Involvement of semaphorins and their receptors in neurological diseases

Clinical and Experimental Neuroimmunology

Volumn 1, Issue 1, 2010, Pages 33-45

  Takegahara, Noriko ^a,b   Kumanogoh, Atsushi ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Autoimmune diseases; Immune regulation; Neurological diseases; Semaphorin receptors; Semaphorins

Indexed keywords

CD72 ANTIGEN; NEUROPILIN 1; PLEXIN; PLEXIN A1; PLEXIN A4; PLEXIN B1; SEMAPHORIN; SEMAPHORIN 3A; SEMAPHORIN 4A; SEMAPHORIN 4D; SEMAPHORIN 5A; SEMAPHORIN 6D; SEMAPHORIN 7A; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1;

ALLERGIC ENCEPHALOMYELITIS; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; DENDRITIC CELL; HTLV 1 ASSOCIATED MYELOPATHY; HUMAN; IMMUNE SYSTEM; LYMPHOCYTE DIFFERENTIATION; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NONHUMAN; OSTEOCLASTOGENESIS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 79952239289     PISSN: None     EISSN: 17591961     Source Type: Journal    
DOI: 10.1111/j.1759-1961.2009.00004.x     Document Type: Review

References (78)

1. Steinman L. Elaborate interactions between the immune and nervous systems. Nat Immunol. 2004; 5: 575-81. (Pubitemid 38811881)
2. Unified nomenclature for the semaphorins ? collapsins. Semaphorin nomenclature committee. Cell. 1999; 97:551-2.
3. Pasterkamp RJ, Kolodkin AL. Semaphorin junction: making tracks toward neural connectivity. Curr Opin Neurobiol. 2003; 13: 79-89. (Pubitemid 36197931)
4. Kolodkin AL, Matthes DJ, Goodman CS. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell. 1993; 75: 1389-99.
5. Zhou Y, Gunput RA, Pasterkamp RJ. Semaphorin signaling: progress made and promises ahead. Trends Biochem Sci. 2008; 33: 161-70.
6. Toyofuku T, Kikutani H. Semaphorin signaling during cardiac development. Adv Exp Med Biol. 2007; 600: 109-17.
7. Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, et al. Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1. EMBO J. 2007; 26: 1373-84. (Pubitemid 46398711)
8. Geretti E, Shimizu A, Klagsbrun M. Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis. Angiogenesis. 2008; 11: 31-9.
9. Casazza A, Fazzari P, Tamagnone L. Semaphorin signals in cell adhesion and cell migration: functional role and molecular mechanisms. Adv Exp Med Biol. 2007; 600: 90-108.
10. Giordano S, Corso S, Conrotto P, et al. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat Cell Biol. 2002; 4: 720-4. (Pubitemid 34993710)
11. Bielenberg DR, Klagsbrun M. Targeting endothelial and tumor cells with semaphorins. Cancer Metastasis Rev. 2007; 26: 421-31. (Pubitemid 350115126)
12. Kikutani H, Kumanogoh A. Semaphorins in interactions between T cells and antigen-presenting cells. Nat Rev Immunol. 2003; 3: 159-67. (Pubitemid 37328693)
13. Suzuki K, Kumanogoh A, Kikutani H. Semaphorins and their receptors in immune cell interactions. Nat Immunol. 2008; 9: 17-23. (Pubitemid 350286199)
14. Kikutani H, Suzuki K, Kumanogoh A. Immune semaphorins: increasing members and their diverse roles. Adv Immunol. 2007; 93: 121-43. (Pubitemid 46454331)
15. Winberg ML, Noordermeer JN, Tamagnone L, et al. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998; 95: 903-16. (Pubitemid 29019043)
16. Tamagnone L, Artigiani S, Chen H, et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999; 99: 71-80. (Pubitemid 29468631)
17. Takahashi T, Fournier A, Nakamura F, et al. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell. 1999; 99: 59-69. (Pubitemid 29468630)
18. Gu C, Yoshida Y, Livet J, et al. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005; 307: 265-8. (Pubitemid 40116243)
19. Pasterkamp RJ, Peschon JJ, Spriggs MK, Kolodkin AL. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003; 424: 398-405. (Pubitemid 36917482)
20. Suzuki K, Okuno T, Yamamoto M, et al. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature. 2007; 446: 680-4. (Pubitemid 46606878)
21. Toyofuku T, Zhang H, Kumanogoh A, et al. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes Dev. 2004; 18: 435-47. (Pubitemid 38316350)
22. Takegahara N, Takamatsu H, Toyofuku T, et al. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol. 2006; 8: 615-22. (Pubitemid 43827355)
23. Kumanogoh A, Watanabe C, Lee I, et al. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity. 2000; 13: 621-31.
24. Kumanogoh A, Marukawa S, Suzuki K, et al. Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. Nature. 2002; 419: 629-33.
25. Bougeret C, Mansur IG, Dastot H, et al. Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation. J Immunol. 1992; 148: 318-23.
26. Delaire S, Elhabazi A, Bensussan A, Boumsell L. CD100 is a leukocyte semaphorin. Cell Mol Life Sci. 1998; 54: 1265-76. (Pubitemid 28529116)
27. Swiercz JM, Kuner R, Behrens J, Offermanns S. Plexin-B1 directly interacts with PDZ-RhoGEF ? LARG to regulate RhoA and growth cone morphology. Neuron. 2002; 35: 51-63. (Pubitemid 34804322)
28. Oinuma I, Ishikawa Y, Katoh H, Negishi M. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science. 2004; 305: 862-5. (Pubitemid 39038420)
29. Adachi T, Flaswinkel H, Yakura H, Reth M, Tsubata T. The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol. 1998; 160: 4662-5. (Pubitemid 28215297)
30. Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem. 2001; 276: 26648-55.
31. Pan C, Baumgarth N, Parnes JR. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity. 1999; 11: 495-506. (Pubitemid 29504204)
32. Parnes JR, Pan C. CD72, a negative regulator of B-cell responsiveness. Immunol Rev. 2000; 176: 75-85.
33. Shi W, Kumanogoh A, Watanabe C, et al. The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice. Immunity. 2000; 13: 633-42.
34. Kumanogoh A, Suzuki K, Ch'ng E, et al. Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells. J Immunol. 2002; 169: 1175-81. (Pubitemid 34809157)
35. Wang X, Kumanogoh A, Watanabe C, Shi W, Yoshida K, Kikutani H. Functional soluble CD100 ? Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood. 2001; 97: 3498-504.
36. Zhu L, Bergmeier W, Wu J, et al. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci USA. 2007; 104: 1621-6. (Pubitemid 46214640)
37. Kumanogoh A, Shikina T, Suzuki K, et al. Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1 ? Th2 regulation in Sema4A-deficient mice. Immunity. 2005; 22: 305-16. (Pubitemid 40387473)
38. Chakravarti S, Sabatos CA, Xiao S, et al. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med. 2005; 202: 437-44. (Pubitemid 41126961)
39. Rennert PD, Ichimura T, Sizing ID, et al. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J Immunol. 2006; 177: 4311-21. (Pubitemid 44469759)
40. Yoshida Y, Han B, Mendelsohn M, Jessell TM. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006; 52: 775-88. (Pubitemid 44828453)
41. Wong AW, Brickey WJ, Taxman DJ, et al. CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat Immunol. 2003; 4: 891-8. (Pubitemid 37098660)
42. Bakker AB, Hoek RM, Cerwenka A, et al. DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity. 2000; 13: 345-53.
43. Kaifu T, Nakahara J, Inui M, et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest. 2003; 111: 323-32. (Pubitemid 36182208)
44. Yamada A, Kubo K, Takeshita T, et al. Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. J Immunol. 1999; 162: 4094-100. (Pubitemid 29314793)
45. Mine T, Harada K, Matsumoto T, et al. CDw108 expression during T-cell development. Tissue Antigens. 2000; 55: 429-36. (Pubitemid 30316153)
46. Tamagnone L, Comoglio PM. Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol. 2000; 10: 377-83. (Pubitemid 30612470)
47. Catalano A, Caprari P, Moretti S, Faronato M, Tamagnone L, Procopio A. Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function. Blood. 2006; 107: 3321-9.
48. Yamamoto M, Suzuki K, Okuno T, et al. Plexin-A4 negatively regulates T lymphocyte responses. Int Immunol. 2008; 20: 413-20. (Pubitemid 351321249)
49. Suto F, Tsuboi M, Kamiya H, et al. Interactions between plexin-A2, plexin-A4, and semaphorin 6A control laminarestricted projection of hippocampal mossy fibers. Neuron. 2007; 53: 535-47. (Pubitemid 46216759)
50. Tordjman R, Lepelletier Y, Lemarchandel V, et al. A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat Immunol. 2002; 3: 477-82. (Pubitemid 34520798)
51. Bruder D, Probst-Kepper M, Westendorf AM, et al. Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol. 2004; 34: 623-30. (Pubitemid 39255909)
52. Sarris M, Andersen KG, Randow F, Mayr L, Betz AG. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity. 2008; 28: 402-13.
53. Tian L, Rauvala H, Gahmberg CG. Neuronal regulation of immune responses in the central nervous system. Trends Immunol. 2009; 30: 91-9.
54. Popovich PG, Longbrake EE. Can the immune system be harnessed to repair the CNS? Nat Rev Neurosci. 2008; 9: 481-93.
55. Zipp F, Aktas O. The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci. 2006; 29: 518-27. (Pubitemid 44291819)
56. Tomasello E, Desmoulins PO, Chemin K, et al. Combined natural killer cell and dendritic cell functional deficiency in KARAP ? DAP12 loss-of-function mutant mice. Immunity. 2000; 13: 355-64.
57. Adams RH, Betz H, Puschel AW. A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. Mech Dev. 1996; 57: 33-45. (Pubitemid 26197735)
58. Goldberg JL, Vargas ME, Wang JT, et al. An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J Neurosci. 2004; 24: 4989-99. (Pubitemid 38697832)
59. Oster SF, Bodeker MO, He F, Sretavan DW. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. Development. 2003; 130: 775-84. (Pubitemid 36240585)
60. Pineda D, Garcia B, Olmos JL, Davila JC, Real MA, Guirado S. Semaphorin5A expression in the developing chick telencephalon. Brain Res Bull. 2005; 66: 436-40. (Pubitemid 41247691)
61. Clarimon J, Scholz S, Fung HC, et al. Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease. Am J Hum Genet. 2006; 78: 1082-4. (Pubitemid 43787701)
62. Bialecka M, Kurzawski M, Klodowska-Duda G, Opala G, Tan EK, Drozdzik M. Polymorphism in semaphorin 5A (Sema5A) gene is not a marker of Parkinson's disease risk. Neurosci Lett. 2006; 399: 121-3.
63. Ding H, Wang F, Ding X, et al. Association study of semaphorin 5A with risk of Parkinson's disease in a Chinese Han population. Brain Res. 2008; 1245: 126-9.
64. Hirsch E, Hu LJ, Prigent A, et al. Distribution of semaphorin IV in adult human brain. Brain Res. 1999; 823: 67-79. (Pubitemid 29225495)
65. Good PF, Alapat D, Hsu A, et al. A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimer's disease. J Neurochem. 2004; 91: 716-36. (Pubitemid 39431165)
66. Gu Y, Hamajima N, Ihara Y. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry. 2000; 39: 4267-75.
67. Yoshida H, Watanabe A, Ihara Y. Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. J Biol Chem. 1998; 273: 9761-8. (Pubitemid 28183069)
68. Cole AR, Knebel A, Morrice NA, et al. GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J Biol Chem. 2004; 279: 50176-80. (Pubitemid 39577830)
69. Uchida Y, Ohshima T, Sasaki Y, et al. Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells. 2005; 10: 165-79. (Pubitemid 40287519)
70. Schmidt ER, Pasterkamp RJ, van den Berg LH. Axon guidance proteins: novel therapeutic targets for ALS? Prog Neurobiol. 2009; 88: 286-301.
71. De Winter F, Vo T, Stam FJ, et al. The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Mol Cell Neurosci. 2006; 32: 102-17. (Pubitemid 43868100)
72. Giraudon P, Vincent P, Vuaillat C, et al. Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells. J Immunol. 2004; 172: 1246-55. (Pubitemid 38113788)
73. Majed HH, Chandran S, Niclou SP, et al. A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. J Neurosci. 2006; 26: 1730-8. (Pubitemid 43236985)
74. Minghetti L, Ajmone-Cat MA, De Berardinis MA, De SimoneR. Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation. Brain Res Brain Res Rev. 2005; 48: 251-6.
75. Yamaguchi J, Nakamura F, Aihara M, et al. Semaphorin3A alleviates skin lesions and scratching behavior in NC ? Nga mice, an atopic dermatitis model. J Invest Dermatol. 2008; 128: 2842-9.
76. Paloneva J, Kestila M, Wu J, et al. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nat Genet. 2000; 25: 357-61. (Pubitemid 30437329)
77. Cella M, Buonsanti C, Strader C, Kondo T, Salmaggi A, Colonna M. Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J Exp Med. 2003; 198: 645-51. (Pubitemid 37040398)
78. Takahashi K, Rochford CD, Neumann H. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med. 2005; 201: 647-57. (Pubitemid 40289554)