediction method. J Mol Biol 338: 1027-1036.
18. Bendtsen JD, Nielsen H, von Heijne G, Brunak S, (2004) Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340: 783-795.
19. Letunic I, Doerks T, Bork P, (2009) SMART 6: recent updates and new developments. Nucleic Acids Res 37: D229-232.
20. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
21. Cheesman S, O'Mahony E, Pattaradilokrat S, Degnan K, Knott S, et al. (2010) A single parasite gene determines strain-specific protective immunity against malaria: the role of the merozoite surface protein I. Int J Parasitol 40: 951-961.
22. Blake DP, Smith AL, Shirley MW, (2003) Amplified fragment length polymorphism analyses of Eimeria spp.: an improved process for genetic studies of recombinant parasites. Parasitol Res 90: 473-475.
23. Blake DP, Hesketh P, Archer A, Shirley MW, Smith AL, (2006) Eimeria maxima: the influence of host genotype on parasite reproduction as revealed by quantitative real-time PCR. Int J Parasitol 36: 97-105.
24. Eckert J, Braun R, Shirley M, Coudert P, (1995) Guidelines on techniques in coccidiosis research Brussels, Luxembourg European Commission.
25. Osoegawa K, Woon PY, Zhao B, Frengen E, Tateno M, et al. (1998) An improved approach for construction of bacterial artificial chromosome libraries. Genomics 52: 1-8.
26. Shirley MW, Kemp DJ, Pallister J, Prowse SJ, (1990) A molecular karyotype of Eimeria tenella as revealed by contour-clamped homogeneous electric field gel electrophoresis. Mol Biochem Parasitol 38: 169-173.
27. Vos P, Hogers R, Bleeker M, Reijans M, van de Lee T, et al. (1995) AFLP: a new technique for DNA fingerprinting. Nucleic Acids Res 23: 4407-4414.
28. Rozen S, Skaletsky H, (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.
29. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG, (1997) The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25: 4876-4882.
30. Thomason L, Court DL, Bubunenko M, Costantino N, Wilson H, et al. (2007) Recombineering: genetic engineering in bacteria using homologous recombination. Curr Protoc Mol Biol Chapter 1: Unit 1. 16.
31. Sambrook J, Russell D, (2001) Molecular cloning: a laboratory manual New York, USA Cold Spring Harbour Laboratory Press.