Androgen receptor signalling in prostate cancer: The functional consequences of acetylation

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Lavery, Derek N ^a   Bevan, Charlotte L ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABIRATERONE; ANDROGEN RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEPSIPEPTIDE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; KETOCONAZOLE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NUCLEAR RECEPTOR COREPRESSOR; PANOBINOSTAT; PROSTATE SPECIFIC ANTIGEN; PROTEIN KINASE B; PROTEIN P160; SIRTUIN 1; SMAD3 PROTEIN; STEROID RECEPTOR COACTIVATOR 1; VORINOSTAT;

ACETYLATION; CANCER GROWTH; CARCINOGENESIS; CHROMATIN IMMUNOPRECIPITATION; DRUG TARGETING; ENHANCER REGION; ENZYME ACTIVITY; HISTONE MODIFICATION; HUMAN; PEPTIDE ANALYSIS; PROMOTER REGION; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; ARTICLE; ENZYMOLOGY; MALE; METABOLISM; PROSTATE TUMOR;

ACETYLATION; ANIMALS; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; MALE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION;

EID: 79952224364     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/862125     Document Type: Review

References (67)

1. Parkin D. M., Bray F., Ferlay J., Pisani P., Global cancer statistics, 2002 CA Cancer J (Pubitemid 40372904)
2. Cunha G. R., Donjacour A. A., Cooke P. S., Mee S., Bigsby R. M., Higgins S. J., Sugimura Y., The endocrinology and developmental biology of the prostate Endocrine Reviews 1987 8 3 338 362
3. Gelmann E. P., Molecular biology of the androgen receptor Journal of Clinical Oncology 2002 20 13 3001 3015 (Pubitemid 34728896)
4. Feldman B. J., Feldman D., The development of androgen-independent prostate cancer Nature Reviews Cancer 2001 1 1 32 45
5. Brinkmann A. O., Blok L. J., De Ruiter P. E., Doesburg P., Steketee K., Berrevoets C. A., Trapman J., Mechanisms of androgen receptor activation and function Journal of Steroid Biochemistry and Molecular Biology 1999 69 16 307 313 (Pubitemid 29305551)
6. Lavery D. N., McEwan I. J., Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations Biochemical Journal 2005 391 3 449 464 (Pubitemid 41634771)
7. Claessens F., Gewirth D. T., DNA recognition by nuclear receptors Essays in Biochemistry 2004 40 59 72 (Pubitemid 38906672)
8. Nahoum V., Bourguet W., Androgen and estrogen receptors: potential of crystallography in the fight against cancer International Journal of Biochemistry and Cell Biology 2007 39 7-8 1280 1287 (Pubitemid 47031026)
9. Matias P. M., Donner P., Coelho R., Thomaz M., Peixoto C., Macedo S., Otto N., Joschko S., Scholz P., Wegg A., Bsler S., Schfer M., Egner U., Carrondo M. A., Structural evidence for ligand specificity in the binding domain of the human androgen receptor: implications for pathogenic gene mutations Journal of Biological Chemistry 2000 275 34 26164 26171
10. Jenster G., Van der Korput H. A. G. M., Trapman J., Brinkmann A. O., Identification of two transcription activation units in the N-terminal domain of the human androgen receptor Journal of Biological Chemistry 1995 270 13 7341 7346
11. Simental J. A., Sar M., Lane M. V., French F. S., Wilson E. M., Transcriptional activation and nuclear targeting signals of the human androgen receptor Journal of Biological Chemistry 1991 266 1 510 518 (Pubitemid 21906153)
12. Jenster G., Van der Korput H. A. G. M., Van Vroonhoven C., Van der Kwast T. H., Trapman J., Brinkmann A. O., Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization Molecular Endocrinology 1991 5 10 1396 1404
13. Heemers H. V., Tindall D. J., Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex Endocrine Reviews 2007 28 7 778 808 (Pubitemid 350294296)
14. Chmelar R., Buchanan G., Need E. F., Tilley W., Greenberg N. M., Androgen receptor coregulators and their involvement in the development and progression of prostate cancer International Journal of Cancer 2007 120 4 719 733 (Pubitemid 46175390)
15. Ward R. D., Weigel N. L., Steroid receptor phosphorylation: assigning function to site-specific phosphorylation BioFactors 2009 35 6 528 536
16. Fu M., Wang C., Reutens A. T., Wang J., Angeletti R. H., Siconolfi-Baez L., Ogryzko V., Avantaggiati M. L., Pestell R. G., p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation Journal of Biological Chemistry 2000 275 27 20853 20860 (Pubitemid 30457679)
17. Fu M., Rao M., Wang C., Sakamaki T., Wang J., Di Vizio D., Zhang X., Albanese C., Balk S., Chang C., Fan S., Rosen E., Palvimo J. J., Jnne O. A., Muratoglu S., Avantaggiati M. L., Pestell R. G., Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth Molecular and Cellular Biology 2003 23 23 8563 8575 (Pubitemid 37433362)
18. Fu M., Wang C., Zhang X., Pestell R., Nuclear receptor modifications and endocrine cell proliferation Journal of Steroid Biochemistry and Molecular Biology 2003 85 25 133 138 (Pubitemid 37011091)
19. Gaughan L., Logan I. R., Cook S., Neal D. E., Robson C. N., Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor Journal of Biological Chemistry 2002 277 29 25904 25913 (Pubitemid 34967070)
20. Brady M. E., Ozanne D. M., Gaughan L., Waite I., Cook S., Neal D. E., Robson C. N., Tip60 is a nuclear hormone receptor coactivator Journal of Biological Chemistry 1999 274 25 17599 17604
21. Gaughan L., Brady M. E., Cook S., Neal D. E., Robson C. N., Tip60 is a co-activator specific for class I nuclear hormone receptors Journal of Biological Chemistry 2001 276 50 46841 46848
22. Yamamoto T., Horikoshi M., Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60 Journal of Biological Chemistry 1997 272 49 30595 30598 (Pubitemid 27527486)
23. Fu M., Liu M., Sauve A. A., Jiao X., Zhang X., Wu X., Powell M. J., Yang T., Gu W., Avantaggiati M. L., Pattabiraman N., Pestell T. G., Wang F., Quong A. A., Wang C., Pestell R. G., Hormonal control of androgen receptor function through SIRT1 Molecular and Cellular Biology 2006 26 21 8122 8135 (Pubitemid 44631010)
24. Tanner T., Claessens F., Haelens A., The hinge region of the androgen receptor plays a role in proteasome-mediated transcriptional activation Annals of the New York Academy of Sciences 2004 1030 587 592 (Pubitemid 40378957)
25. Haelens A., Tanner T., Denayer S., Callewaert L., Claessens F., The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor Cancer Research 2007 67 9 4514 4523 (Pubitemid 46815103)
26. Tanner T. M., Denayer S., Geverts B., Tilborgh N. V., Kerkhofs S., Helsen C., Spans L., Dubois V., Houtsmuller A. B., Claessens F., Haelens A., A RKLKK motif in the hinge region controls the androgen receptor at multiple levels Cellular and Molecular Life Sciences 2010 67 11 1919 1927
27. Cutress M. L., Whitaker H. C., Mills I. G., Stewart M., Neal D. E., Structural basis for the nuclear import of the human androgen receptor Journal of Cell Science 2008 121 7 957 968 (Pubitemid 351639415)
28. Tilley W. D., Buchanan G., Hickey T. E., Bentel J. M., Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence Clinical Cancer Research 1996 2 2 277 285 (Pubitemid 26074615)
29. Meek D. W., Anderson C. W., Posttranslational modification of p53: cooperative integrators of function Cold Spring Harbor Perspectives in Biology 2009 1 6
30. Fu M., Rao M., Wu K., Wang C., Zhang X., Hessien M., Yeung Y. G., Gioeli D., Weber M. J., Pestell R. G., The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity Journal of Biological Chemistry 2004 279 28 29436 29449 (Pubitemid 38915823)
31. Wang L., Hsu C. L., Chang C., Androgen receptor corepressors: an overview Prostate 2005 63 2 117 130 (Pubitemid 40525362)
32. Jia L. I., Berman B. P., Jariwala U., Yan X., Cogan J. P., Walkers A., Chen T., Buchanan G., Frenkel B., Coetzee G. A., Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity PLoS ONE 2008 3 11
33. Kininis M., Kraus W. L., A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis Nuclear Receptor Signaling 2008 6, aticle e005
34. Xu J., Wu R. C., O'Malley B. W., Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family Nature Reviews Cancer 2009 9 9 615 630
35. Iyer N. G., zdag H., Caldas C., p300/CBP and cancer Oncogene 2004 23 24 4225 4231 (Pubitemid 38758588)
36. Culig Z., Comuzzi B., Steiner H., Bartsch G., Hobisch A., Expression and function of androgen receptor coactivators in prostate cancer Journal of Steroid Biochemistry and Molecular Biology 2004 92 4 265 271 (Pubitemid 40128247)
37. Spencer T. E., Jenster G., Burcin M. M., Allis C. D., Zhou J., Mizzen C. A., McKenna N. J., Onate S. A., Tsai S. Y., Tsai M. J., O'Malley B. W., Steroid receptor coactivator-1 is a histone acetyltransferase Nature 1997 389 6647 194 198 (Pubitemid 27400603)
38. Onate S. A., Boonyaratanakornkit V., Spencer T. E., Tsai S. Y., Tsai M. J., Edwards D. P., O'Malley B. W., The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors Journal of Biological Chemistry 1998 273 20 12101 12108 (Pubitemid 28240570)
39. McKenna N. J., Lanz R. B., O'Malley B. W., Nuclear receptor coregulators: cellular and molecular biology Endocrine Reviews 1999 20 3 321 344 (Pubitemid 30649811)
40. Bevan C. L., Hoare S., Claessens F., Heery D. M., Parker M. G., The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1 Molecular and Cellular Biology 1999 19 12 8383 8392 (Pubitemid 30414032)
41. Ikonen T., Palvimo J. J., Jnne O. A., Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators Journal of Biological Chemistry 1997 272 47 29821 29828 (Pubitemid 27508079)
42. Smith C. L., Oate S. A., Tsai M. J., O'Malley B. W., CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription Proceedings of the National Academy of Sciences of the United States of America 1996 93 17 8884 8888 (Pubitemid 26281986)
43. Bannister A. J., Kouzarides T., The CBP co-activator is a histone acetyltransferase Nature 1996 384 6610 641 643 (Pubitemid 27021517)
44. Vo N., Goodman R. H., CREB-binding Protein and p300 in Transcriptional Regulation Journal of Biological Chemistry 2001 276 17 13505 13508
45. Ogryzko V. V., Schiltz R. L., Russanova V., Howard B. H., Nakatani Y., The transcriptional coactivators p300 and CBP are histone acetyltransferases Cell 1996 87 5 953 959 (Pubitemid 26404293)
46. Yao T. P., Ku G., Zhou N., Scully R., Livingston D. M., The nuclear hormone receptor coactivator SRC-1 is a specific target of p300 Proceedings of the National Academy of Sciences of the United States of America 1996 93 20 10626 10631 (Pubitemid 26333038)
47. Mckenna N. J., Nawaz Z., Tsai S. Y., Tsai M. J., O'Malley B. W., Distinct steady-state nuclear receptor coregulator complexes exist in vivo Proceedings of the National Academy of Sciences of the United States of America 1998 95 20 11697 11702 (Pubitemid 28460477)
48. Shang Y., Myers M., Brown M., Formation of the androgen receptor transcription complex Molecular Cell 2002 9 3 601 610 (Pubitemid 34273790)
49. Kang Z., Jnne O. A., Palvimo J. J., Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor Molecular Endocrinology 2004 18 11 2633 2648 (Pubitemid 39482054)
50. Kang Z., Pirskanen A., Jnne O. A., Palvimo J. J., Involvement of proteasome in the dynamic assembly of the androgen receptor transcription complex Journal of Biological Chemistry 2002 277 50 48366 48371 (Pubitemid 35470792)
51. Wang Q., Carroll J. S., Brown M., Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking Molecular Cell 2005 19 5 631 642 (Pubitemid 41219439)
52. Louie M. C., Yang H. Q., Ma AI. H., Xu W., Zou J. X., Kung H. J., Chen H. W., Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2226 2230 (Pubitemid 36297481)
53. Gaughan L., Logan I. R., Neal D. E., Robson C. N., Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation Nucleic Acids Research 2005 33 1 13 26 (Pubitemid 40276925)
54. Villaronga M. A., Lavery D. N., Bevan C. L., Llanos S., Belandia B., HEY1 Leu94Met gene polymorphism dramatically modifies its biological functions Oncogene 2010 29 3 411 420
55. Belandia B., Powell S. M., Garca-Pedrero J. M., Walker M. M., Bevan C. L., Parker M. G., Hey1, a mediator of Notch signaling, is an androgen receptor corepressor Molecular and Cellular Biology 2005 25 4 1425 1436 (Pubitemid 40204919)
56. Fu M., Wang C., Zhang X., Pestell R. G., Acetylation of nuclear receptors in cellular growth and apoptosis Biochemical Pharmacology 2004 68 6 1199 1208 (Pubitemid 39094285)
57. Popov V. M., Wang C., Shirley L. A., Rosenberg A., Li S., Nevalainen M., Fu M., Pestell R. G., The functional significance of nuclear receptor acetylation Steroids 2007 72 2 221 230 (Pubitemid 46273505)
58. Chen YU., Sawyers C. L., Scher H. I., Targeting the androgen receptor pathway in prostate cancer Current Opinion in Pharmacology 2008 8 4 440 448
59. Brooke G. N., Bevan C. L., The role of androgen receptor mutations in prostate cancer progression Current Genomics 2009 10 1 18 25
60. Attard G., Sarker D., Reid A., Molife R., Parker C., De Bono J. S., Improving the outcome of patients with castration-resistant prostate cancer through rational drug development British Journal of Cancer 2006 95 7 767 774 (Pubitemid 44498089)
61. Shen LI., Pili R., Posttranscription regulation of prostate cancer growth Cancer Journal 2008 14 1 46 53
62. Chen L., Meng S., Wang H., Bali P., Bai W., Li B., Atadja P., Bhalla K. N., Wu J., Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824 Molecular Cancer Therapeutics 2005 4 9 1311 1319
63. Chen C. S., Wang YU. C., Yang H. C., Huang PO. H., Kulp S. K., Yang C. C., Lu Y. S., Matsuyama S., Chen C. Y., Chen C. S., Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation Cancer Research 2007 67 11 5318 5327 (Pubitemid 46997271)
64. Manzo F., Tambaro F. P., Mai A., Altucci L., Histone acetyltransferase inhibitors and preclinical studies Expert Opinion on Therapeutic Patents 2009 19 6 761 774
65. Dekker F. J., Haisma H. J., Histone acetyl transferases as emerging drug targets Drug Discovery Today 2009 14 19-20 942 948
66. Balasubramanyam K., Varier R. A., Altaf M., Swaminathan V., Siddappa N. B., Ranga U., Kundu T. K., Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription Journal of Biological Chemistry 2004 279 49 51163 51171 (Pubitemid 40017859)
67. Khan N., Adhami V. M., Mukhtar H., Apoptosis by dietary agents for prevention and treatment of prostate cancer Endocrine-Related Cancer 2010 17 1 R39 R5