Impaired IFN-γ production after stimulation with bacterial components by natural killer cells from gastric cancer patients

Experimental Cell Research

Volumn 317, Issue 6, 2011, Pages 849-858

  Lindgren, Asa ^a   Yun, Cheol Heui ^a,b   Sjöling, Asa ^a   Berggren, Camilla ^a   Sun, Jia Bin ^a   Jonsson, Erik ^c   Holmgren, Jan ^a   Svennerholm, Ann Mari ^a   Lundin, Samuel B ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Seoul National University   (South Korea)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Gastric cancer; Human; IFN ; NK cell; TGF

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; LIPOPROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; BLOOD; CELL FUNCTION; CELL LYSATE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; STOMACH MUCOSA;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

EID: 79952189180     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.01.006     Document Type: Article

References (48)

1. The World Health Report 1997-conquering suffering, enriching humanity. World Health Forum 1997, 18:248-260.
2. Sikora K. Developing a global strategy for cancer. Eur. J. Cancer 1999, 35:24-31.
3. Parkin D.M., Pisani P., Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int. J. Cancer 1999, 80:827-841.
4. Parsonnet J., Friedman G.D., Vandersteen D.P., Chang Y., Vogelman J.H., Orentreich N., Sibley R.K. Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 1991, 325:1127-1131.
5. Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut 1993, 34:1672-1676. The EUROGAST Study Group.
6. An international association between Helicobacter pylori infection and gastric cancer. Lancet 1993, 341:1359-1362. The EUROGAST Study Group.
7. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monogr. Eval. Carcinog. Risks Hum. 1994, 61:1-241. Lyon.
8. Mandelboim O., Malik P., Davis D.M., Jo C.H., Boyson J.E., Strominger J.L. Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity. Proc. Natl Acad. Sci. USA 1999, 96:5640-5644.
9. Morelli L., Lemieux S. Triggering of the cytotoxic activity of murine natural killer and lymphokine-activated killer cells through the NK2.1 antigen. J. Immunol. 1993, 151:6783-6793.
10. van den Broek M.E., Kagi D., Ossendorp F., Toes R., Vamvakas S., Lutz W.K., Melief C.J., Zinkernagel R.M., Hengartner H. Decreased tumor surveillance in perforin-deficient mice. J. Exp. Med. 1996, 184:1781-1790.
11. Kodama T., Takeda K., Shimozato O., Hayakawa Y., Atsuta M., Kobayashi K., Ito M., Yagita H., Okumura K. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12. Eur. J. Immunol. 1999, 29:1390-1396.
12. Smyth M.J., Thia K.Y., Cretney E., Kelly J.M., Snook M.B., Forbes C.A., Scalzo A.A. Perforin is a major contributor to NK cell control of tumor metastasis. J. Immunol. 1999, 162:6658-6662.
13. Street S.E., Cretney E., Smyth M.J. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 2001, 97:192-197.
14. Biron C.A., Nguyen K.B., Pien G.C., Cousens L.P., Salazar-Mather T.P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 1999, 17:189-220.
15. Moretta L., Mingari M.C., Bottino C., Pende D., Biassoni R., Moretta A. Cellular and molecular basis of natural killer and natural killer-like activity. Immunol. Lett. 2003, 88:89-93.
16. Doolan D.L., Hoffman S.L. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J. Immunol. 1999, 163:884-892.
17. Giavedoni L.D., Velasquillo M.C., Parodi L.M., Hubbard G.B., Hodara V.L. Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus. J. Virol. 2000, 74:1648-1657.
18. Scharton-Kersten T., Afonso L.C., Wysocka M., Trinchieri G., Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 1995, 154:5320-5330.
19. Yun C.H., Lundgren A., Azem J., Sjoling A., Holmgren J., Svennerholm A.M., Lundin B.S. Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production. Infect. Immun. 2005, 73:1482-1490.
20. Ernst P.B., Gold B.D. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol. 2000, 54:615-640.
21. Ishigami S., Natsugoe S., Tokuda K., Nakajo A., Che X., Iwashige H., Aridome K., Hokita S., Aikou T. Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer 2000, 88:577-583.
22. Takeuchi H., Maehara Y., Tokunaga E., Koga T., Kakeji Y., Sugimachi K. Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis. Am. J. Gastroenterol. 2001, 96:574-578.
23. Aparicio-Pages M.N., Verspaget H.W., Pena A.S., Lamers C.B. Natural killer cell activity in patients with adenocarcinoma in the upper gastrointestinal tract. J. Clin. Lab. Immunol. 1991, 35:27-32.
24. Kono K., Takahashi A., Ichihara F., Sugai H., Fujii H., Matsumoto Y. Impaired antibody-dependent cellular cytotoxicity mediated by herceptin in patients with gastric cancer. Cancer Res. 2002, 62:5813-5817.
25. Yoon S.J., Heo D.S., Kang S.H., Lee K.H., Kim W.S., Kim G.P., Lee J.A., Lee K.S., Bang Y.J., Kim N.K. Natural killer cell activity depression in peripheral blood and ascites from gastric cancer patients with high TGF-β 1 expression. Anticancer Res. 1998, 18:1591-1596.
26. Lundgren A., Suri-Payer E., Enarsson K., Svennerholm A.M., Lundin B.S. Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect. Immun. 2003, 71:1755-1762.
27. Raghavan S., Hjulstrom M., Holmgren J., Svennerholm A.M. Protection against experimental Helicobacter pylori infection after immunization with inactivated H. pylori whole-cell vaccines. Infect. Immun. 2002, 70:6383-6388.
28. Lundgren A., Trollmo C., Edebo A., Svennerholm A.M., Lundin B.S. Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa. Infect. Immun. 2005, 73:5612-5619.
29. Lundin B.S., Johansson C., Svennerholm A.M. Oral immunization with a Salmonella enterica serovar typhi vaccine induces specific circulating mucosa-homing CD4(+) and CD8(+) T cells in humans. Infect. Immun. 2002, 70:5622-5627.
30. Bellone G., Aste-Amezaga M., Trinchieri G., Rodeck U. Regulation of NK cell functions by TGF-beta 1. J. Immunol. 1995, 155:1066-1073.
31. Meadows S.K., Eriksson M., Barber A., Sentman C.L. Human NK cell IFN-gamma production is regulated by endogenous TGF-beta. Int. Immunopharmacol. 2006, 6:1020-1028.
32. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. J. Immunol. 2008, 180:5771-5777.
33. Baecher-Allan C., Viglietta V., Hafler D.A. Human CD4+CD25+ regulatory T cells. Semin. Immunol. 2004, 16:89-98.
34. Lindgren A., Pavlovic V., Flach C.F., Sjoling A., Lundin S. Interferon-gamma secretion is induced in IL-12 stimulated human NK cells by recognition of Helicobacter pylori or TLR2 ligands. Innate Immun. 2010, doi:10.1177/1753425909357970.
35. Watford W.T., Hissong B.D., Bream J.H., Kanno Y., Muul L., O'Shea J.J. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev. 2004, 202:139-156.
36. Cooper M.A., Fehniger T.A., Turner S.C., Chen K.S., Ghaheri B.A., Ghayur T., Carson W.E., Caligiuri M.A. Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood 2001, 97:3146-3151.
37. Wendel M., Galani I.E., Suri-Payer E., Cerwenka A. Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands. Cancer Res. 2008, 68:8437-8445.
38. Kaplan D.H., Shankaran V., Dighe A.S., Stockert E., Aguet M., Old L.J., Schreiber R.D. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc. Natl Acad. Sci. USA 1998, 95:7556-7561.
39. Shankaran V., Ikeda H., Bruce A.T., White J.M., Swanson P.E., Old L.J., Schreiber R.D. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001, 410:1107-1111.
40. Tau G.Z., Cowan S.N., Weisburg J., Braunstein N.S., Rothman P.B. Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells. J. Immunol. 2001, 167:5574-5582.
41. Liu C., Yu S., Zinn K., Wang J., Zhang L., Jia Y., Kappes J.C., Barnes S., Kimberly R.P., Grizzle W.E., Zhang H.G. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J. Immunol. 2006, 176:1375-1385.
42. Li X., Yue Z.C., Zhang Y.Y., Bai J., Meng X.N., Geng J.S., Fu S.B. Elevated serum level and gene polymorphisms of TGF-beta1 in gastric cancer. J. Clin. Lab. Anal. 2008, 22:164-171.
43. Richards J.O., Chang X., Blaser B.W., Caligiuri M.A., Zheng P., Liu Y. Tumor growth impedes natural-killer-cell maturation in the bone marrow. Blood 2006, 108:246-252.
44. Szkaradkiewicz A., Karpinski T.M., Drews M., Borejsza-Wysocki M., Majewski P., Andrzejewska E. Natural killer cell cytotoxicity and immunosuppressive cytokines (IL-10, TGF-beta1) in patients with gastric cancer. J. Biomed. Biotechnol. 2010, 2010:901564.
45. Agnello D., Lankford C.S., Bream J., Morinobu A., Gadina M., O'Shea J.J., Frucht D.M. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J. Clin. Immunol. 2003, 23:147-161.
46. Gulbinas A., Berberat P.O., Dambrauskas Z., Giese T., Giese N., Autschbach F., Kleeff J., Meuer S., Buchler M.W., Friess H. Aberrant gata-3 expression in human pancreatic cancer. J. Histochem. Cytochem. 2006, 54:161-169.
47. Gorelik L., Fields P.E., Flavell R.A. Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression. J. Immunol. 2000, 165:4773-4777.
48. Way S.S., Wilson C.B. Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet. J. Immunol. 2004, 173:5918-5922.