Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of mapk p38

Molecular Nutrition and Food Research

Volumn 54, Issue 10, 2010, Pages 1458-1467

  Kuntz, Sabine ^a   Kunz, Clemens ^a   Rudloff, Silvia ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Glyoxal; Interleukin 8; Methylglyoxal; p38 MAPK; Superoxide anion

Indexed keywords

ENZYME INHIBITOR; GLYOXAL; IL8 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; METHYLGLYOXAL; MITOGEN ACTIVATED PROTEIN KINASE P38; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; CELL STRAIN CACO 2; CELL STRAIN HT29; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HUMAN; INTESTINE MUCOSA; METABOLISM; OSMOLARITY; OXIDATIVE STRESS; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; SIGNAL TRANSDUCTION;

CACO-2 CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYOXAL; HT29 CELLS; HUMANS; INTERLEUKIN-8; INTESTINAL MUCOSA; NADPH OXIDASE; NF-KAPPA B; OSMOLAR CONCENTRATION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRUVALDEHYDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 79952202333     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200900408     Document Type: Article

References (42)

1. Han, Y., Randell, E., Vasdev, S., Gill, V. et al., Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes. Mol. Cell. Biochem. 2007, 305, 131–132.
2. Uribarri, J., Cai, W., Peppa, M., Goodman, S. et al., Circulating glycotoxins and dietary advanced glycation end products: two links to inflammatory response, oxidative stress, and aging. J. Gerontol. A. Biol. Sci. Med. Sci. 2007, 62, 427–433.
3. Yamawaki, H., Saito, K., Okada, M., Hara, Y., Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells. Am. J. Physiol. Cell. Physiol. 2008, 295, 1510–1517.
4. Migliore, L., Barale, R., Bosco, E., Giorgelli, F. et al., Geno-toxicity of methylglyoxal: cytogenetic damage in human lymphocytes in vitro and in intestinal cells of mice. Carcinogenesis. 1990, 11, 1503–1507.
5. Baskaran, S., Balasubramanian, K. A., Effect of methylglyoxal on protein thiol and amino groups in isolated rat enterocytes and colonocytes and activity of various brush border enzymes. Indian J. Biochem. Biophys. 1990, 27, 13–17.
6. Baskaran, S., Balasubramanian, K. A., Toxicity of methylglyoxal towards rat enterocytes and colonocytes. Biochem. Int. 1990, 21, 165–174.
7. Harada, A., Sekido, N., Akahoshi, T., Wada, T. et al., Essential involvement of interleukin-8 (IL-8) in acute inflammation. J. Leukoc. Biol. 1994, 56, 559–564.
8. Pedersen, G., Saermark, T., Bendtzen, K., Brynskov, J., Cultures of human colonic epithelial cells isolated from endoscopical biopsies from patients with inflammatory bowel disease, Effect of IFNgamma, TNFalpha and IL-1beta on viability, butyrate oxidation and IL-8 secretion. Auto-immunity. 2000, 32, 255–263.
9. Reimund,J.M.,Wittersheim,C.,Dumont,S.,Muller,C.D., Baumann, R. et al., Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn’s disease. J. Clin. Immunol. 1996, 16, 144–150.
10. Ishiguro, Y., Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J. Gastroenterol. 1999, 34, 66–74.
11. Kuntz, S., Rudloff, S., Ehl, J., Bretzel, R. G. et al., Food derived carbonyl compounds affect basal and stimulated secretion of interleukin-6 and-8 in Caco-2 cells. Eur. J. Nutr. 2009, 48, 499–503.
12. Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., Kracht, M., Multiple control of interleukin-8 gene expression. J. Leukoc. Biol. 2002, 72, 847–855.
13. Pitzschke, A., Djamei, A., Bitton, F., Hirt, H., A major Role of the MEKK1-MKK1/2-MPK4 Pathway in ROS signalling. Mol. Plant. 2009, 2, 120–137.
14. Desai, K. M., Wu, L., Free radical generation by methylglyoxal in tissues. Drug Metabol. Drug Interact. 2008, 23, 151–173.
15. Taniguchi, N., Takahashi, M., Sakiyama, H., Park, Y. S. et al., A common pathway for intracellular reactive oxygen species production by glycoxidative and nitroxidative stress in vascular endothelial cells and smooth muscle cells. Ann. N. Y. Acad. Sci. 2005, 1043, 521–528.
16. Wu, L., Juurlink, B. H., Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells. Hypertension. 2002, 1, 809–814.
17. Kuntz, S., Kunz, C., Rudloff, S., Oligosaccharides from human milk induce growth arrest via G2/M by influencing growth-related cell cycle genes in intestinal epithelial cells. Br. J. Nutr. 2009, 101, 1306–1315.
18. Yamawaki, H., Hara, Y., Glyoxal causes inflammatory injury in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 2008, 369, 1155–1159.
19. Wu, L., The pro-oxidant role of methylglyoxal in mesenteric artery smooth muscle cells. Can. J. Physiol. Pharmacol. 2005, 83, 63–68.
20. Ankrah, N. A., Appiah-Opong, R., Toxicity of low levels of methylglyoxal: depletion of blood glutathione and adverse effect on glucose tolerance in mice. Toxicol. Lett. 1999, 109, 61–67.
21. Pacifici, G. M., Franchi, M., Gervasi, P. G., Longo, V. et al., Profile of drug-metabolizing enzymes in human ileum and colon. Pharmacology. 1989, 38, 137–145.
22. Ciaccio, P. J., Shen, H., Jaiswal, A. K., Lyttle, M. H. et al., Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors. Mol. Pharmacol. 1995, 48, 639–647.
23. Santel, T., Pflug, G., Hemdan, N. Y., Schafer, A. et al., Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity. PLoS One 2008, 3, e3508.
24. Harimaya, A., Koizumi, J., Fujii, N., Himi, T., Interleukin-8 induction via NF-kappaB, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase1/2 pathways in human peripheral blood mononuclear cells by Alloiococcus otitidis. Int. J. Pediatr. Otorhinolaryngol. 2007, 71, 1465–1470.
25. Choi, E. Y., Park, Z. Y., Choi, E. J., Oh, H. M. et al., Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2-and p38 kinase-dependent activation of AP-1. J. Cell. Biochem. 2007, 102, 1442–1457.
26. Liu, B. F., Miyata, S., Hirota, Y., Higo, S. et al., Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells. Kidney. Int. 2003, 63, 947–957.
27. Fukunaga, M., Miyata, S., Higo, S., Hamada, Y. et al., Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells. Ann. N. Y. Acad. Sci. 2005, 1043, 151–157.
28. Schieven, G. L., The biology of p38 kinase: a central role in inflammation. Curr. Top. Med. Chem. 2005, 5, 921–928.
29. Jiang, Y., Chen, C., Li, Z., Guo, W. et al., Characterizationof the structure and function of a new mitogen-activated protein kinase p38(beta). J. Biol. Chem. 1996, 271, 17920–17926.
30. Kim, C., Sano, Y., Todorova, K., Carlson, B. A. et al., The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro-and anti-inflammatory gene expression. Nat. Immunol. 2008, 9, 1019–1027.
31. Portero-Otín, M., Pamplona, R., Bellmunt, M. J., Ruiz, M. C. et al., Advanced glycation end product precursors impair epidermal growth factor receptor signaling. Diabetes. 2002, 51, 1535–1542.
32. O’Brien, D., O’Connor, T., Shanahan, F., O’Connell, J., Activation of the p38 MAPK and ERK1/2 pathways is required for Fas-induced IL-8 production in colonic epithelial cells. Ann. N. Y. Acad. Sci. 2002, 973, 161–165.
33. Akhand, A. A., Hossain, K., Mitsui, H., Kato, M. et al., Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells. Free Radic. Biol. Med. 2001, 31, 20–30.
34. Zhou, Y., Wang, Q., Evers, B., Chung, D. H., Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK. Biochem. Biophys. Res. Commun. 2006, 350, 860–865.
35. Torres, M., Forman, H. J., Redox signaling and the MAP kinase pathways. Biofactors. 2003, 17, 287–296.
36. Nakayama, M., Saito, K., Sato, E., Nakayama, K. et al., Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide. Redox Rep. 2007, 12, 125–133.
37. Hsuuw, Y. D., Chang, C. K., Chan, W. H., Yu, J. S., Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts. J. Cell Physiol. 2005, 205, 379–386.
38. Fan, X., Subramaniam, R., Weiss, M. F., Monnier, V. M., Methylglyoxal-bovine serum albumin stimulates tumor necrosis factor alpha secretion in RAW 264,7 cells through activation of mitogen-activating protein kinase, nuclear factor kappaB and intracellular reactive oxygen species formation. Arch. Biochem. Biophys. 2003, 409, 274–286.
39. Pal, A., Bhattacharya, I., Bhattacharya, K., Mandal, C. et al., Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in sarcoma-180 bearing mice: involvement of MAP kinase, NF-kappa beta signal transduction pathway. Mol. Immunol. 2009, 46, 2039–2044.
40. Muselet-Charlier, C., Roque, T., Boncoeur, E., Chadelat, K. et al., Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling. Biochem. Biophys. Res. Commun. 2007, 357, 402–407.
41. Lee, J. Y., Kim, J. S., Kim, J. M., Kim, N. et al., Simvastatin inhibits NF-kappaB signaling in intestinal epithelial cells and ameliorates acute murine colitis. Int. Immunopharmacol. 2007, 7, 241–248.
42. Kishore, N., Sommers, C., Mathialagan, S., Guzova, J. et al., A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J. Biol. Chem. 2003, 278, 32861–32871.