Industrial oseltamivir synthesis: How reliable was the oseltamivir supply in times of influenza pandemic?;Industrielle oseltamivir-synthese: Wie sicher war die oseltamivir- versorgung in zeiten der grippe-pandemie?

Pharmazie in Unserer Zeit

Volumn 40, Issue 2, 2011, Pages 151-154

  Holzgrabe, Ulrike ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

OSELTAMIVIR; ANTIVIRUS AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; SIALIDASE;

ARTICLE; DRUG SYNTHESIS; PANDEMIC INFLUENZA; DRUG ANTAGONISM; DRUG INDUSTRY; HUMAN; INFLUENZA; PANDEMIC; REVIEW; STATISTICS; SYNTHESIS; VIROLOGY;

ANTIVIRAL AGENTS; DRUG INDUSTRY; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; INFLUENZA, HUMAN; NEURAMINIDASE; OSELTAMIVIR; PANDEMICS;

EID: 79952212925     PISSN: 00483664     EISSN: 16151003     Source Type: Journal    
DOI: 10.1002/pauz.201100411     Document Type: Article

References (7)

1. Tremblay, J.-F.: Roche raises output of bird flu drug. Chem. Eng. News Aug. (2005), 20-22.
2. Rohloff, J.C., Kent, K.M., Postich, M.J., Becker, M.W., Chapman, H.H., et al.: Practical Total Synthesis of the Anti-Influenza Drug. J. Org. Chem. 63 (1998), 4545-4550. (Pubitemid 28334273)
3. Abrecht, S., Federspiel, M.C., Estermann, H., Fischer, R., Karpf, M., et al.: The Synthetic-Technical Development of Oseltamivir Phosphate Tamiflu: A race against Time. Chimia 61 (2007), 93-99.
4. Knop, D.R,, Draths, K.M., Chandran, S.C., Barker, J.L., Von Daeniken, R., Weber, W., Frost, J.W.: Hydroaromatic Equilibration during Biosynthesis of Shikimi Acid. J. Am. Chem. Soc. 123 (2001), 10173-10182. (Pubitemid 32979765)
5. Graening, T.: Wie konkurrenzfähig sind akademische Tamiflu-Synthesen? Nachrichten Chem. 57 (2009), 654-659.
6. Shibasaki, M., Kanai, M.: Synthestic Strategies for Oseltamivir Phosphate. Eur. J. Org. Chem. Vol. April (2008), 1839-1850.
7. Karpf, M., Trussardi, R.: New, Azide-free Transformation of Epoxides into 1,2-Diamino Compounds: Synthesis of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu®). J. Org. Chem. 66 (2001), 2044-2051. (Pubitemid 32867334)